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Brachial-ankle pulse wave velocity: an index of central arterial stiffness?
J Hum Hypertens. 2005 May; 19(5):401-6.JH

Abstract

Brachial-ankle pulse wave velocity (baPWV) is a promising technique to assess arterial stiffness conveniently. However, it is not known whether baPWV is associated with well-established indices of central arterial stiffness. We determined the relation of baPWV with aortic (carotid-femoral) PWV, leg (femoral-ankle) PWV, and carotid augmentation index (AI) by using both cross-sectional and interventional approaches. First, we studied 409 healthy adults aged 18-76 years. baPWV correlated significantly with aortic PWV (r = 0.76), leg PWV (r = 0.76), and carotid AI (r = 0.52). A stepwise regression analysis revealed that aortic PWV was the primary independent correlate of baPWV, explaining 58% of the total variance in baPWV. Additional 23% of the variance was explained by leg PWV. Second, 13 sedentary healthy men were studied before and after a 16-week moderate aerobic exercise intervention (brisk walking to jogging; 30-45 min/day; 4-5 days/week). Reductions in aortic PWV observed with the exercise intervention were significantly and positively associated with the corresponding changes in baPWV (r = 0.74). A stepwise regression analysis revealed that changes in aortic PWV were the only independent correlate of changes in baPWV (beta = 0.74), explaining 55% of the total variance. These results suggest that baPWV may provide qualitatively similar information to those derived from central arterial stiffness although some portions of baPWV may be determined by peripheral arterial stiffness.

Authors+Show Affiliations

Sugawara J
Institute for Human Science and Bioengineering, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan. jun.sugawara@aist.go.jp
Hayashi K
No affiliation info available
Yokoi T
No affiliation info available
Cortez-Cooper MY
No affiliation info available
DeVan AE
No affiliation info available
Anton MA
No affiliation info available
Tanaka H
No affiliation info available

MeSH

AdolescentAdultAgedAnkleArteriosclerosisBlood Flow VelocityBlood PressureBlood Pressure DeterminationBrachial ArteryCarotid Artery, CommonComplianceCross-Sectional StudiesExerciseFemaleFemoral ArteryHumansJapanMaleMiddle AgedPlethysmographyPredictive Value of TestsPulseReference ValuesRestRisk FactorsSupine PositionTibial ArteriesUnited States

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15729378

Citation

Sugawara, J, et al. "Brachial-ankle Pulse Wave Velocity: an Index of Central Arterial Stiffness?" Journal of Human Hypertension, vol. 19, no. 5, 2005, pp. 401-6.
Sugawara J, Hayashi K, Yokoi T, et al. Brachial-ankle pulse wave velocity: an index of central arterial stiffness? J Hum Hypertens. 2005;19(5):401-6.
Sugawara, J., Hayashi, K., Yokoi, T., Cortez-Cooper, M. Y., DeVan, A. E., Anton, M. A., & Tanaka, H. (2005). Brachial-ankle pulse wave velocity: an index of central arterial stiffness? Journal of Human Hypertension, 19(5), 401-6.
Sugawara J, et al. Brachial-ankle Pulse Wave Velocity: an Index of Central Arterial Stiffness. J Hum Hypertens. 2005;19(5):401-6. PubMed PMID: 15729378.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brachial-ankle pulse wave velocity: an index of central arterial stiffness? AU - Sugawara,J, AU - Hayashi,K, AU - Yokoi,T, AU - Cortez-Cooper,M Y, AU - DeVan,A E, AU - Anton,M A, AU - Tanaka,H, PY - 2005/2/25/pubmed PY - 2005/8/19/medline PY - 2005/2/25/entrez SP - 401 EP - 6 JF - Journal of human hypertension JO - J Hum Hypertens VL - 19 IS - 5 N2 - Brachial-ankle pulse wave velocity (baPWV) is a promising technique to assess arterial stiffness conveniently. However, it is not known whether baPWV is associated with well-established indices of central arterial stiffness. We determined the relation of baPWV with aortic (carotid-femoral) PWV, leg (femoral-ankle) PWV, and carotid augmentation index (AI) by using both cross-sectional and interventional approaches. First, we studied 409 healthy adults aged 18-76 years. baPWV correlated significantly with aortic PWV (r = 0.76), leg PWV (r = 0.76), and carotid AI (r = 0.52). A stepwise regression analysis revealed that aortic PWV was the primary independent correlate of baPWV, explaining 58% of the total variance in baPWV. Additional 23% of the variance was explained by leg PWV. Second, 13 sedentary healthy men were studied before and after a 16-week moderate aerobic exercise intervention (brisk walking to jogging; 30-45 min/day; 4-5 days/week). Reductions in aortic PWV observed with the exercise intervention were significantly and positively associated with the corresponding changes in baPWV (r = 0.74). A stepwise regression analysis revealed that changes in aortic PWV were the only independent correlate of changes in baPWV (beta = 0.74), explaining 55% of the total variance. These results suggest that baPWV may provide qualitatively similar information to those derived from central arterial stiffness although some portions of baPWV may be determined by peripheral arterial stiffness. SN - 0950-9240 UR - https://www.unboundmedicine.com/medline/citation/15729378/Brachial_ankle_pulse_wave_velocity:_an_index_of_central_arterial_stiffness DB - PRIME DP - Unbound Medicine ER -