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Cytotoxic flavonol glycosides from Triplaris cumingiana.
J Nat Prod. 2005 Feb; 68(2):231-3.JN

Abstract

Three new compounds, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl-4,6-bis-O-beta-D-(3,4,5-trihydroxybenzoyl)glucopyranoside (1), 5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl-5-O-alpha-L-(3,4,5-trihydroxybenzoyl)arabinofuranoside (2), and 2-hydroxy-4-O-alpha-L-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenylarabinofuranoside (3), were isolated from the young leaves of Triplaris cumingiana, together with two known compounds, quercetin 3-O-alpha-L-(5"-O-galloyl)arabinofuranoside (4) and quercetin 3-O-beta-D-(6"-O-galloyl)glucopyranoside (5). The structures of 1-3 were established by spectroscopic methods. Compounds 1-5 were evaluated for their cytotoxic activities against the MCF-7, H-460, and SF-268 human cancer cell lines.

Authors+Show Affiliations

Centro de Investigaciones Farmacognósticas de la Flora Panameña (CIFLORPAN), Facultad de Farmacia, Universidad de Panamá, Apartado 10767, Estafeta Universitaria, Panamá, República de Panamá.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15730249

Citation

Hussein, Ahmed A., et al. "Cytotoxic Flavonol Glycosides From Triplaris Cumingiana." Journal of Natural Products, vol. 68, no. 2, 2005, pp. 231-3.
Hussein AA, Barberena I, Correa M, et al. Cytotoxic flavonol glycosides from Triplaris cumingiana. J Nat Prod. 2005;68(2):231-3.
Hussein, A. A., Barberena, I., Correa, M., Coley, P. D., Solis, P. N., & Gupta, M. P. (2005). Cytotoxic flavonol glycosides from Triplaris cumingiana. Journal of Natural Products, 68(2), 231-3.
Hussein AA, et al. Cytotoxic Flavonol Glycosides From Triplaris Cumingiana. J Nat Prod. 2005;68(2):231-3. PubMed PMID: 15730249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxic flavonol glycosides from Triplaris cumingiana. AU - Hussein,Ahmed A, AU - Barberena,Icela, AU - Correa,Mireya, AU - Coley,Phyllis D, AU - Solis,Pablo N, AU - Gupta,Mahabir P, PY - 2005/2/26/pubmed PY - 2005/4/14/medline PY - 2005/2/26/entrez SP - 231 EP - 3 JF - Journal of natural products JO - J Nat Prod VL - 68 IS - 2 N2 - Three new compounds, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl-4,6-bis-O-beta-D-(3,4,5-trihydroxybenzoyl)glucopyranoside (1), 5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl-5-O-alpha-L-(3,4,5-trihydroxybenzoyl)arabinofuranoside (2), and 2-hydroxy-4-O-alpha-L-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenylarabinofuranoside (3), were isolated from the young leaves of Triplaris cumingiana, together with two known compounds, quercetin 3-O-alpha-L-(5"-O-galloyl)arabinofuranoside (4) and quercetin 3-O-beta-D-(6"-O-galloyl)glucopyranoside (5). The structures of 1-3 were established by spectroscopic methods. Compounds 1-5 were evaluated for their cytotoxic activities against the MCF-7, H-460, and SF-268 human cancer cell lines. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/15730249/Cytotoxic_flavonol_glycosides_from_Triplaris_cumingiana_ L2 - https://doi.org/10.1021/np049803g DB - PRIME DP - Unbound Medicine ER -