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REM sleep behaviour disorder in Parkinson's disease: a questionnaire-based study.
Neurol Sci. 2005 Feb; 25(6):316-21.NS

Abstract

The aim of the study was to determine the clinical frequency and features of REM sleep behaviour disorder (RBD) in a large population of Parkinson's disease (PD) patients using defined diagnostic criteria both for RBD and PD. Six trained neurologists used a semistructured questionnaire based on ICSD-R diagnostic criteria for RBD to evaluate 200 PD patients and their caregivers. Interobserver reliability for the diagnosis of RBD was "substantial" (Kappa 0.65). Five patients were excluded from the study because of an MMSE lower than 25. The demographic and PD clinical features were compared in the clinically defined RBD group and in those without RBD (NRBD). Then the RBD features during the last year were analysed in the affected group. Out of 195 patients, 66 fulfilled the ICSD-R criteria for RBD; 62 patients reported RBD during the last year (frequency 31.8%). RBD features: two or more episodes per week in 35.5%; upper limb movements in 87%; lower limb movements in 79%; vocalisations during events in 85%. RBD onset was before PD in 27% of patients; 69% of the RBD group had injured themselves or their caregivers during sleep. According to multivariate analysis, RBD was associated with male gender, age and PD duration. Brief training and the use of a semistructured questionnaire may help the neurologist in dealing with sleep disturbances in PD patients. The search for RBD symptoms in PD is highly recommended, especially in patients with a long disease duration, the risk of sleep-related injuries being high.

Authors+Show Affiliations

Department of Neurological Sciences, University of Bologna, Ugo Foscolo 7, I-40123, Bologna, Italy. cesascaglione@yahoo.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15729494

Citation

Scaglione, C, et al. "REM Sleep Behaviour Disorder in Parkinson's Disease: a Questionnaire-based Study." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 25, no. 6, 2005, pp. 316-21.
Scaglione C, Vignatelli L, Plazzi G, et al. REM sleep behaviour disorder in Parkinson's disease: a questionnaire-based study. Neurol Sci. 2005;25(6):316-21.
Scaglione, C., Vignatelli, L., Plazzi, G., Marchese, R., Negrotti, A., Rizzo, G., Lopane, G., Bassein, L., Maestri, M., Bernardini, S., Martinelli, P., Abbruzzese, G., Calzetti, S., Bonuccelli, U., Provini, F., & Coccagna, G. (2005). REM sleep behaviour disorder in Parkinson's disease: a questionnaire-based study. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 25(6), 316-21.
Scaglione C, et al. REM Sleep Behaviour Disorder in Parkinson's Disease: a Questionnaire-based Study. Neurol Sci. 2005;25(6):316-21. PubMed PMID: 15729494.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - REM sleep behaviour disorder in Parkinson's disease: a questionnaire-based study. AU - Scaglione,C, AU - Vignatelli,L, AU - Plazzi,G, AU - Marchese,R, AU - Negrotti,A, AU - Rizzo,G, AU - Lopane,G, AU - Bassein,L, AU - Maestri,M, AU - Bernardini,S, AU - Martinelli,P, AU - Abbruzzese,G, AU - Calzetti,S, AU - Bonuccelli,U, AU - Provini,F, AU - Coccagna,G, AU - ,, PY - 2004/05/28/received PY - 2004/10/20/accepted PY - 2005/2/25/pubmed PY - 2005/3/30/medline PY - 2005/2/25/entrez SP - 316 EP - 21 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol Sci VL - 25 IS - 6 N2 - The aim of the study was to determine the clinical frequency and features of REM sleep behaviour disorder (RBD) in a large population of Parkinson's disease (PD) patients using defined diagnostic criteria both for RBD and PD. Six trained neurologists used a semistructured questionnaire based on ICSD-R diagnostic criteria for RBD to evaluate 200 PD patients and their caregivers. Interobserver reliability for the diagnosis of RBD was "substantial" (Kappa 0.65). Five patients were excluded from the study because of an MMSE lower than 25. The demographic and PD clinical features were compared in the clinically defined RBD group and in those without RBD (NRBD). Then the RBD features during the last year were analysed in the affected group. Out of 195 patients, 66 fulfilled the ICSD-R criteria for RBD; 62 patients reported RBD during the last year (frequency 31.8%). RBD features: two or more episodes per week in 35.5%; upper limb movements in 87%; lower limb movements in 79%; vocalisations during events in 85%. RBD onset was before PD in 27% of patients; 69% of the RBD group had injured themselves or their caregivers during sleep. According to multivariate analysis, RBD was associated with male gender, age and PD duration. Brief training and the use of a semistructured questionnaire may help the neurologist in dealing with sleep disturbances in PD patients. The search for RBD symptoms in PD is highly recommended, especially in patients with a long disease duration, the risk of sleep-related injuries being high. SN - 1590-1874 UR - https://www.unboundmedicine.com/medline/citation/15729494/REM_sleep_behaviour_disorder_in_Parkinson's_disease:_a_questionnaire_based_study_ L2 - https://link.springer.com/10.1007/s10072-004-0364-7 DB - PRIME DP - Unbound Medicine ER -