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[Nonalcoholic steatohepatitis: diagnosis, pathogenesis, treatment and prognosis].
Ned Tijdschr Geneeskd. 2005 Feb 05; 149(6):289-94.NT

Abstract

Nonalcoholic steatohepatitis and chronic viral hepatitis C are the two dominant liver diseases in the Netherlands. Hepatic steatosis is usually innocuous but in twenty percent of patients it develops into steatohepatitis. One-fifth of these patients develop liver cirrhosis and hepatocellular carcinoma can also be a consequence of the disease. Nonalcoholic steatohepatitis is characterized by macrovesicular steatosis, necroinflammation, loss ofhepatocytes and fibrosis. Nonalcoholic steatohepatitis often is associated with type 2 diabetes mellitus, hypertension, dyslipoproteinemia and obesity. Insulin resistance plays a major role in the pathogenesis of this disease. Drugs against insulin resistance can ameliorate nonalcoholic steatohepatitis. Gradual weight loss, a diet including polyunsaturated fatty acids and exercise are other important treatment components of this condition.

Authors+Show Affiliations

Academisch Medisch Centrum/Universiteit van Amsterdam, afd. Maag-, Darm- en Leverziekten, Levercentrum, Meibergdreefg, 1105 AZ Amsterdam. p.l.jansen@amc.uva.nl

Pub Type(s)

English Abstract
Journal Article
Review

Language

dut

PubMed ID

15730035

Citation

Jansen, P L M.. "[Nonalcoholic Steatohepatitis: Diagnosis, Pathogenesis, Treatment and Prognosis]." Nederlands Tijdschrift Voor Geneeskunde, vol. 149, no. 6, 2005, pp. 289-94.
Jansen PL. [Nonalcoholic steatohepatitis: diagnosis, pathogenesis, treatment and prognosis]. Ned Tijdschr Geneeskd. 2005;149(6):289-94.
Jansen, P. L. (2005). [Nonalcoholic steatohepatitis: diagnosis, pathogenesis, treatment and prognosis]. Nederlands Tijdschrift Voor Geneeskunde, 149(6), 289-94.
Jansen PL. [Nonalcoholic Steatohepatitis: Diagnosis, Pathogenesis, Treatment and Prognosis]. Ned Tijdschr Geneeskd. 2005 Feb 5;149(6):289-94. PubMed PMID: 15730035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Nonalcoholic steatohepatitis: diagnosis, pathogenesis, treatment and prognosis]. A1 - Jansen,P L M, PY - 2005/2/26/pubmed PY - 2005/3/25/medline PY - 2005/2/26/entrez SP - 289 EP - 94 JF - Nederlands tijdschrift voor geneeskunde JO - Ned Tijdschr Geneeskd VL - 149 IS - 6 N2 - Nonalcoholic steatohepatitis and chronic viral hepatitis C are the two dominant liver diseases in the Netherlands. Hepatic steatosis is usually innocuous but in twenty percent of patients it develops into steatohepatitis. One-fifth of these patients develop liver cirrhosis and hepatocellular carcinoma can also be a consequence of the disease. Nonalcoholic steatohepatitis is characterized by macrovesicular steatosis, necroinflammation, loss ofhepatocytes and fibrosis. Nonalcoholic steatohepatitis often is associated with type 2 diabetes mellitus, hypertension, dyslipoproteinemia and obesity. Insulin resistance plays a major role in the pathogenesis of this disease. Drugs against insulin resistance can ameliorate nonalcoholic steatohepatitis. Gradual weight loss, a diet including polyunsaturated fatty acids and exercise are other important treatment components of this condition. SN - 0028-2162 UR - https://www.unboundmedicine.com/medline/citation/15730035/[Nonalcoholic_steatohepatitis:_diagnosis_pathogenesis_treatment_and_prognosis]_ L2 - https://medlineplus.gov/livercancer.html DB - PRIME DP - Unbound Medicine ER -