Tags

Type your tag names separated by a space and hit enter

Neuromotor functions in Inuit preschool children exposed to Pb, PCBs, and Hg.
Neurotoxicol Teratol. 2005 Mar-Apr; 27(2):245-57.NT

Abstract

The aim of this study was to examine the effects of prenatal and postnatal chronic exposure to mercury (Hg), polychlorinated biphenyls (PCBs) and lead (Pb) on the neuromotor development of preschool children. The study population consisted of 110 preschool Inuit children from Nunavik (Canada). Blood Hg, PCBs and Pb concentrations were measured at birth (cord blood) and at the time of testing. Gross motor functions were evaluated and a neurological examination was performed. Fine neuromotor performance was assessed using quantitative measures of postural hand tremor, reaction time, sway oscillations, as well as alternating and pointing movements. Potential covariates were documented including demographic and familial characteristics, other prenatal neurotoxicants (alcohol, tobacco) and nutrients (selenium (Se), Omega-3 polyunsaturated fatty acids (n-3 PUFA)). Hierarchical multivariate regression analyses were performed, controlling for significant covariates. Gross motor development was not linked to prenatal exposures. However, significant associations were observed between blood Pb concentration at testing time and changes in reaction time, sway oscillations, alternating arm movements and action tremor. For some of these outcomes, neuromotor effects of Pb exposure are observed at blood concentrations below 10 microg/dl. Negative effects of PCBs on neuromotor development were not clearly observed, neither were the potential beneficial effects of n-3 PUFA and selenium. Tremor amplitude was related to blood Hg concentrations at testing time, which corroborate an effect already reported among adults.

Authors+Show Affiliations

Cognitive Neuroscience Center, University of Quebec at Montreal, Montreal, Quebec, C.P. 8888 (Succ Centre Ville), Canada H3C 3P8.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15734276

Citation

Després, Christine, et al. "Neuromotor Functions in Inuit Preschool Children Exposed to Pb, PCBs, and Hg." Neurotoxicology and Teratology, vol. 27, no. 2, 2005, pp. 245-57.
Després C, Beuter A, Richer F, et al. Neuromotor functions in Inuit preschool children exposed to Pb, PCBs, and Hg. Neurotoxicol Teratol. 2005;27(2):245-57.
Després, C., Beuter, A., Richer, F., Poitras, K., Veilleux, A., Ayotte, P., Dewailly, E., Saint-Amour, D., & Muckle, G. (2005). Neuromotor functions in Inuit preschool children exposed to Pb, PCBs, and Hg. Neurotoxicology and Teratology, 27(2), 245-57.
Després C, et al. Neuromotor Functions in Inuit Preschool Children Exposed to Pb, PCBs, and Hg. Neurotoxicol Teratol. 2005 Mar-Apr;27(2):245-57. PubMed PMID: 15734276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuromotor functions in Inuit preschool children exposed to Pb, PCBs, and Hg. AU - Després,Christine, AU - Beuter,Anne, AU - Richer,François, AU - Poitras,Karine, AU - Veilleux,Annie, AU - Ayotte,Pierre, AU - Dewailly,Eric, AU - Saint-Amour,Dave, AU - Muckle,Gina, Y1 - 2005/01/11/ PY - 2003/11/07/received PY - 2004/11/04/revised PY - 2004/12/01/accepted PY - 2005/3/1/pubmed PY - 2005/5/10/medline PY - 2005/3/1/entrez SP - 245 EP - 57 JF - Neurotoxicology and teratology JO - Neurotoxicol Teratol VL - 27 IS - 2 N2 - The aim of this study was to examine the effects of prenatal and postnatal chronic exposure to mercury (Hg), polychlorinated biphenyls (PCBs) and lead (Pb) on the neuromotor development of preschool children. The study population consisted of 110 preschool Inuit children from Nunavik (Canada). Blood Hg, PCBs and Pb concentrations were measured at birth (cord blood) and at the time of testing. Gross motor functions were evaluated and a neurological examination was performed. Fine neuromotor performance was assessed using quantitative measures of postural hand tremor, reaction time, sway oscillations, as well as alternating and pointing movements. Potential covariates were documented including demographic and familial characteristics, other prenatal neurotoxicants (alcohol, tobacco) and nutrients (selenium (Se), Omega-3 polyunsaturated fatty acids (n-3 PUFA)). Hierarchical multivariate regression analyses were performed, controlling for significant covariates. Gross motor development was not linked to prenatal exposures. However, significant associations were observed between blood Pb concentration at testing time and changes in reaction time, sway oscillations, alternating arm movements and action tremor. For some of these outcomes, neuromotor effects of Pb exposure are observed at blood concentrations below 10 microg/dl. Negative effects of PCBs on neuromotor development were not clearly observed, neither were the potential beneficial effects of n-3 PUFA and selenium. Tremor amplitude was related to blood Hg concentrations at testing time, which corroborate an effect already reported among adults. SN - 0892-0362 UR - https://www.unboundmedicine.com/medline/citation/15734276/Neuromotor_functions_in_Inuit_preschool_children_exposed_to_Pb_PCBs_and_Hg_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0892-0362(04)00153-9 DB - PRIME DP - Unbound Medicine ER -