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Effect of dehydroepiandrosterone replacement on insulin sensitivity and lipids in hypoadrenal women.
Diabetes. 2005 Mar; 54(3):765-9.D

Abstract

DHEA (dehydroepiandrosterone) replacement is not part of the current standard of care in hypoadrenal subjects. Animal studies have shown that DHEA administration prevents diabetes. To determine the physiological effect of DHEA replacement on insulin sensitivity in adrenal-deficient women, we performed a single-center, randomized, double-blind, placebo-controlled, crossover study in 28 hypoadrenal women (mean age 50.2 +/- 2.87 years) who received a single 50-mg dose of DHEA daily or placebo. After 12 weeks, insulin sensitivity was assessed using a hyperinsulinemic-euglycemic clamp. DHEA replacement significantly increased DHEA-S (sulfated ester of DHEA), bioavailable testosterone, and androstenedione and reduced sex hormone-binding globulin levels. Fasting plasma insulin and glucagon were lower with DHEA (42 +/- 4.94 vs. 53 +/- 6.58 pmol/l [P = 0.005] and 178 +/- 11.32 vs. 195.04 +/- 15 pmol/l [P = 0.02], respectively). The average amount of glucose needed to maintain similar blood glucose levels while infusing the same insulin dosages was higher during DHEA administration (358 +/- 24.7 vs. 320 +/- 24.6 mg/min; P < 0.05), whereas endogenous glucose production was similar. DHEA also reduced total cholesterol (P < 0.005), triglycerides (P < 0.011), LDL cholesterol (P < 0.05), and HDL cholesterol (P < 0.005). In conclusion, replacement therapy with 50 mg of DHEA for 12 weeks significantly increased insulin sensitivity in hypoadrenal women, thereby suggesting that DHEA replacement could have a potential impact in preventing type 2 diabetes.

Authors+Show Affiliations

Endocrine Research Unit, Joseph 5-194, Mayo Clinic and Foundation, 200 First St., SW, Rochester, MN 55905, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15734854

Citation

Dhatariya, Ketan, et al. "Effect of Dehydroepiandrosterone Replacement On Insulin Sensitivity and Lipids in Hypoadrenal Women." Diabetes, vol. 54, no. 3, 2005, pp. 765-9.
Dhatariya K, Bigelow ML, Nair KS. Effect of dehydroepiandrosterone replacement on insulin sensitivity and lipids in hypoadrenal women. Diabetes. 2005;54(3):765-9.
Dhatariya, K., Bigelow, M. L., & Nair, K. S. (2005). Effect of dehydroepiandrosterone replacement on insulin sensitivity and lipids in hypoadrenal women. Diabetes, 54(3), 765-9.
Dhatariya K, Bigelow ML, Nair KS. Effect of Dehydroepiandrosterone Replacement On Insulin Sensitivity and Lipids in Hypoadrenal Women. Diabetes. 2005;54(3):765-9. PubMed PMID: 15734854.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of dehydroepiandrosterone replacement on insulin sensitivity and lipids in hypoadrenal women. AU - Dhatariya,Ketan, AU - Bigelow,Maureen L, AU - Nair,K Sreekumaran, PY - 2005/3/1/pubmed PY - 2005/4/23/medline PY - 2005/3/1/entrez SP - 765 EP - 9 JF - Diabetes JO - Diabetes VL - 54 IS - 3 N2 - DHEA (dehydroepiandrosterone) replacement is not part of the current standard of care in hypoadrenal subjects. Animal studies have shown that DHEA administration prevents diabetes. To determine the physiological effect of DHEA replacement on insulin sensitivity in adrenal-deficient women, we performed a single-center, randomized, double-blind, placebo-controlled, crossover study in 28 hypoadrenal women (mean age 50.2 +/- 2.87 years) who received a single 50-mg dose of DHEA daily or placebo. After 12 weeks, insulin sensitivity was assessed using a hyperinsulinemic-euglycemic clamp. DHEA replacement significantly increased DHEA-S (sulfated ester of DHEA), bioavailable testosterone, and androstenedione and reduced sex hormone-binding globulin levels. Fasting plasma insulin and glucagon were lower with DHEA (42 +/- 4.94 vs. 53 +/- 6.58 pmol/l [P = 0.005] and 178 +/- 11.32 vs. 195.04 +/- 15 pmol/l [P = 0.02], respectively). The average amount of glucose needed to maintain similar blood glucose levels while infusing the same insulin dosages was higher during DHEA administration (358 +/- 24.7 vs. 320 +/- 24.6 mg/min; P < 0.05), whereas endogenous glucose production was similar. DHEA also reduced total cholesterol (P < 0.005), triglycerides (P < 0.011), LDL cholesterol (P < 0.05), and HDL cholesterol (P < 0.005). In conclusion, replacement therapy with 50 mg of DHEA for 12 weeks significantly increased insulin sensitivity in hypoadrenal women, thereby suggesting that DHEA replacement could have a potential impact in preventing type 2 diabetes. SN - 0012-1797 UR - https://www.unboundmedicine.com/medline/citation/15734854/Effect_of_dehydroepiandrosterone_replacement_on_insulin_sensitivity_and_lipids_in_hypoadrenal_women_ L2 - https://diabetes.diabetesjournals.org/lookup/pmidlookup?view=long&amp;pmid=15734854 DB - PRIME DP - Unbound Medicine ER -