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Hepatitis C virus coinfection and HIV load, CD4+ cell percentage, and clinical progression to AIDS or death among HIV-infected women: Women and Infants Transmission Study.
Clin Infect Dis. 2005 Mar 15; 40(6):859-67.CI

Abstract

BACKGROUND

Despite previous study, it remains unclear whether hepatitis C virus (HCV) coinfection affects the progression of human immunodeficiency virus (HIV) type 1 infection. The Women and Infants Transmission Study provided an opportunity to assess this issue.

METHODS

Longitudinal data on 652 HIV-1-infected women enrolled in the study before the availability of highly active antiretroviral therapy (HAART; 1989-1995) were analyzed. Random effects models were used to determine whether HCV coinfection was associated with different CD4+ cell percentages and HIV-1 RNA levels over time, and Cox proportional hazards models were used to compare the rates of clinical progression to acquired immunodeficiency syndrome (AIDS) or death.

RESULTS

Of 652 women, 190 (29%) were HCV infected. During follow-up, 19% of women were exposed to HAART. After controlling for indicators of disease progression (CD4+ cell percentages and HIV-1 RNA levels determined closest to the time of delivery in pregnant women), ongoing drug use, receipt of antiretroviral therapy, and other important covariates, no differences were detected in the HIV-1 RNA levels, but the CD4+ cell percentages were slightly higher in HCV-infected women than in HCV-uninfected women. During follow-up, 48 women had progression to a first clinical AIDS-defining illness (ADI), and 26 died with no documented antecedent ADI. In multivariable analyses, HCV-infected participants did not have faster progression to a first class C AIDS-defining event or death (relative hazard, 0.75; 95% confidence interval, 0.37-1.53).

CONCLUSIONS

In this cohort, the rate of clinical progression of HIV-1 infection was not greater for HCV-infected women.

Authors+Show Affiliations

University of Illinois at Chicago School of Public Health, Chicago, IL 60612, USA. rchersho@uic.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15736020

Citation

Hershow, Ronald C., et al. "Hepatitis C Virus Coinfection and HIV Load, CD4+ Cell Percentage, and Clinical Progression to AIDS or Death Among HIV-infected Women: Women and Infants Transmission Study." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 40, no. 6, 2005, pp. 859-67.
Hershow RC, O'Driscoll PT, Handelsman E, et al. Hepatitis C virus coinfection and HIV load, CD4+ cell percentage, and clinical progression to AIDS or death among HIV-infected women: Women and Infants Transmission Study. Clin Infect Dis. 2005;40(6):859-67.
Hershow, R. C., O'Driscoll, P. T., Handelsman, E., Pitt, J., Hillyer, G., Serchuck, L., Lu, M., Chen, K. T., Yawetz, S., Pacheco, S., Davenny, K., Adeniyi-Jones, S., & Thomas, D. L. (2005). Hepatitis C virus coinfection and HIV load, CD4+ cell percentage, and clinical progression to AIDS or death among HIV-infected women: Women and Infants Transmission Study. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 40(6), 859-67.
Hershow RC, et al. Hepatitis C Virus Coinfection and HIV Load, CD4+ Cell Percentage, and Clinical Progression to AIDS or Death Among HIV-infected Women: Women and Infants Transmission Study. Clin Infect Dis. 2005 Mar 15;40(6):859-67. PubMed PMID: 15736020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis C virus coinfection and HIV load, CD4+ cell percentage, and clinical progression to AIDS or death among HIV-infected women: Women and Infants Transmission Study. AU - Hershow,Ronald C, AU - O'Driscoll,Peter T, AU - Handelsman,Ed, AU - Pitt,Jane, AU - Hillyer,George, AU - Serchuck,Leslie, AU - Lu,Ming, AU - Chen,Katherine T, AU - Yawetz,Sigal, AU - Pacheco,Susan, AU - Davenny,Katherine, AU - Adeniyi-Jones,Samuel, AU - Thomas,David L, Y1 - 2005/02/18/ PY - 2004/08/12/received PY - 2004/10/28/accepted PY - 2005/3/1/pubmed PY - 2006/8/10/medline PY - 2005/3/1/entrez SP - 859 EP - 67 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 40 IS - 6 N2 - BACKGROUND: Despite previous study, it remains unclear whether hepatitis C virus (HCV) coinfection affects the progression of human immunodeficiency virus (HIV) type 1 infection. The Women and Infants Transmission Study provided an opportunity to assess this issue. METHODS: Longitudinal data on 652 HIV-1-infected women enrolled in the study before the availability of highly active antiretroviral therapy (HAART; 1989-1995) were analyzed. Random effects models were used to determine whether HCV coinfection was associated with different CD4+ cell percentages and HIV-1 RNA levels over time, and Cox proportional hazards models were used to compare the rates of clinical progression to acquired immunodeficiency syndrome (AIDS) or death. RESULTS: Of 652 women, 190 (29%) were HCV infected. During follow-up, 19% of women were exposed to HAART. After controlling for indicators of disease progression (CD4+ cell percentages and HIV-1 RNA levels determined closest to the time of delivery in pregnant women), ongoing drug use, receipt of antiretroviral therapy, and other important covariates, no differences were detected in the HIV-1 RNA levels, but the CD4+ cell percentages were slightly higher in HCV-infected women than in HCV-uninfected women. During follow-up, 48 women had progression to a first clinical AIDS-defining illness (ADI), and 26 died with no documented antecedent ADI. In multivariable analyses, HCV-infected participants did not have faster progression to a first class C AIDS-defining event or death (relative hazard, 0.75; 95% confidence interval, 0.37-1.53). CONCLUSIONS: In this cohort, the rate of clinical progression of HIV-1 infection was not greater for HCV-infected women. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/15736020/Hepatitis_C_virus_coinfection_and_HIV_load_CD4+_cell_percentage_and_clinical_progression_to_AIDS_or_death_among_HIV_infected_women:_Women_and_Infants_Transmission_Study_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/428121 DB - PRIME DP - Unbound Medicine ER -