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Isoliquiritigenin inhibits cell proliferation and induces apoptosis in human hepatoma cells.
Planta Med. 2005 Feb; 71(2):130-4.PM

Abstract

Isoliquiritigenin (4,2',4'-trihydroxychalcone, ISL) is a natural pigment with a simple chalcone structure. In this study, we report the ISL-induced inhibition on the growth of human hepatoma cells (Hep G2) for the first time. The cell growth inhibition achieved by ISL treatment resulted in programmed cell death in a caspase activation-dependent manner, with an IC50 of 10.51 microg/mL. Outcomes of ISL treatment included the up-regulation of IkappaBalpha expression in the cytoplasm, and the decrease of NF-kappaB level as well as its activity in the nucleus. In addition, ISL also suppressed the expression of Bcl-XL and c-IAP1/2 protein, the downstream target molecule of NF-kappaB. These results demonstrated that ISL treatment inhibited the NF-kappaB cell survival-signaling pathway and induced apoptotic cell death in Hep G2 cells.

Authors+Show Affiliations

Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15729620

Citation

Hsu, Ya-Ling, et al. "Isoliquiritigenin Inhibits Cell Proliferation and Induces Apoptosis in Human Hepatoma Cells." Planta Medica, vol. 71, no. 2, 2005, pp. 130-4.
Hsu YL, Kuo PL, Lin LT, et al. Isoliquiritigenin inhibits cell proliferation and induces apoptosis in human hepatoma cells. Planta Med. 2005;71(2):130-4.
Hsu, Y. L., Kuo, P. L., Lin, L. T., & Lin, C. C. (2005). Isoliquiritigenin inhibits cell proliferation and induces apoptosis in human hepatoma cells. Planta Medica, 71(2), 130-4.
Hsu YL, et al. Isoliquiritigenin Inhibits Cell Proliferation and Induces Apoptosis in Human Hepatoma Cells. Planta Med. 2005;71(2):130-4. PubMed PMID: 15729620.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isoliquiritigenin inhibits cell proliferation and induces apoptosis in human hepatoma cells. AU - Hsu,Ya-Ling, AU - Kuo,Po-Lin, AU - Lin,Liang-Tzung, AU - Lin,Chun-Ching, PY - 2005/2/25/pubmed PY - 2005/4/22/medline PY - 2005/2/25/entrez SP - 130 EP - 4 JF - Planta medica JO - Planta Med VL - 71 IS - 2 N2 - Isoliquiritigenin (4,2',4'-trihydroxychalcone, ISL) is a natural pigment with a simple chalcone structure. In this study, we report the ISL-induced inhibition on the growth of human hepatoma cells (Hep G2) for the first time. The cell growth inhibition achieved by ISL treatment resulted in programmed cell death in a caspase activation-dependent manner, with an IC50 of 10.51 microg/mL. Outcomes of ISL treatment included the up-regulation of IkappaBalpha expression in the cytoplasm, and the decrease of NF-kappaB level as well as its activity in the nucleus. In addition, ISL also suppressed the expression of Bcl-XL and c-IAP1/2 protein, the downstream target molecule of NF-kappaB. These results demonstrated that ISL treatment inhibited the NF-kappaB cell survival-signaling pathway and induced apoptotic cell death in Hep G2 cells. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/15729620/Isoliquiritigenin_inhibits_cell_proliferation_and_induces_apoptosis_in_human_hepatoma_cells_ DB - PRIME DP - Unbound Medicine ER -