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Effects of post-treatment with low-dose propofol on inflammatory responses to lipopolysaccharide-induced shock in conscious rats.
Clin Exp Pharmacol Physiol. 2005 Jan-Feb; 32(1-2):24-9.CE

Abstract

1. In the present study, we used a low dose of propofol (5 mg/kg per h) to investigate its effects on the pro-inflammatory cytokines (tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-10) and changes in nitric oxide (NO) following lipopolysaccharide (LPS) for a period of 12 h in conscious rats. 2. Experiments were designed to induce endotoxin shock by intravenous injection of Klebsiella pneumoniae LPS (10 mg/kg) in conscious rats. Arterial pressure (AP) and heart rate (HR) were monitored continuously for 12 h after LPS administration. Tumour necrosis factor-alpha, IL-1beta, IL-10 and plasma nitrates/nitrites were determined before and 0.5, 1, 3, 6, 9 and 12 h after LPS administration. A low dose of intravenous propofol (5 mg/kg per h) was administered to investigate the effects on cytokine responses and changes in NO in endotoxin shock. 3. Lipopolysaccharide significantly increased TNF-alpha, IL-1beta, IL-10, nitrites/nitrates and HR, whereas mean AP was decreased. Post-treatment with propofol suppressed the release of TNF-alpha, IL-1beta, IL-10 and NO production after endotoxin shock. 4. Lipopolysaccharide also caused a decrease in the white blood cell count and haematocrit. 5. Post-treatment with propofol slightly, but not significantly, affected the LPS-induced systemic hypotension, tachycardia, leukocytopenia and anaemia. 6. These findings suggest that low-dose propofol may be beneficial to the inflammatory change in sepsis.

Authors+Show Affiliations

Department of Nephrology, Tzu Chi General Hospital, Hualien, Taiwan, Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15730430

Citation

Hsu, Bang Gee, et al. "Effects of Post-treatment With Low-dose Propofol On Inflammatory Responses to Lipopolysaccharide-induced Shock in Conscious Rats." Clinical and Experimental Pharmacology & Physiology, vol. 32, no. 1-2, 2005, pp. 24-9.
Hsu BG, Yang FL, Lee RP, et al. Effects of post-treatment with low-dose propofol on inflammatory responses to lipopolysaccharide-induced shock in conscious rats. Clin Exp Pharmacol Physiol. 2005;32(1-2):24-9.
Hsu, B. G., Yang, F. L., Lee, R. P., Peng, T. C., & Chen, H. I. (2005). Effects of post-treatment with low-dose propofol on inflammatory responses to lipopolysaccharide-induced shock in conscious rats. Clinical and Experimental Pharmacology & Physiology, 32(1-2), 24-9.
Hsu BG, et al. Effects of Post-treatment With Low-dose Propofol On Inflammatory Responses to Lipopolysaccharide-induced Shock in Conscious Rats. Clin Exp Pharmacol Physiol. 2005 Jan-Feb;32(1-2):24-9. PubMed PMID: 15730430.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of post-treatment with low-dose propofol on inflammatory responses to lipopolysaccharide-induced shock in conscious rats. AU - Hsu,Bang Gee, AU - Yang,Fwu Lin, AU - Lee,Ru Ping, AU - Peng,Tai Chu, AU - Chen,Hsing I, PY - 2005/2/26/pubmed PY - 2005/6/9/medline PY - 2005/2/26/entrez SP - 24 EP - 9 JF - Clinical and experimental pharmacology & physiology JO - Clin Exp Pharmacol Physiol VL - 32 IS - 1-2 N2 - 1. In the present study, we used a low dose of propofol (5 mg/kg per h) to investigate its effects on the pro-inflammatory cytokines (tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-10) and changes in nitric oxide (NO) following lipopolysaccharide (LPS) for a period of 12 h in conscious rats. 2. Experiments were designed to induce endotoxin shock by intravenous injection of Klebsiella pneumoniae LPS (10 mg/kg) in conscious rats. Arterial pressure (AP) and heart rate (HR) were monitored continuously for 12 h after LPS administration. Tumour necrosis factor-alpha, IL-1beta, IL-10 and plasma nitrates/nitrites were determined before and 0.5, 1, 3, 6, 9 and 12 h after LPS administration. A low dose of intravenous propofol (5 mg/kg per h) was administered to investigate the effects on cytokine responses and changes in NO in endotoxin shock. 3. Lipopolysaccharide significantly increased TNF-alpha, IL-1beta, IL-10, nitrites/nitrates and HR, whereas mean AP was decreased. Post-treatment with propofol suppressed the release of TNF-alpha, IL-1beta, IL-10 and NO production after endotoxin shock. 4. Lipopolysaccharide also caused a decrease in the white blood cell count and haematocrit. 5. Post-treatment with propofol slightly, but not significantly, affected the LPS-induced systemic hypotension, tachycardia, leukocytopenia and anaemia. 6. These findings suggest that low-dose propofol may be beneficial to the inflammatory change in sepsis. SN - 0305-1870 UR - https://www.unboundmedicine.com/medline/citation/15730430/Effects_of_post_treatment_with_low_dose_propofol_on_inflammatory_responses_to_lipopolysaccharide_induced_shock_in_conscious_rats_ L2 - https://doi.org/10.1111/j.1440-1681.2005.04155.x DB - PRIME DP - Unbound Medicine ER -