Tags

Type your tag names separated by a space and hit enter

Photoreceptor layer features in eyes with closed macular holes: optical coherence tomography findings and correlation with visual outcomes.
Am J Ophthalmol 2005; 139(2):280-9AJ

Abstract

PURPOSE

Study correlation between optical coherence tomography (OCT) findings and visual acuity (VA) outcomes after successful macular hole surgery (MHS).

DESIGN

Retrospective cross-sectional study.

METHODS

Postoperative OCT scans were analyzed in 34 eyes of 30 patients. Raw files of horizontal and vertical OCT scans were exported to Adobe Photoshop 7.0. Measured parameters included central foveal thickness, photoreceptor thickness, photoreceptor reflectivity, and relative reflectivity of photoreceptor to retinal pigment epithelium in the foveal area. Foveal configuration was subjectively graded.

RESULTS

OCT scans were obtained at a median of 2 years (1 month to 10 years) postoperatively. The median visual acuity was 20/80 (20/50 to 8/200) preoperatively and 20/50 (20/20 to 5/200) postoperatively. The median foveal thickness was 198.5 micro (148 to 283). The mean (SD) photoreceptor layer thickness was 16.5 (8) micro in the 500 micro area and 17.5 (8) micro in the 1000 micro area. Mean (SD) of relative reflectivity of the photoreceptor layer was 0.60 (0.10) in both 500 micro and 1000 micro area. Postoperative VA did not correlate with foveal thickness or foveal configuration. Central (500 micro and 1000 micro) photoreceptor thickness was significantly correlated with final VA (r = .38, P = .026, each). Relative reflectivity of photoreceptors to retinal pigment epithelium in the 500 micro area was correlated with postoperative VA at a borderline significance (r = .32, P = .07). Relative reflectivity of photoreceptors to retinal pigment epithelium in the 1000 micro area was not significantly correlated with postoperative VA (r = .27, P = .12).

CONCLUSION

Specific retinal features can be assessed from OCT images. Morphology and thickness of the foveal photoreceptor layer correlate well with macular function after successful MHS. Outer retinal features appear to be more important to determine postoperative visual function. Inner retinal features may be more relevant for the ophthalmoscopic appearance of anatomic closure.

Authors+Show Affiliations

Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, Miami, Florida 33136, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15733989

Citation

Villate, Natalia, et al. "Photoreceptor Layer Features in Eyes With Closed Macular Holes: Optical Coherence Tomography Findings and Correlation With Visual Outcomes." American Journal of Ophthalmology, vol. 139, no. 2, 2005, pp. 280-9.
Villate N, Lee JE, Venkatraman A, et al. Photoreceptor layer features in eyes with closed macular holes: optical coherence tomography findings and correlation with visual outcomes. Am J Ophthalmol. 2005;139(2):280-9.
Villate, N., Lee, J. E., Venkatraman, A., & Smiddy, W. E. (2005). Photoreceptor layer features in eyes with closed macular holes: optical coherence tomography findings and correlation with visual outcomes. American Journal of Ophthalmology, 139(2), pp. 280-9.
Villate N, et al. Photoreceptor Layer Features in Eyes With Closed Macular Holes: Optical Coherence Tomography Findings and Correlation With Visual Outcomes. Am J Ophthalmol. 2005;139(2):280-9. PubMed PMID: 15733989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Photoreceptor layer features in eyes with closed macular holes: optical coherence tomography findings and correlation with visual outcomes. AU - Villate,Natalia, AU - Lee,Ji Eun, AU - Venkatraman,Anna, AU - Smiddy,William E, PY - 2004/09/13/accepted PY - 2005/3/1/pubmed PY - 2005/4/12/medline PY - 2005/3/1/entrez SP - 280 EP - 9 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 139 IS - 2 N2 - PURPOSE: Study correlation between optical coherence tomography (OCT) findings and visual acuity (VA) outcomes after successful macular hole surgery (MHS). DESIGN: Retrospective cross-sectional study. METHODS: Postoperative OCT scans were analyzed in 34 eyes of 30 patients. Raw files of horizontal and vertical OCT scans were exported to Adobe Photoshop 7.0. Measured parameters included central foveal thickness, photoreceptor thickness, photoreceptor reflectivity, and relative reflectivity of photoreceptor to retinal pigment epithelium in the foveal area. Foveal configuration was subjectively graded. RESULTS: OCT scans were obtained at a median of 2 years (1 month to 10 years) postoperatively. The median visual acuity was 20/80 (20/50 to 8/200) preoperatively and 20/50 (20/20 to 5/200) postoperatively. The median foveal thickness was 198.5 micro (148 to 283). The mean (SD) photoreceptor layer thickness was 16.5 (8) micro in the 500 micro area and 17.5 (8) micro in the 1000 micro area. Mean (SD) of relative reflectivity of the photoreceptor layer was 0.60 (0.10) in both 500 micro and 1000 micro area. Postoperative VA did not correlate with foveal thickness or foveal configuration. Central (500 micro and 1000 micro) photoreceptor thickness was significantly correlated with final VA (r = .38, P = .026, each). Relative reflectivity of photoreceptors to retinal pigment epithelium in the 500 micro area was correlated with postoperative VA at a borderline significance (r = .32, P = .07). Relative reflectivity of photoreceptors to retinal pigment epithelium in the 1000 micro area was not significantly correlated with postoperative VA (r = .27, P = .12). CONCLUSION: Specific retinal features can be assessed from OCT images. Morphology and thickness of the foveal photoreceptor layer correlate well with macular function after successful MHS. Outer retinal features appear to be more important to determine postoperative visual function. Inner retinal features may be more relevant for the ophthalmoscopic appearance of anatomic closure. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/15733989/Photoreceptor_layer_features_in_eyes_with_closed_macular_holes:_optical_coherence_tomography_findings_and_correlation_with_visual_outcomes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(04)01120-1 DB - PRIME DP - Unbound Medicine ER -