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Insulin sensitivity indices of glucose and free fatty acid metabolism in obese children and adolescents in relation to serum lipids.
Metabolism. 2005 Mar; 54(3):397-402.M

Abstract

OBJECTIVE

Most studies concerning the association between insulin resistance and the features of metabolic syndrome in obese children are based on measurement of insulin sensitivity indices (ISI) of glucose metabolism and not of fat metabolism.

METHODS

We studied fasting low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, insulin, free fatty acids (FFA), blood glucose, ISI of glucose (homeostasis model assessment [HOMA] %S), and FFA metabolism (ISI-FFA) in 124 obese children aged 6 to 16 years. ISI-FFA was calculated based on the formula 2/(insulin x FFA + 1). Stepwise forward regression analyses were performed with triglycerides, HDL-C and LDL-C as dependent variables and age, sex, stage of puberty, body mass index, insulin, FFA, and blood glucose as independent variables. Direct multiple regression analyses were conducted with the dependent variables triglycerides, HDL-C, and LDL-C including age, sex, stage of puberty, body mass index, HOMA %S, and ISI-FFA as independent variables. Furthermore, ISI-FFA was measured in 13 normal-weight children aged 6 to 16 years.

RESULTS

ISI-FFA (median 0.30) was significantly (P < .05) reduced in obese children compared with normal-weight children (median ISI-FFA 0.64). In stepwise regression analyses, triglycerides were significantly correlated with insulin and FFA (P < .05), LDL-C levels were significantly correlated with FFA (P < .05), and HDL-C was related to stage of puberty (P < .05), whereas all other variables demonstrated no significant associations with triglycerides, LDL-C, and HDL-C levels. In contrast to HOMA %S, ISI-FFA was significantly (P < .05) related to triglycerides and LDL-C in direct multiple regression analysis.

CONCLUSIONS

Insulin resistance in respect to FFA metabolism is already detectable in childhood. Insulin sensitivity index of FFA metabolism seems to be a better tool for describing insulin resistance in lipid metabolism than ISI of glucose metabolism, because FFA and partially insulin but not glucose were related to triglycerides and LDL-C.

Authors+Show Affiliations

Vestische Hospital for Children and Adolescents, University of Witten-Herdecke, D-45711 Datteln, Germany. t.reinerhr@kinderklinik-datteln.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15736120

Citation

Reinehr, Thomas, et al. "Insulin Sensitivity Indices of Glucose and Free Fatty Acid Metabolism in Obese Children and Adolescents in Relation to Serum Lipids." Metabolism: Clinical and Experimental, vol. 54, no. 3, 2005, pp. 397-402.
Reinehr T, Kiess W, Andler W. Insulin sensitivity indices of glucose and free fatty acid metabolism in obese children and adolescents in relation to serum lipids. Metabolism. 2005;54(3):397-402.
Reinehr, T., Kiess, W., & Andler, W. (2005). Insulin sensitivity indices of glucose and free fatty acid metabolism in obese children and adolescents in relation to serum lipids. Metabolism: Clinical and Experimental, 54(3), 397-402.
Reinehr T, Kiess W, Andler W. Insulin Sensitivity Indices of Glucose and Free Fatty Acid Metabolism in Obese Children and Adolescents in Relation to Serum Lipids. Metabolism. 2005;54(3):397-402. PubMed PMID: 15736120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin sensitivity indices of glucose and free fatty acid metabolism in obese children and adolescents in relation to serum lipids. AU - Reinehr,Thomas, AU - Kiess,Wieland, AU - Andler,Werner, PY - 2005/3/1/pubmed PY - 2005/5/3/medline PY - 2005/3/1/entrez SP - 397 EP - 402 JF - Metabolism: clinical and experimental JO - Metabolism VL - 54 IS - 3 N2 - OBJECTIVE: Most studies concerning the association between insulin resistance and the features of metabolic syndrome in obese children are based on measurement of insulin sensitivity indices (ISI) of glucose metabolism and not of fat metabolism. METHODS: We studied fasting low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, insulin, free fatty acids (FFA), blood glucose, ISI of glucose (homeostasis model assessment [HOMA] %S), and FFA metabolism (ISI-FFA) in 124 obese children aged 6 to 16 years. ISI-FFA was calculated based on the formula 2/(insulin x FFA + 1). Stepwise forward regression analyses were performed with triglycerides, HDL-C and LDL-C as dependent variables and age, sex, stage of puberty, body mass index, insulin, FFA, and blood glucose as independent variables. Direct multiple regression analyses were conducted with the dependent variables triglycerides, HDL-C, and LDL-C including age, sex, stage of puberty, body mass index, HOMA %S, and ISI-FFA as independent variables. Furthermore, ISI-FFA was measured in 13 normal-weight children aged 6 to 16 years. RESULTS: ISI-FFA (median 0.30) was significantly (P < .05) reduced in obese children compared with normal-weight children (median ISI-FFA 0.64). In stepwise regression analyses, triglycerides were significantly correlated with insulin and FFA (P < .05), LDL-C levels were significantly correlated with FFA (P < .05), and HDL-C was related to stage of puberty (P < .05), whereas all other variables demonstrated no significant associations with triglycerides, LDL-C, and HDL-C levels. In contrast to HOMA %S, ISI-FFA was significantly (P < .05) related to triglycerides and LDL-C in direct multiple regression analysis. CONCLUSIONS: Insulin resistance in respect to FFA metabolism is already detectable in childhood. Insulin sensitivity index of FFA metabolism seems to be a better tool for describing insulin resistance in lipid metabolism than ISI of glucose metabolism, because FFA and partially insulin but not glucose were related to triglycerides and LDL-C. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/15736120/Insulin_sensitivity_indices_of_glucose_and_free_fatty_acid_metabolism_in_obese_children_and_adolescents_in_relation_to_serum_lipids_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026049504003968 DB - PRIME DP - Unbound Medicine ER -