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Chitosan hydrochloride based microspheres of albendazole for colonic drug delivery.
Pharmazie. 2005 Feb; 60(2):131-4.P

Abstract

Microspheres of chitosan hydrochloride (CH) were prepared in order to deliver albendazole specifically into the colon. Microspheres were prepared by an emulsion method using different ratios of drug and CH (1:1 to 1:5), agitation speeds (500 to 1500 rpm) and concentrations of glutaraldehyde in toluene as the cross-linking agent (0.25 to 1.0% w/v). The effect of polymer concentration, stirring rate and concentration of cross-linking agent on the particle size and drug loading was studied. With an increase in CH concentration, the average particle size was increased. Increased agitation speed reduced the size of the microspheres but higher agitation speed resulted in irregularly shaped microspheres. Increasing the concentration of cross-linking agent produced more regularly shaped microspheres of smaller size. The drug loading was highest at a drug: CH ratio of 1:3, stirring speed 1000 rpm and 0.75% w/v concentration of cross-linking agent. The effect of CH concentration on in vitro drug release from the microspheres was evaluated in simulated g.i.t fluids. A comparative in vitro drug release study of the optimized formulation was carried out in simulated colonic fluid, with and without 2% rat caecal content. The drug release in 24 h was 48.9% in colonic fluid without rat caecal content, and 76.5% in colonic fluid with rat caecal contents.

Authors+Show Affiliations

Pharmaceutical Research Laboratory, Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15739902

Citation

Rai, G, et al. "Chitosan Hydrochloride Based Microspheres of Albendazole for Colonic Drug Delivery." Die Pharmazie, vol. 60, no. 2, 2005, pp. 131-4.
Rai G, Jain SK, Agrawal S, et al. Chitosan hydrochloride based microspheres of albendazole for colonic drug delivery. Pharmazie. 2005;60(2):131-4.
Rai, G., Jain, S. K., Agrawal, S., Bhadra, S., Pancholi, S. S., & Agrawal, G. P. (2005). Chitosan hydrochloride based microspheres of albendazole for colonic drug delivery. Die Pharmazie, 60(2), 131-4.
Rai G, et al. Chitosan Hydrochloride Based Microspheres of Albendazole for Colonic Drug Delivery. Pharmazie. 2005;60(2):131-4. PubMed PMID: 15739902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chitosan hydrochloride based microspheres of albendazole for colonic drug delivery. AU - Rai,G, AU - Jain,S K, AU - Agrawal,S, AU - Bhadra,S, AU - Pancholi,S S, AU - Agrawal,G P, PY - 2005/3/3/pubmed PY - 2005/4/2/medline PY - 2005/3/3/entrez SP - 131 EP - 4 JF - Die Pharmazie JO - Pharmazie VL - 60 IS - 2 N2 - Microspheres of chitosan hydrochloride (CH) were prepared in order to deliver albendazole specifically into the colon. Microspheres were prepared by an emulsion method using different ratios of drug and CH (1:1 to 1:5), agitation speeds (500 to 1500 rpm) and concentrations of glutaraldehyde in toluene as the cross-linking agent (0.25 to 1.0% w/v). The effect of polymer concentration, stirring rate and concentration of cross-linking agent on the particle size and drug loading was studied. With an increase in CH concentration, the average particle size was increased. Increased agitation speed reduced the size of the microspheres but higher agitation speed resulted in irregularly shaped microspheres. Increasing the concentration of cross-linking agent produced more regularly shaped microspheres of smaller size. The drug loading was highest at a drug: CH ratio of 1:3, stirring speed 1000 rpm and 0.75% w/v concentration of cross-linking agent. The effect of CH concentration on in vitro drug release from the microspheres was evaluated in simulated g.i.t fluids. A comparative in vitro drug release study of the optimized formulation was carried out in simulated colonic fluid, with and without 2% rat caecal content. The drug release in 24 h was 48.9% in colonic fluid without rat caecal content, and 76.5% in colonic fluid with rat caecal contents. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/15739902/Chitosan_hydrochloride_based_microspheres_of_albendazole_for_colonic_drug_delivery_ DB - PRIME DP - Unbound Medicine ER -