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Depression and chronic obstructive pulmonary disease (COPD). Impact on survival.
Acta Psychiatr Scand 2005; 111(4):320-3AP

Abstract

OBJECTIVE

To determine if the presence of depression in patients suffering from chronic obstructive pulmonary disease (COPD) would have an independent impact on mortality.

METHOD

Prospective evaluation of the impact of depression according to the ICD-10 criteria for depression. Cox proportional hazards regression was used to evaluate the independent impact of depression after controlling for significant univariate clinical predictors in the data set. Consenting out-patients (n = 49) who meet the criteria for COPD between September 1997 and September 1998. There were no age limits (range: 53-90 years). The sample was 67% female. Survival status at follow-up after a mean of 803 days was measured.

RESULTS

At follow-up, 16 patients had died. Depression significantly reduced the mortality risk at follow-up (hazard ratio, 0.30; 95% confidence interval, 0.10-0.93; P = 0.037). The impact of depression remained after control for forced expiratory volume during the first second (FEV1), the only multivariate significant predictor of mortality in the data set (hazard ratio, 0.27; 95% confidence interval, 0.09-0.84; P = 0.024).

CONCLUSION

Depression in out-patients suffering from COPD appears to be an independent protector for mortality. Additional studies in larger samples are needed to replicate this finding and to determine possible underlying pathogenetic mechanisms.

Authors+Show Affiliations

Department of Psychiatry, Odense University Hospital, Odense C, Denmark.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15740469

Citation

Stage, K B., et al. "Depression and Chronic Obstructive Pulmonary Disease (COPD). Impact On Survival." Acta Psychiatrica Scandinavica, vol. 111, no. 4, 2005, pp. 320-3.
Stage KB, Middelboe T, Pisinger C. Depression and chronic obstructive pulmonary disease (COPD). Impact on survival. Acta Psychiatr Scand. 2005;111(4):320-3.
Stage, K. B., Middelboe, T., & Pisinger, C. (2005). Depression and chronic obstructive pulmonary disease (COPD). Impact on survival. Acta Psychiatrica Scandinavica, 111(4), pp. 320-3.
Stage KB, Middelboe T, Pisinger C. Depression and Chronic Obstructive Pulmonary Disease (COPD). Impact On Survival. Acta Psychiatr Scand. 2005;111(4):320-3. PubMed PMID: 15740469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depression and chronic obstructive pulmonary disease (COPD). Impact on survival. AU - Stage,K B, AU - Middelboe,T, AU - Pisinger,C, PY - 2005/3/3/pubmed PY - 2005/9/10/medline PY - 2005/3/3/entrez SP - 320 EP - 3 JF - Acta psychiatrica Scandinavica JO - Acta Psychiatr Scand VL - 111 IS - 4 N2 - OBJECTIVE: To determine if the presence of depression in patients suffering from chronic obstructive pulmonary disease (COPD) would have an independent impact on mortality. METHOD: Prospective evaluation of the impact of depression according to the ICD-10 criteria for depression. Cox proportional hazards regression was used to evaluate the independent impact of depression after controlling for significant univariate clinical predictors in the data set. Consenting out-patients (n = 49) who meet the criteria for COPD between September 1997 and September 1998. There were no age limits (range: 53-90 years). The sample was 67% female. Survival status at follow-up after a mean of 803 days was measured. RESULTS: At follow-up, 16 patients had died. Depression significantly reduced the mortality risk at follow-up (hazard ratio, 0.30; 95% confidence interval, 0.10-0.93; P = 0.037). The impact of depression remained after control for forced expiratory volume during the first second (FEV1), the only multivariate significant predictor of mortality in the data set (hazard ratio, 0.27; 95% confidence interval, 0.09-0.84; P = 0.024). CONCLUSION: Depression in out-patients suffering from COPD appears to be an independent protector for mortality. Additional studies in larger samples are needed to replicate this finding and to determine possible underlying pathogenetic mechanisms. SN - 0001-690X UR - https://www.unboundmedicine.com/medline/citation/15740469/Depression_and_chronic_obstructive_pulmonary_disease__COPD___Impact_on_survival_ L2 - https://doi.org/10.1111/j.1600-0447.2004.00497.x DB - PRIME DP - Unbound Medicine ER -