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Triterpenoid saponins from the roots of Pulsatilla koreana.
J Nat Prod. 2005 Feb; 68(2):268-72.JN

Abstract

Six new saponins, five lupanes (1-5) and one oleanane (6), along with 11 known saponins, were isolated from the roots of Pulsatilla koreana. The structures of the new saponins were found to be 23-hydroxy-3beta-[(O-alpha-L-rhamnopyranosyl-(1-->2)-O-[O-beta-D-glucopyranosyl-(1-->4)]-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid (1), 23-hydroxy-3beta-[(O-beta-D-glucopyranosyl-(1-->3)-O-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid (2), 3beta-[(O-alpha-L-rhamnopyranosyl-(1-->2)-O-[O-beta-D-glucopyranosyl-(1-->4)]-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid (3), 3beta-[(O-beta-D-glucopyranosyl-(1-->3)-O-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid (4), 23-hydroxy-3beta-[(O-beta-D-glucopyranosyl-(1-->4)-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid (5), and hederagenin 3-O-beta-D-glucopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside (6). Their structures were determined on the basis of 1D and 2D NMR ((13)C NMR, (1)H NMR, (1)H-(1)H COSY, HMQC, and HMBC) methods, FABMS, and hydrolysis. All isolated compounds were evaluated for their cytotoxic activity against A-549 human lung carcinoma cells.

Authors+Show Affiliations

Central Research Institute, SB Pharmaceutical Co. (Ltd), Gongju 314-923, Chungnam, Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15730260

Citation

Bang, Seong-Cheol, et al. "Triterpenoid Saponins From the Roots of Pulsatilla Koreana." Journal of Natural Products, vol. 68, no. 2, 2005, pp. 268-72.
Bang SC, Kim Y, Lee JH, et al. Triterpenoid saponins from the roots of Pulsatilla koreana. J Nat Prod. 2005;68(2):268-72.
Bang, S. C., Kim, Y., Lee, J. H., & Ahn, B. Z. (2005). Triterpenoid saponins from the roots of Pulsatilla koreana. Journal of Natural Products, 68(2), 268-72.
Bang SC, et al. Triterpenoid Saponins From the Roots of Pulsatilla Koreana. J Nat Prod. 2005;68(2):268-72. PubMed PMID: 15730260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Triterpenoid saponins from the roots of Pulsatilla koreana. AU - Bang,Seong-Cheol, AU - Kim,Yong, AU - Lee,Jee-Hyun, AU - Ahn,Byung-Zun, PY - 2005/2/26/pubmed PY - 2005/4/14/medline PY - 2005/2/26/entrez SP - 268 EP - 72 JF - Journal of natural products JO - J Nat Prod VL - 68 IS - 2 N2 - Six new saponins, five lupanes (1-5) and one oleanane (6), along with 11 known saponins, were isolated from the roots of Pulsatilla koreana. The structures of the new saponins were found to be 23-hydroxy-3beta-[(O-alpha-L-rhamnopyranosyl-(1-->2)-O-[O-beta-D-glucopyranosyl-(1-->4)]-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid (1), 23-hydroxy-3beta-[(O-beta-D-glucopyranosyl-(1-->3)-O-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid (2), 3beta-[(O-alpha-L-rhamnopyranosyl-(1-->2)-O-[O-beta-D-glucopyranosyl-(1-->4)]-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid (3), 3beta-[(O-beta-D-glucopyranosyl-(1-->3)-O-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid (4), 23-hydroxy-3beta-[(O-beta-D-glucopyranosyl-(1-->4)-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid (5), and hederagenin 3-O-beta-D-glucopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside (6). Their structures were determined on the basis of 1D and 2D NMR ((13)C NMR, (1)H NMR, (1)H-(1)H COSY, HMQC, and HMBC) methods, FABMS, and hydrolysis. All isolated compounds were evaluated for their cytotoxic activity against A-549 human lung carcinoma cells. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/15730260/Triterpenoid_saponins_from_the_roots_of_Pulsatilla_koreana_ L2 - https://doi.org/10.1021/np049813h DB - PRIME DP - Unbound Medicine ER -