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Human TSLP promotes CD40 ligand-induced IL-12 production by myeloid dendritic cells but maintains their Th2 priming potential.
Blood. 2005 Jun 15; 105(12):4749-51.Blood

Abstract

Interleukin-4 (IL-4), a major T-helper type 2 (Th2) cytokine, primes dendritic cells (DCs) for IL-12 production, suggesting a negative feedback loop to prevent dysregulated Th2 inflammation, such as allergy. We previously showed that human thymic stromal lymphopoietin (TSLP), highly expressed by keratinocytes of atopic dermatitis, activates CD11c(+) DCs to induce the differentiation of naive CD4(+) and CD8(+) T cells into proallergic effectors. Here we show that TSLP primes DCs to produce large amounts of IL-12 after CD40 ligand stimulation, similar to IL-4 priming of DCs. In contrast to IL-4 priming, DCs activated with TSLP and CD40 ligand induce the differentiation of naive CD4(+) T cells into effectors producing both Th1 and Th2 cytokines, a unique profile that is reminiscent of the late phase of allergy. Thus, TSLP is a major regulatory cytokine for IL-12 production by DCs, and TSLP-activated DCs could promote the persistence of Th2 inflammation even in the presence of IL-12-inducing signals.

Authors+Show Affiliations

DNAX Research Institute, Palo Alto, CA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15741223

Citation

Watanabe, Norihiko, et al. "Human TSLP Promotes CD40 Ligand-induced IL-12 Production By Myeloid Dendritic Cells but Maintains Their Th2 Priming Potential." Blood, vol. 105, no. 12, 2005, pp. 4749-51.
Watanabe N, Hanabuchi S, Marloie-Provost MA, et al. Human TSLP promotes CD40 ligand-induced IL-12 production by myeloid dendritic cells but maintains their Th2 priming potential. Blood. 2005;105(12):4749-51.
Watanabe, N., Hanabuchi, S., Marloie-Provost, M. A., Antonenko, S., Liu, Y. J., & Soumelis, V. (2005). Human TSLP promotes CD40 ligand-induced IL-12 production by myeloid dendritic cells but maintains their Th2 priming potential. Blood, 105(12), 4749-51.
Watanabe N, et al. Human TSLP Promotes CD40 Ligand-induced IL-12 Production By Myeloid Dendritic Cells but Maintains Their Th2 Priming Potential. Blood. 2005 Jun 15;105(12):4749-51. PubMed PMID: 15741223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human TSLP promotes CD40 ligand-induced IL-12 production by myeloid dendritic cells but maintains their Th2 priming potential. AU - Watanabe,Norihiko, AU - Hanabuchi,Shino, AU - Marloie-Provost,Marie-Annick, AU - Antonenko,Svetlana, AU - Liu,Yong-Jun, AU - Soumelis,Vassili, Y1 - 2005/03/01/ PY - 2005/3/3/pubmed PY - 2005/7/14/medline PY - 2005/3/3/entrez SP - 4749 EP - 51 JF - Blood JO - Blood VL - 105 IS - 12 N2 - Interleukin-4 (IL-4), a major T-helper type 2 (Th2) cytokine, primes dendritic cells (DCs) for IL-12 production, suggesting a negative feedback loop to prevent dysregulated Th2 inflammation, such as allergy. We previously showed that human thymic stromal lymphopoietin (TSLP), highly expressed by keratinocytes of atopic dermatitis, activates CD11c(+) DCs to induce the differentiation of naive CD4(+) and CD8(+) T cells into proallergic effectors. Here we show that TSLP primes DCs to produce large amounts of IL-12 after CD40 ligand stimulation, similar to IL-4 priming of DCs. In contrast to IL-4 priming, DCs activated with TSLP and CD40 ligand induce the differentiation of naive CD4(+) T cells into effectors producing both Th1 and Th2 cytokines, a unique profile that is reminiscent of the late phase of allergy. Thus, TSLP is a major regulatory cytokine for IL-12 production by DCs, and TSLP-activated DCs could promote the persistence of Th2 inflammation even in the presence of IL-12-inducing signals. SN - 0006-4971 UR - https://www.unboundmedicine.com/medline/citation/15741223/Human_TSLP_promotes_CD40_ligand_induced_IL_12_production_by_myeloid_dendritic_cells_but_maintains_their_Th2_priming_potential_ L2 - https://ashpublications.org/blood/article-lookup/doi/10.1182/blood-2004-09-3622 DB - PRIME DP - Unbound Medicine ER -