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Triterpenoid saponins from the roots of Pulsatilla koreana.
J Nat Prod. 2005 Feb; 68(2):268-72.JN

Abstract

Six new saponins, five lupanes (1-5) and one oleanane (6), along with 11 known saponins, were isolated from the roots of Pulsatilla koreana. The structures of the new saponins were found to be 23-hydroxy-3beta-[(O-alpha-L-rhamnopyranosyl-(1-->2)-O-[O-beta-D-glucopyranosyl-(1-->4)]-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid (1), 23-hydroxy-3beta-[(O-beta-D-glucopyranosyl-(1-->3)-O-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid (2), 3beta-[(O-alpha-L-rhamnopyranosyl-(1-->2)-O-[O-beta-D-glucopyranosyl-(1-->4)]-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid (3), 3beta-[(O-beta-D-glucopyranosyl-(1-->3)-O-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid (4), 23-hydroxy-3beta-[(O-beta-D-glucopyranosyl-(1-->4)-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid (5), and hederagenin 3-O-beta-D-glucopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside (6). Their structures were determined on the basis of 1D and 2D NMR ((13)C NMR, (1)H NMR, (1)H-(1)H COSY, HMQC, and HMBC) methods, FABMS, and hydrolysis. All isolated compounds were evaluated for their cytotoxic activity against A-549 human lung carcinoma cells.

Authors+Show Affiliations

Bang SC
Central Research Institute, SB Pharmaceutical Co. (Ltd), Gongju 314-923, Chungnam, Korea.
Kim Y
No affiliation info available
Lee JH
No affiliation info available
Ahn BZ
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicDrug Screening Assays, AntitumorHumansKoreaMolecular StructurePlant RootsPlants, MedicinalSaponinsTriterpenesTumor Cells, Cultured

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15730260

Citation

Bang, Seong-Cheol, et al. "Triterpenoid Saponins From the Roots of Pulsatilla Koreana." Journal of Natural Products, vol. 68, no. 2, 2005, pp. 268-72.
Bang SC, Kim Y, Lee JH, et al. Triterpenoid saponins from the roots of Pulsatilla koreana. J Nat Prod. 2005;68(2):268-72.
Bang, S. C., Kim, Y., Lee, J. H., & Ahn, B. Z. (2005). Triterpenoid saponins from the roots of Pulsatilla koreana. Journal of Natural Products, 68(2), 268-72.
Bang SC, et al. Triterpenoid Saponins From the Roots of Pulsatilla Koreana. J Nat Prod. 2005;68(2):268-72. PubMed PMID: 15730260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Triterpenoid saponins from the roots of Pulsatilla koreana. AU - Bang,Seong-Cheol, AU - Kim,Yong, AU - Lee,Jee-Hyun, AU - Ahn,Byung-Zun, PY - 2005/2/26/pubmed PY - 2005/4/14/medline PY - 2005/2/26/entrez SP - 268 EP - 72 JF - Journal of natural products JO - J Nat Prod VL - 68 IS - 2 N2 - Six new saponins, five lupanes (1-5) and one oleanane (6), along with 11 known saponins, were isolated from the roots of Pulsatilla koreana. The structures of the new saponins were found to be 23-hydroxy-3beta-[(O-alpha-L-rhamnopyranosyl-(1-->2)-O-[O-beta-D-glucopyranosyl-(1-->4)]-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid (1), 23-hydroxy-3beta-[(O-beta-D-glucopyranosyl-(1-->3)-O-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid (2), 3beta-[(O-alpha-L-rhamnopyranosyl-(1-->2)-O-[O-beta-D-glucopyranosyl-(1-->4)]-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid (3), 3beta-[(O-beta-D-glucopyranosyl-(1-->3)-O-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid (4), 23-hydroxy-3beta-[(O-beta-D-glucopyranosyl-(1-->4)-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid (5), and hederagenin 3-O-beta-D-glucopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside (6). Their structures were determined on the basis of 1D and 2D NMR ((13)C NMR, (1)H NMR, (1)H-(1)H COSY, HMQC, and HMBC) methods, FABMS, and hydrolysis. All isolated compounds were evaluated for their cytotoxic activity against A-549 human lung carcinoma cells. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/15730260/Triterpenoid_saponins_from_the_roots_of_Pulsatilla_koreana_ DB - PRIME DP - Unbound Medicine ER -