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Soluble epidermal growth factor receptor (sEGFR) [corrected] and cancer antigen 125 (CA125) as screening and diagnostic tests for epithelial ovarian cancer.
Cancer Epidemiol Biomarkers Prev. 2005 Feb; 14(2):306-18.CE

Abstract

Epithelial ovarian cancer (EOC) is the leading cause of death among all gynecologic cancers in the United States. Because women who are diagnosed with early stage disease have a better prognosis than women diagnosed with late stage disease, early detection represents a potentially practical approach to reduce the mortality associated with EOC. Unfortunately, no single screening test has proven to be effective for this purpose, and a valid and feasible screening program to detect early stage EOC in the general population has not yet been devised. Consequently, research has focused on coupling two or more screening modalities to improve program validity and feasibility. Serum cancer antigen 125 (CA125) and a soluble isoform of the epidermal growth factor receptor (p110 sEGFR) have been studied individually as biomarkers of ovarian cancer. In this study, we compare serum CA125 levels and sEGFR concentrations in women with EOC to women with benign gynecologic conditions of ovarian and non-ovarian origin. We show that serum sEGFR concentrations are lower in patients with EOC than in women with benign gynecologic conditions, whereas serum CA125 levels are higher in patients to EOC compared with women with benign gynecologic conditions. These data also reveal that age and serum sEGFR concentrations modify the association between CA125 levels and EOC versus benign gynecologic disease. Hence, age- and sEGFR-dependent CA125 cutoff thresholds improve the ability of CA125 to discern EOC patients from women with benign ovarian tumors and non-ovarian gynecologic conditions. Our analyses show that parallel testing with fixed sEGFR and CA125 cutoff thresholds optimizes sensitivity to detect EOC, whereas serial testing with age- and sEGFR-dependent CA125 cutoff thresholds optimizes test specificity, and overall accuracy to discern patients with EOC from women with benign ovarian and non-ovarian gynecologic conditions. The combined use of serologic sEGFR and CA125, thus, has improved utility for screening and diagnosing EOC, which may increase the positive predictive value of a multimodal screening program that incorporates these biomarkers to detect and subsequently differentiate benign from malignant ovarian tumors.

Authors+Show Affiliations

Baron AT
Department of Internal Medicine, Division of Hematology/Oncology, Lucille P. Markey Cancer Center, University of Kentucky, 408 Roach Building, 800 Rose Street, Lexington, KY 40536-0093, USA. a.baron@uky.edu
Boardman CH
No affiliation info available
Lafky JM
No affiliation info available
Rademaker A
No affiliation info available
Liu D
No affiliation info available
Fishman DA
No affiliation info available
Podratz KC
No affiliation info available
Maihle NJ
No affiliation info available

MeSH

AdultAgedAged, 80 and overBiomarkers, TumorCA-125 AntigenEnzyme-Linked Immunosorbent AssayErbB ReceptorsFemaleHumansImmunosorbent TechniquesMass ScreeningMiddle AgedOvarian NeoplasmsProtein IsoformsSensitivity and Specificity

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15734951

Citation

Baron, Andre T., et al. "Soluble Epidermal Growth Factor Receptor (sEGFR) [corrected] and Cancer Antigen 125 (CA125) as Screening and Diagnostic Tests for Epithelial Ovarian Cancer." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 14, no. 2, 2005, pp. 306-18.
Baron AT, Boardman CH, Lafky JM, et al. Soluble epidermal growth factor receptor (sEGFR) [corrected] and cancer antigen 125 (CA125) as screening and diagnostic tests for epithelial ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2005;14(2):306-18.
Baron, A. T., Boardman, C. H., Lafky, J. M., Rademaker, A., Liu, D., Fishman, D. A., Podratz, K. C., & Maihle, N. J. (2005). Soluble epidermal growth factor receptor (sEGFR) [corrected] and cancer antigen 125 (CA125) as screening and diagnostic tests for epithelial ovarian cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 14(2), 306-18.
Baron AT, et al. Soluble Epidermal Growth Factor Receptor (sEGFR) [corrected] and Cancer Antigen 125 (CA125) as Screening and Diagnostic Tests for Epithelial Ovarian Cancer. Cancer Epidemiol Biomarkers Prev. 2005;14(2):306-18. PubMed PMID: 15734951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soluble epidermal growth factor receptor (sEGFR) [corrected] and cancer antigen 125 (CA125) as screening and diagnostic tests for epithelial ovarian cancer. AU - Baron,Andre T, AU - Boardman,Cecelia H, AU - Lafky,Jacqueline M, AU - Rademaker,Alfred, AU - Liu,Dachao, AU - Fishman,David A, AU - Podratz,Karl C, AU - Maihle,Nita J, PY - 2005/3/1/pubmed PY - 2005/6/3/medline PY - 2005/3/1/entrez SP - 306 EP - 18 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 14 IS - 2 N2 - Epithelial ovarian cancer (EOC) is the leading cause of death among all gynecologic cancers in the United States. Because women who are diagnosed with early stage disease have a better prognosis than women diagnosed with late stage disease, early detection represents a potentially practical approach to reduce the mortality associated with EOC. Unfortunately, no single screening test has proven to be effective for this purpose, and a valid and feasible screening program to detect early stage EOC in the general population has not yet been devised. Consequently, research has focused on coupling two or more screening modalities to improve program validity and feasibility. Serum cancer antigen 125 (CA125) and a soluble isoform of the epidermal growth factor receptor (p110 sEGFR) have been studied individually as biomarkers of ovarian cancer. In this study, we compare serum CA125 levels and sEGFR concentrations in women with EOC to women with benign gynecologic conditions of ovarian and non-ovarian origin. We show that serum sEGFR concentrations are lower in patients with EOC than in women with benign gynecologic conditions, whereas serum CA125 levels are higher in patients to EOC compared with women with benign gynecologic conditions. These data also reveal that age and serum sEGFR concentrations modify the association between CA125 levels and EOC versus benign gynecologic disease. Hence, age- and sEGFR-dependent CA125 cutoff thresholds improve the ability of CA125 to discern EOC patients from women with benign ovarian tumors and non-ovarian gynecologic conditions. Our analyses show that parallel testing with fixed sEGFR and CA125 cutoff thresholds optimizes sensitivity to detect EOC, whereas serial testing with age- and sEGFR-dependent CA125 cutoff thresholds optimizes test specificity, and overall accuracy to discern patients with EOC from women with benign ovarian and non-ovarian gynecologic conditions. The combined use of serologic sEGFR and CA125, thus, has improved utility for screening and diagnosing EOC, which may increase the positive predictive value of a multimodal screening program that incorporates these biomarkers to detect and subsequently differentiate benign from malignant ovarian tumors. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/15734951/Soluble_epidermal_growth_factor_receptor__sEGFR__[corrected]_and_cancer_antigen_125__CA125__as_screening_and_diagnostic_tests_for_epithelial_ovarian_cancer_ DB - PRIME DP - Unbound Medicine ER -