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Effect of an aqueous extract of Scoparia dulcis on plasma and tissue glycoproteins in streptozotocin induced diabetic rats.
Pharmazie. 2005 Feb; 60(2):151-4.P

Abstract

The influence of Scoparia dulcis, a traditionally used plant for the treatment of diabetes mellitus, was examined in streptozotocin diabetic rats on dearrangement in glycoprotein levels. Diabetes was induced in male Wistar rats by a single intraperitoneal injection of streptozotocin. An aqueous extract of Scoparia dulcis plant was administered orally for 6 weeks. The effect of the Scoparia dulcis extract on blood glucose, plasma insulin, plasma and tissue glycoproteins studied was in comparison to glibenclamide. The levels of blood glucose and plasma glycoproteins were increased significantly whereas the level of plasma insulin was significantly decreased in diabetic rats. There was a significant decrease in the level of sialic acid and elevated levels of hexose, hexosamine and fucose in the liver and kidney of streptozotocin diabetic rats. Oral administration of Scoparia dulcis plant extract (SPEt) to diabetic rats led to decreased levels of blood glucose and plasma glycoproteins. The levels of plasma insulin and tissue sialic acid were increased whereas the levels of tissue hexose, hexosamine and fucose were near normal. The present study indicates that Scoparia dulcis possesses a significant beneficial effect on glycoproteins in addition to its antidiabetic effect.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15739907

Citation

Latha, M, and L Pari. "Effect of an Aqueous Extract of Scoparia Dulcis On Plasma and Tissue Glycoproteins in Streptozotocin Induced Diabetic Rats." Die Pharmazie, vol. 60, no. 2, 2005, pp. 151-4.
Latha M, Pari L. Effect of an aqueous extract of Scoparia dulcis on plasma and tissue glycoproteins in streptozotocin induced diabetic rats. Pharmazie. 2005;60(2):151-4.
Latha, M., & Pari, L. (2005). Effect of an aqueous extract of Scoparia dulcis on plasma and tissue glycoproteins in streptozotocin induced diabetic rats. Die Pharmazie, 60(2), 151-4.
Latha M, Pari L. Effect of an Aqueous Extract of Scoparia Dulcis On Plasma and Tissue Glycoproteins in Streptozotocin Induced Diabetic Rats. Pharmazie. 2005;60(2):151-4. PubMed PMID: 15739907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of an aqueous extract of Scoparia dulcis on plasma and tissue glycoproteins in streptozotocin induced diabetic rats. AU - Latha,M, AU - Pari,L, PY - 2005/3/3/pubmed PY - 2005/4/2/medline PY - 2005/3/3/entrez SP - 151 EP - 4 JF - Die Pharmazie JO - Pharmazie VL - 60 IS - 2 N2 - The influence of Scoparia dulcis, a traditionally used plant for the treatment of diabetes mellitus, was examined in streptozotocin diabetic rats on dearrangement in glycoprotein levels. Diabetes was induced in male Wistar rats by a single intraperitoneal injection of streptozotocin. An aqueous extract of Scoparia dulcis plant was administered orally for 6 weeks. The effect of the Scoparia dulcis extract on blood glucose, plasma insulin, plasma and tissue glycoproteins studied was in comparison to glibenclamide. The levels of blood glucose and plasma glycoproteins were increased significantly whereas the level of plasma insulin was significantly decreased in diabetic rats. There was a significant decrease in the level of sialic acid and elevated levels of hexose, hexosamine and fucose in the liver and kidney of streptozotocin diabetic rats. Oral administration of Scoparia dulcis plant extract (SPEt) to diabetic rats led to decreased levels of blood glucose and plasma glycoproteins. The levels of plasma insulin and tissue sialic acid were increased whereas the levels of tissue hexose, hexosamine and fucose were near normal. The present study indicates that Scoparia dulcis possesses a significant beneficial effect on glycoproteins in addition to its antidiabetic effect. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/15739907/Effect_of_an_aqueous_extract_of_Scoparia_dulcis_on_plasma_and_tissue_glycoproteins_in_streptozotocin_induced_diabetic_rats_ DB - PRIME DP - Unbound Medicine ER -