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In vivo glucose monitoring: the clinical reality and the promise.
Biosens Bioelectron. 2005 Apr 15; 20(10):1897-902.BB

Abstract

Glucose monitoring is an essential component of modern diabetes management. Three in vivo glucose sensors are now available for clinical use: a subcutaneously implanted amperometric enzyme electrode, a reverse iontophoresis system and a microdialysis-based device. Improvements in glucose-sensing technology continue to be sought, e.g. wired enzyme technology, viscometric affinity sensing and totally implanted glucose sensors. Non-invasive glucose sensing is the ultimate goal of glucose monitoring, but the most investigated approach, near-infrared (NIR) spectroscopy, is presently too imprecise for clinical application. Fluorescence-based glucose sensing offers several advantages and we are investigating strategies which include NIR-based fluorescence resonance energy transfer using concanavalin A/dextran; changes in the intrinsic fluorescence of hexokinase encapsulated in sol-gel; and non-invasive glucose monitoring of cells by measuring glucose-related changes in NADP(H).

Authors+Show Affiliations

Metabolic Unit, Guy's, King's and St Thomas's School of Medicine, Guy's Hospital, 5th Floor Thomas Guy House, London SE1 9RT, UK. john.pickup@kcl.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15741056

Citation

Pickup, John C., et al. "In Vivo Glucose Monitoring: the Clinical Reality and the Promise." Biosensors & Bioelectronics, vol. 20, no. 10, 2005, pp. 1897-902.
Pickup JC, Hussain F, Evans ND, et al. In vivo glucose monitoring: the clinical reality and the promise. Biosens Bioelectron. 2005;20(10):1897-902.
Pickup, J. C., Hussain, F., Evans, N. D., & Sachedina, N. (2005). In vivo glucose monitoring: the clinical reality and the promise. Biosensors & Bioelectronics, 20(10), 1897-902.
Pickup JC, et al. In Vivo Glucose Monitoring: the Clinical Reality and the Promise. Biosens Bioelectron. 2005 Apr 15;20(10):1897-902. PubMed PMID: 15741056.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo glucose monitoring: the clinical reality and the promise. AU - Pickup,John C, AU - Hussain,Faeiza, AU - Evans,Nicholas D, AU - Sachedina,Nabihah, PY - 2004/06/30/received PY - 2004/08/06/revised PY - 2004/08/11/accepted PY - 2005/3/3/pubmed PY - 2005/8/16/medline PY - 2005/3/3/entrez SP - 1897 EP - 902 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 20 IS - 10 N2 - Glucose monitoring is an essential component of modern diabetes management. Three in vivo glucose sensors are now available for clinical use: a subcutaneously implanted amperometric enzyme electrode, a reverse iontophoresis system and a microdialysis-based device. Improvements in glucose-sensing technology continue to be sought, e.g. wired enzyme technology, viscometric affinity sensing and totally implanted glucose sensors. Non-invasive glucose sensing is the ultimate goal of glucose monitoring, but the most investigated approach, near-infrared (NIR) spectroscopy, is presently too imprecise for clinical application. Fluorescence-based glucose sensing offers several advantages and we are investigating strategies which include NIR-based fluorescence resonance energy transfer using concanavalin A/dextran; changes in the intrinsic fluorescence of hexokinase encapsulated in sol-gel; and non-invasive glucose monitoring of cells by measuring glucose-related changes in NADP(H). SN - 0956-5663 UR - https://www.unboundmedicine.com/medline/citation/15741056/In_vivo_glucose_monitoring:_the_clinical_reality_and_the_promise_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0956-5663(04)00384-7 DB - PRIME DP - Unbound Medicine ER -