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Treatment of patients with alcoholic liver disease.

Abstract

BACKGROUND

The proportion of alcoholic liver disease among all kinds of liver diseases in China is increasing. Recent research has elucidated the mechanisms of alcohol-induced liver injury and offered the prospect of advances in the management of alcoholic liver disease.

DATA RESOURCES

Searching MEDLINE (1982-July 2004) for papers on alcoholic liver disease, especially those on the treatment of alcoholic liver disease.

RESULTS

Abstinence remains the cornerstone of management of all forms of alcoholic liver disease. Nutritional support therapy is also a basal treatment. Corticosteroids may be benefitial for some severe alcoholic hepatitis. None of other measures including anti-inflammatory agents, antioxidants or colchicine has been shown consistently to improve the course of alcoholic liver damage. Ultimately, liver transplantation remains an option for selected patients with liver failure due to chronic alcoholic liver disease.

CONCLUSIONS

Abstinence and nutritional support remain the base management of alcoholic liver disease. Corticosteroid is efficient for some severe alcoholic hepatitis. Anti-inflammatory agents and antioxidants may be of benefit but need further studies. The efficacy of other measures including the use of colchicine and propylthiouracil is controversial. Liver transplantation remains an option for selected patients with liver failure.

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  • Authors+Show Affiliations

    ,

    Liver Research Center, Beijing Friendship Hospital, Capital University of Medical Sciences, Beijing 100050, China. frankliver@yahoo.com.cn

    ,

    Source

    MeSH

    Adrenal Cortex Hormones
    Antioxidants
    Combined Modality Therapy
    Drug Therapy, Combination
    Female
    Hepatitis, Alcoholic
    Humans
    Liver Cirrhosis, Alcoholic
    Liver Diseases, Alcoholic
    Liver Function Tests
    Male
    Nutritional Support
    Pentoxifylline
    Prognosis
    Risk Assessment
    Severity of Illness Index
    Silymarin
    Survival Rate
    Treatment Outcome
    Tumor Necrosis Factor-alpha
    Vitamin E

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    15730911

    Citation

    Zhang, Fu-Kui, et al. "Treatment of Patients With Alcoholic Liver Disease." Hepatobiliary & Pancreatic Diseases International : HBPD INT, vol. 4, no. 1, 2005, pp. 12-7.
    Zhang FK, Zhang JY, Jia JD. Treatment of patients with alcoholic liver disease. HBPD INT. 2005;4(1):12-7.
    Zhang, F. K., Zhang, J. Y., & Jia, J. D. (2005). Treatment of patients with alcoholic liver disease. Hepatobiliary & Pancreatic Diseases International : HBPD INT, 4(1), pp. 12-7.
    Zhang FK, Zhang JY, Jia JD. Treatment of Patients With Alcoholic Liver Disease. HBPD INT. 2005;4(1):12-7. PubMed PMID: 15730911.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Treatment of patients with alcoholic liver disease. AU - Zhang,Fu-Kui, AU - Zhang,Jun-Yong, AU - Jia,Ji-Dong, PY - 2005/2/26/pubmed PY - 2005/4/7/medline PY - 2005/2/26/entrez SP - 12 EP - 7 JF - Hepatobiliary & pancreatic diseases international : HBPD INT JO - HBPD INT VL - 4 IS - 1 N2 - BACKGROUND: The proportion of alcoholic liver disease among all kinds of liver diseases in China is increasing. Recent research has elucidated the mechanisms of alcohol-induced liver injury and offered the prospect of advances in the management of alcoholic liver disease. DATA RESOURCES: Searching MEDLINE (1982-July 2004) for papers on alcoholic liver disease, especially those on the treatment of alcoholic liver disease. RESULTS: Abstinence remains the cornerstone of management of all forms of alcoholic liver disease. Nutritional support therapy is also a basal treatment. Corticosteroids may be benefitial for some severe alcoholic hepatitis. None of other measures including anti-inflammatory agents, antioxidants or colchicine has been shown consistently to improve the course of alcoholic liver damage. Ultimately, liver transplantation remains an option for selected patients with liver failure due to chronic alcoholic liver disease. CONCLUSIONS: Abstinence and nutritional support remain the base management of alcoholic liver disease. Corticosteroid is efficient for some severe alcoholic hepatitis. Anti-inflammatory agents and antioxidants may be of benefit but need further studies. The efficacy of other measures including the use of colchicine and propylthiouracil is controversial. Liver transplantation remains an option for selected patients with liver failure. SN - 1499-3872 UR - https://www.unboundmedicine.com/medline/citation/15730911/Treatment_of_patients_with_alcoholic_liver_disease_ L2 - http://www.hbpdint.com/EN/Y2005/V4/I1/12 DB - PRIME DP - Unbound Medicine ER -