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Dietary factors and risk of non-hodgkin lymphoma in men and women.

Abstract

BACKGROUND

The incidence of non-Hodgkin lymphoma (NHL) has increased worldwide in recent decades. Diet could influence NHL risk by modulating the immune system, although evidence is limited. We did a population-based case-control study to determine whether differences in diet were associated with NHL risk.

METHODS

A total of 597 NHL cases and 467 population controls in Sweden completed a semiquantitative food frequency questionnaire evaluating their dietary habits 2 years before the interview. Unconditional logistic regression was used to estimate the odds ratios (OR) and corresponding 95% confidence intervals (95% CI) for associations between food intake and risk of NHL.

RESULTS

High consumption of dairy products and fried red meat was associated with increased risk of NHL. The OR of NHL for individuals in the highest quartile compared with the lowest quartile of dairy intake was 1.5 (95% CI, 1.1-2.2; P(trend) = 0.003). The OR for the highest versus lowest quartile of fried red meat intake was 1.5 (95% CI, 1.0-2.1; P(trend) = 0.02). In contrast, high consumption of fruits and vegetables was associated with reduced risk of NHL, particularly follicular lymphoma, among women but not men. Compared with the lowest quartile of vegetable intake, the OR of follicular lymphoma among women in the highest quartile of vegetable intake was 0.3 (95% CI, 0.1-0.7; P(trend) = 0.002).

CONCLUSIONS

The positive associations of NHL risk with dairy products and fried red meat and the inverse association with fruits and vegetables suggest that diet affects NHL risk and could explain the increase of some histopathogic subtypes.

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  • Authors+Show Affiliations

    ,

    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77 Stockholm, Sweden. ellen.chang@meb.ki.se

    , , , , , , ,

    Source

    MeSH

    Case-Control Studies
    Diet
    Diet Surveys
    Female
    Food
    Humans
    Logistic Models
    Lymphoma, Non-Hodgkin
    Male
    Middle Aged
    Risk Factors
    Sweden

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15734980

    Citation

    Chang, Ellen T., et al. "Dietary Factors and Risk of Non-hodgkin Lymphoma in Men and Women." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 14, no. 2, 2005, pp. 512-20.
    Chang ET, Smedby KE, Zhang SM, et al. Dietary factors and risk of non-hodgkin lymphoma in men and women. Cancer Epidemiol Biomarkers Prev. 2005;14(2):512-20.
    Chang, E. T., Smedby, K. E., Zhang, S. M., Hjalgrim, H., Melbye, M., Ost, A., ... Adami, H. O. (2005). Dietary factors and risk of non-hodgkin lymphoma in men and women. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 14(2), pp. 512-20.
    Chang ET, et al. Dietary Factors and Risk of Non-hodgkin Lymphoma in Men and Women. Cancer Epidemiol Biomarkers Prev. 2005;14(2):512-20. PubMed PMID: 15734980.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary factors and risk of non-hodgkin lymphoma in men and women. AU - Chang,Ellen T, AU - Smedby,Karin Ekström, AU - Zhang,Shumin M, AU - Hjalgrim,Henrik, AU - Melbye,Mads, AU - Ost,Ake, AU - Glimelius,Bengt, AU - Wolk,Alicja, AU - Adami,Hans-Olov, PY - 2005/3/1/pubmed PY - 2005/6/3/medline PY - 2005/3/1/entrez SP - 512 EP - 20 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 14 IS - 2 N2 - BACKGROUND: The incidence of non-Hodgkin lymphoma (NHL) has increased worldwide in recent decades. Diet could influence NHL risk by modulating the immune system, although evidence is limited. We did a population-based case-control study to determine whether differences in diet were associated with NHL risk. METHODS: A total of 597 NHL cases and 467 population controls in Sweden completed a semiquantitative food frequency questionnaire evaluating their dietary habits 2 years before the interview. Unconditional logistic regression was used to estimate the odds ratios (OR) and corresponding 95% confidence intervals (95% CI) for associations between food intake and risk of NHL. RESULTS: High consumption of dairy products and fried red meat was associated with increased risk of NHL. The OR of NHL for individuals in the highest quartile compared with the lowest quartile of dairy intake was 1.5 (95% CI, 1.1-2.2; P(trend) = 0.003). The OR for the highest versus lowest quartile of fried red meat intake was 1.5 (95% CI, 1.0-2.1; P(trend) = 0.02). In contrast, high consumption of fruits and vegetables was associated with reduced risk of NHL, particularly follicular lymphoma, among women but not men. Compared with the lowest quartile of vegetable intake, the OR of follicular lymphoma among women in the highest quartile of vegetable intake was 0.3 (95% CI, 0.1-0.7; P(trend) = 0.002). CONCLUSIONS: The positive associations of NHL risk with dairy products and fried red meat and the inverse association with fruits and vegetables suggest that diet affects NHL risk and could explain the increase of some histopathogic subtypes. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/15734980/Dietary_factors_and_risk_of_non_hodgkin_lymphoma_in_men_and_women_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=15734980 DB - PRIME DP - Unbound Medicine ER -