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Verbal episodic memory impairment in Alzheimer's disease: a combined structural and functional MRI study.
Neuroimage. 2005 Mar; 25(1):253-66.N

Abstract

Anatomical and functional MRI images were acquired in a group of healthy elderly subjects (n = 11) and a group of patients diagnosed with probable Alzheimer's disease, from mild to moderate severity (n = 8). During functional sessions, verbal episodic Encoding and Recognition tasks were presented to subjects. Both groups were compared in terms of gray matter volume and cerebral activation. Furthermore, in the AD group, correlations between hippocampal gray matter volume and whole-brain activations were examined. When compared to healthy controls, AD patients presented significant gray matter atrophy as well as reduced activations during Encoding and Recognition in the medial temporal lobes and inferior parietal/superior temporal associative areas. In the same regions, the fMRI activity elicited by the Recognition task was positively correlated with hippocampal gray matter volume. Moreover, an increase of left prefrontal activity during Encoding and Recognition was observed in AD patients relative to controls and was correlated with memory performance. This additional activity elicited by episodic memory processes was not found to correlate with the degree of medial temporal atrophy in our group of patients. Our study shows that function in brain regions critical to episodic memory is altered in AD. During episodic Recognition, these functional changes may closely correlate with the progressive structural changes observed in the hippocampal region.

Authors+Show Affiliations

MR Technology, Institute for Biodiagnostics, National Research Council, Winnipeg, Canada. florence.remy@faber.kuleuven.beNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15734360

Citation

Rémy, Florence, et al. "Verbal Episodic Memory Impairment in Alzheimer's Disease: a Combined Structural and Functional MRI Study." NeuroImage, vol. 25, no. 1, 2005, pp. 253-66.
Rémy F, Mirrashed F, Campbell B, et al. Verbal episodic memory impairment in Alzheimer's disease: a combined structural and functional MRI study. Neuroimage. 2005;25(1):253-66.
Rémy, F., Mirrashed, F., Campbell, B., & Richter, W. (2005). Verbal episodic memory impairment in Alzheimer's disease: a combined structural and functional MRI study. NeuroImage, 25(1), 253-66.
Rémy F, et al. Verbal Episodic Memory Impairment in Alzheimer's Disease: a Combined Structural and Functional MRI Study. Neuroimage. 2005;25(1):253-66. PubMed PMID: 15734360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Verbal episodic memory impairment in Alzheimer's disease: a combined structural and functional MRI study. AU - Rémy,Florence, AU - Mirrashed,Fakhereh, AU - Campbell,Barry, AU - Richter,Wolfgang, Y1 - 2004/12/10/ PY - 2004/08/17/received PY - 2004/10/07/revised PY - 2004/10/28/accepted PY - 2005/3/1/pubmed PY - 2005/5/25/medline PY - 2005/3/1/entrez SP - 253 EP - 66 JF - NeuroImage JO - Neuroimage VL - 25 IS - 1 N2 - Anatomical and functional MRI images were acquired in a group of healthy elderly subjects (n = 11) and a group of patients diagnosed with probable Alzheimer's disease, from mild to moderate severity (n = 8). During functional sessions, verbal episodic Encoding and Recognition tasks were presented to subjects. Both groups were compared in terms of gray matter volume and cerebral activation. Furthermore, in the AD group, correlations between hippocampal gray matter volume and whole-brain activations were examined. When compared to healthy controls, AD patients presented significant gray matter atrophy as well as reduced activations during Encoding and Recognition in the medial temporal lobes and inferior parietal/superior temporal associative areas. In the same regions, the fMRI activity elicited by the Recognition task was positively correlated with hippocampal gray matter volume. Moreover, an increase of left prefrontal activity during Encoding and Recognition was observed in AD patients relative to controls and was correlated with memory performance. This additional activity elicited by episodic memory processes was not found to correlate with the degree of medial temporal atrophy in our group of patients. Our study shows that function in brain regions critical to episodic memory is altered in AD. During episodic Recognition, these functional changes may closely correlate with the progressive structural changes observed in the hippocampal region. SN - 1053-8119 UR - https://www.unboundmedicine.com/medline/citation/15734360/Verbal_episodic_memory_impairment_in_Alzheimer's_disease:_a_combined_structural_and_functional_MRI_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(04)00664-0 DB - PRIME DP - Unbound Medicine ER -