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Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function.
Eur Heart J. 2005 Jun; 26(12):1196-204.EH

Abstract

AIMS

Recent data suggest that the administration of bone marrow-derived stem cells (BMSC) might improve myocardial perfusion and left ventricular (LV) function after acute myocardial infarction (AMI). The aim of this study was to assess spontaneous mobilization of BMSC expressing the haematopoietic and endothelial progenitor cell-associated antigen CD34+ after AMI and its relation to post-infarction remodelling.

METHODS AND RESULTS

Peripheral blood concentration of CD34+ BMSC was measured by flow cytometry in 54 patients with AMI, 26 patients with chronic stable angina (CSA), and 43 normal healthy subjects. In patients with AMI, LV function was measured by 2D-echocardiography. Eighteen AMI patients were reassessed at 1 year. BMSC concentration was higher in patients with AMI (mean peak value: 7.04+/-6.27 cells/microL), than in patients with CSA (3.80+/-2.12 cells/microL, P=0.036) and in healthy controls (1.87+/-1.52 cells/microL, P<0.001). At multivariable analysis statin use (P<0.001), primary percutaneous intervention (P=0.048) and anterior AMI (P=0.05) were the only independent predictors of increased BMSC mobilization after AMI. In the 28 patients without subsequent acute coronary events reassessed at 1 year follow-up, CD34+ cell concentration was an independent predictor of global and regional improvement of LV function (r=0.52, P=0.004 and r=-0.41, P=0.03, respectively).

CONCLUSION

AMI is followed by enhanced spontaneous mobilization of BMSC, in particular, in patients on statin therapy and following a primary percutaneous intervention. More importantly persistent spontaneous mobilization of BMSC might contribute to determine a more favourable post-AMI remodelling.

Authors+Show Affiliations

Institute of Cardiology, Catholic University of the Sacred Heart, Largo A. Gemelli 8, 00168 Rome, Italy. antoniomarialeone@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15734770

Citation

Leone, Antonio Maria, et al. "Mobilization of Bone Marrow-derived Stem Cells After Myocardial Infarction and Left Ventricular Function." European Heart Journal, vol. 26, no. 12, 2005, pp. 1196-204.
Leone AM, Rutella S, Bonanno G, et al. Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function. Eur Heart J. 2005;26(12):1196-204.
Leone, A. M., Rutella, S., Bonanno, G., Abbate, A., Rebuzzi, A. G., Giovannini, S., Lombardi, M., Galiuto, L., Liuzzo, G., Andreotti, F., Lanza, G. A., Contemi, A. M., Leone, G., & Crea, F. (2005). Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function. European Heart Journal, 26(12), 1196-204.
Leone AM, et al. Mobilization of Bone Marrow-derived Stem Cells After Myocardial Infarction and Left Ventricular Function. Eur Heart J. 2005;26(12):1196-204. PubMed PMID: 15734770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function. AU - Leone,Antonio Maria, AU - Rutella,Sergio, AU - Bonanno,Giuseppina, AU - Abbate,Antonio, AU - Rebuzzi,Antonio G, AU - Giovannini,Silvia, AU - Lombardi,Mariaelena, AU - Galiuto,Leonarda, AU - Liuzzo,Giovanna, AU - Andreotti,Felicita, AU - Lanza,Gaetano A, AU - Contemi,Anna Maria, AU - Leone,Giuseppe, AU - Crea,Filippo, Y1 - 2005/02/25/ PY - 2005/3/1/pubmed PY - 2005/9/30/medline PY - 2005/3/1/entrez SP - 1196 EP - 204 JF - European heart journal JO - Eur Heart J VL - 26 IS - 12 N2 - AIMS: Recent data suggest that the administration of bone marrow-derived stem cells (BMSC) might improve myocardial perfusion and left ventricular (LV) function after acute myocardial infarction (AMI). The aim of this study was to assess spontaneous mobilization of BMSC expressing the haematopoietic and endothelial progenitor cell-associated antigen CD34+ after AMI and its relation to post-infarction remodelling. METHODS AND RESULTS: Peripheral blood concentration of CD34+ BMSC was measured by flow cytometry in 54 patients with AMI, 26 patients with chronic stable angina (CSA), and 43 normal healthy subjects. In patients with AMI, LV function was measured by 2D-echocardiography. Eighteen AMI patients were reassessed at 1 year. BMSC concentration was higher in patients with AMI (mean peak value: 7.04+/-6.27 cells/microL), than in patients with CSA (3.80+/-2.12 cells/microL, P=0.036) and in healthy controls (1.87+/-1.52 cells/microL, P<0.001). At multivariable analysis statin use (P<0.001), primary percutaneous intervention (P=0.048) and anterior AMI (P=0.05) were the only independent predictors of increased BMSC mobilization after AMI. In the 28 patients without subsequent acute coronary events reassessed at 1 year follow-up, CD34+ cell concentration was an independent predictor of global and regional improvement of LV function (r=0.52, P=0.004 and r=-0.41, P=0.03, respectively). CONCLUSION: AMI is followed by enhanced spontaneous mobilization of BMSC, in particular, in patients on statin therapy and following a primary percutaneous intervention. More importantly persistent spontaneous mobilization of BMSC might contribute to determine a more favourable post-AMI remodelling. SN - 0195-668X UR - https://www.unboundmedicine.com/medline/citation/15734770/Mobilization_of_bone_marrow_derived_stem_cells_after_myocardial_infarction_and_left_ventricular_function_ L2 - https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehi164 DB - PRIME DP - Unbound Medicine ER -