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Does L-arginine induce intestinal adaptation by epithelial growth factor?
ANZ J Surg. 2005 Jan-Feb; 75(1-2):73-5.AJ

Abstract

BACKGROUND

To evaluate whether L-Arginine has an effect on endogenous epidermal growth factor secretion and intestinal adaptation in massive small bowel resection an experimental study was performed.

METHODS

Fourteen albino Wistar rats weighing 250-300 g were used for the study. After performing 50% small bowel resection and anastomosis the rats were randomly divided into two groups. The first group received 500 mg/kg/day of L-Arginine intraperitoneally for 14 days just after the surgical procedure. The control group received isotonic saline instead. Body weight measurement was preformed daily. At the end of the second postoperative week all rats underwent relaparotomy. Small bowel was resected for histopathological examination. Levels of epidermal growth factor were measured by enzyme-linked immunosorbent assay in serum, saliva, and urine at the end of second postoperative week in both groups.

RESULTS

The weight gain was higher in the L-Arginine treated group (P < 0.05). Serum, saliva and urinary epidermal growth factor levels were significantly higher at the end of the second week compared to the control group (P < 0.05). The villus height was higher on histopathological examination in L-Arginine treated group compared to the control group (P < 0.05).

CONCLUSION

L-Arginine resulted in a better intestinal adaptation after massive bowel resection. The high levels of epidermal growth factor in body fluids of L-Arginine treated rats could be the explanation for this effect.

Authors+Show Affiliations

Department of Paediatric Surgery, Ankara University, School of Medicine, Ankara 06100, Turkey.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15740521

Citation

Camli, Alparslan, et al. "Does L-arginine Induce Intestinal Adaptation By Epithelial Growth Factor?" ANZ Journal of Surgery, vol. 75, no. 1-2, 2005, pp. 73-5.
Camli A, Barlas M, Yagmurlu A. Does L-arginine induce intestinal adaptation by epithelial growth factor? ANZ J Surg. 2005;75(1-2):73-5.
Camli, A., Barlas, M., & Yagmurlu, A. (2005). Does L-arginine induce intestinal adaptation by epithelial growth factor? ANZ Journal of Surgery, 75(1-2), 73-5.
Camli A, Barlas M, Yagmurlu A. Does L-arginine Induce Intestinal Adaptation By Epithelial Growth Factor. ANZ J Surg. 2005 Jan-Feb;75(1-2):73-5. PubMed PMID: 15740521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does L-arginine induce intestinal adaptation by epithelial growth factor? AU - Camli,Alparslan, AU - Barlas,Meral, AU - Yagmurlu,Aydin, PY - 2005/3/3/pubmed PY - 2005/7/1/medline PY - 2005/3/3/entrez SP - 73 EP - 5 JF - ANZ journal of surgery JO - ANZ J Surg VL - 75 IS - 1-2 N2 - BACKGROUND: To evaluate whether L-Arginine has an effect on endogenous epidermal growth factor secretion and intestinal adaptation in massive small bowel resection an experimental study was performed. METHODS: Fourteen albino Wistar rats weighing 250-300 g were used for the study. After performing 50% small bowel resection and anastomosis the rats were randomly divided into two groups. The first group received 500 mg/kg/day of L-Arginine intraperitoneally for 14 days just after the surgical procedure. The control group received isotonic saline instead. Body weight measurement was preformed daily. At the end of the second postoperative week all rats underwent relaparotomy. Small bowel was resected for histopathological examination. Levels of epidermal growth factor were measured by enzyme-linked immunosorbent assay in serum, saliva, and urine at the end of second postoperative week in both groups. RESULTS: The weight gain was higher in the L-Arginine treated group (P < 0.05). Serum, saliva and urinary epidermal growth factor levels were significantly higher at the end of the second week compared to the control group (P < 0.05). The villus height was higher on histopathological examination in L-Arginine treated group compared to the control group (P < 0.05). CONCLUSION: L-Arginine resulted in a better intestinal adaptation after massive bowel resection. The high levels of epidermal growth factor in body fluids of L-Arginine treated rats could be the explanation for this effect. SN - 1445-1433 UR - https://www.unboundmedicine.com/medline/citation/15740521/Does_L_arginine_induce_intestinal_adaptation_by_epithelial_growth_factor L2 - https://doi.org/10.1111/j.1445-2197.2005.03298.x DB - PRIME DP - Unbound Medicine ER -