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[Effect of ligustrazine on airway remodeling in asthmatic rats].
Zhonghua Jie He He Hu Xi Za Zhi. 2004 Dec; 27(12):833-6.ZJ

Abstract

OBJECTIVE

To observe the effect and mechanism of ligustrazine on the airway remodeling.

METHODS

Thirty-two SD rats were randomly divided into 4 groups: the normal group (A), the model group (B), the ligustrazine low-dose group (C, 40 mg/kg) and the ligustrazine high-dose group (D, 80 mg/kg), with 8 rats in each group. The chronic asthmatic model was established by repeated inhalation of ovalbumin. The changes of collagen and transforming growth factor-beta(1) (TGF-beta(1)) contents in the airway wall, the thickness of smooth muscle and basement membrane, inner and outer diameter were measured by the computerized image analysis system.

RESULTS

The thickness of smooth muscle and basement membrane were (11.3 +/- 1.3, 11.3 +/- 1.7) microm in D group, (19.7 +/- 1.8, 19.8 +/- 1.6) microm in B group, the difference being significant (P < 0.01), as compared with A group [(10.6 +/- 1.2) microm, (9.8 +/- 1.6) microm] and C group [(11.6 +/- 0.9) microm, (12.3 +/- 1.8) microm], the difference being not significant (all P > 0.05). The difference in the ratio of inner diameter to outer diameter was significant between D group (0.77 +/- 0.06) and B group (0.63 +/- 0.05), P < 0.01. The contents of collagen type III and TGF-beta(1) were (21 +/- 5, 26 +/- 5) in D group, (55 +/- 7, 69 +/- 14) in B group, the difference being significant (P < 0.01). The differences were also significant when C group [32 +/- 8, 38 +/- 10] was compared with D group (P < 0.05) and B group (P < 0.01). The contents of collagen type I showed no difference among the 4 groups (A group: 34 +/- 13, B group: 44 +/- 8, C group: 36 +/- 8, D group: 39 +/- 8; all P > 0.05). A close correlation between TGF-beta(1) and collagen type III was demonstrated (r = 0.844 2, P < 0.01).

CONCLUSION

Ligustrazine might suppress airway remodeling by decreasing the expression of TGF-beta(1) and reducing deposition of collagen.

Authors+Show Affiliations

Department of Pediatrics, Zhongda Hospital, Southeast University, Nanjing 210009, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

15730784

Citation

Wang, Wen-Jian, et al. "[Effect of Ligustrazine On Airway Remodeling in Asthmatic Rats]." Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 27, no. 12, 2004, pp. 833-6.
Wang WJ, Yang L, Wang XH, et al. [Effect of ligustrazine on airway remodeling in asthmatic rats]. Zhonghua Jie He He Hu Xi Za Zhi. 2004;27(12):833-6.
Wang, W. J., Yang, L., Wang, X. H., & Li, H. L. (2004). [Effect of ligustrazine on airway remodeling in asthmatic rats]. Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, 27(12), 833-6.
Wang WJ, et al. [Effect of Ligustrazine On Airway Remodeling in Asthmatic Rats]. Zhonghua Jie He He Hu Xi Za Zhi. 2004;27(12):833-6. PubMed PMID: 15730784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of ligustrazine on airway remodeling in asthmatic rats]. AU - Wang,Wen-Jian, AU - Yang,Li, AU - Wang,Xi-Hua, AU - Li,Hai-Lang, PY - 2005/2/26/pubmed PY - 2007/3/7/medline PY - 2005/2/26/entrez SP - 833 EP - 6 JF - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases JO - Zhonghua Jie He He Hu Xi Za Zhi VL - 27 IS - 12 N2 - OBJECTIVE: To observe the effect and mechanism of ligustrazine on the airway remodeling. METHODS: Thirty-two SD rats were randomly divided into 4 groups: the normal group (A), the model group (B), the ligustrazine low-dose group (C, 40 mg/kg) and the ligustrazine high-dose group (D, 80 mg/kg), with 8 rats in each group. The chronic asthmatic model was established by repeated inhalation of ovalbumin. The changes of collagen and transforming growth factor-beta(1) (TGF-beta(1)) contents in the airway wall, the thickness of smooth muscle and basement membrane, inner and outer diameter were measured by the computerized image analysis system. RESULTS: The thickness of smooth muscle and basement membrane were (11.3 +/- 1.3, 11.3 +/- 1.7) microm in D group, (19.7 +/- 1.8, 19.8 +/- 1.6) microm in B group, the difference being significant (P < 0.01), as compared with A group [(10.6 +/- 1.2) microm, (9.8 +/- 1.6) microm] and C group [(11.6 +/- 0.9) microm, (12.3 +/- 1.8) microm], the difference being not significant (all P > 0.05). The difference in the ratio of inner diameter to outer diameter was significant between D group (0.77 +/- 0.06) and B group (0.63 +/- 0.05), P < 0.01. The contents of collagen type III and TGF-beta(1) were (21 +/- 5, 26 +/- 5) in D group, (55 +/- 7, 69 +/- 14) in B group, the difference being significant (P < 0.01). The differences were also significant when C group [32 +/- 8, 38 +/- 10] was compared with D group (P < 0.05) and B group (P < 0.01). The contents of collagen type I showed no difference among the 4 groups (A group: 34 +/- 13, B group: 44 +/- 8, C group: 36 +/- 8, D group: 39 +/- 8; all P > 0.05). A close correlation between TGF-beta(1) and collagen type III was demonstrated (r = 0.844 2, P < 0.01). CONCLUSION: Ligustrazine might suppress airway remodeling by decreasing the expression of TGF-beta(1) and reducing deposition of collagen. SN - 1001-0939 UR - https://www.unboundmedicine.com/medline/citation/15730784/[Effect_of_ligustrazine_on_airway_remodeling_in_asthmatic_rats]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=1001-0939&amp;year=2004&amp;vol=27&amp;issue=12&amp;fpage=833 DB - PRIME DP - Unbound Medicine ER -