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Comparison of meglumine antimoniate and pentamidine for peruvian cutaneous leishmaniasis.
Am J Trop Med Hyg. 2005 Feb; 72(2):133-7.AJ

Abstract

Pentamidine was compared with meglumine antimoniate (Glucantime) for 80 patients with cutaneous leishmaniasis due to Leishmania braziliensis in Peru. Of the 40 patients administered Glucantime (20 mg of antimony [Sb]/kg/day intravenously for 20 days), 31 cured (78%), 6 failed (15%), of which 5 were due to relapse, and 3 were lost to follow-up (7%). Of the 40 patients administered pentamidine (2 mg/kg every other day for seven injections), 14 were cured (35%), 23 failed (58%), and 3 were lost to follow-up (7%). Five pentamidine failures were due to relapse, and 14 failures were due to the presence of parasites two weeks after therapy. Both regimens were well tolerated. Gastrointestinal, musculoskeletal, and total adverse events were not statistically different in either group. Elevations in levels of liver enzymes and pancreatic enzymes were statistically higher in the Glucantime group, but no patient terminated therapy prematurely. In this study, Glucantime was more effective than pentamidine for treatment of L. braziliensis cutaneous leishmaniasis in Peru based on parasitologic as well as clinical criteria.

Authors+Show Affiliations

Navy Environmental and Preventive Medicine Unit No. 5, San Diego, California 92136, USA. eandersen@nepmu5.med.navy.mil <eandersen@nepmu5.med.navy.mil>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

15741547

Citation

Andersen, Ellen M., et al. "Comparison of Meglumine Antimoniate and Pentamidine for Peruvian Cutaneous Leishmaniasis." The American Journal of Tropical Medicine and Hygiene, vol. 72, no. 2, 2005, pp. 133-7.
Andersen EM, Cruz-Saldarriaga M, Llanos-Cuentas A, et al. Comparison of meglumine antimoniate and pentamidine for peruvian cutaneous leishmaniasis. Am J Trop Med Hyg. 2005;72(2):133-7.
Andersen, E. M., Cruz-Saldarriaga, M., Llanos-Cuentas, A., Luz-Cjuno, M., Echevarria, J., Miranda-Verastegui, C., Colina, O., & Berman, J. D. (2005). Comparison of meglumine antimoniate and pentamidine for peruvian cutaneous leishmaniasis. The American Journal of Tropical Medicine and Hygiene, 72(2), 133-7.
Andersen EM, et al. Comparison of Meglumine Antimoniate and Pentamidine for Peruvian Cutaneous Leishmaniasis. Am J Trop Med Hyg. 2005;72(2):133-7. PubMed PMID: 15741547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of meglumine antimoniate and pentamidine for peruvian cutaneous leishmaniasis. AU - Andersen,Ellen M, AU - Cruz-Saldarriaga,Maria, AU - Llanos-Cuentas,Alejandro, AU - Luz-Cjuno,Maria, AU - Echevarria,Juan, AU - Miranda-Verastegui,Cesar, AU - Colina,Olga, AU - Berman,Jonathan D, PY - 2005/3/3/pubmed PY - 2005/4/9/medline PY - 2005/3/3/entrez SP - 133 EP - 7 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 72 IS - 2 N2 - Pentamidine was compared with meglumine antimoniate (Glucantime) for 80 patients with cutaneous leishmaniasis due to Leishmania braziliensis in Peru. Of the 40 patients administered Glucantime (20 mg of antimony [Sb]/kg/day intravenously for 20 days), 31 cured (78%), 6 failed (15%), of which 5 were due to relapse, and 3 were lost to follow-up (7%). Of the 40 patients administered pentamidine (2 mg/kg every other day for seven injections), 14 were cured (35%), 23 failed (58%), and 3 were lost to follow-up (7%). Five pentamidine failures were due to relapse, and 14 failures were due to the presence of parasites two weeks after therapy. Both regimens were well tolerated. Gastrointestinal, musculoskeletal, and total adverse events were not statistically different in either group. Elevations in levels of liver enzymes and pancreatic enzymes were statistically higher in the Glucantime group, but no patient terminated therapy prematurely. In this study, Glucantime was more effective than pentamidine for treatment of L. braziliensis cutaneous leishmaniasis in Peru based on parasitologic as well as clinical criteria. SN - 0002-9637 UR - https://www.unboundmedicine.com/medline/citation/15741547/Comparison_of_meglumine_antimoniate_and_pentamidine_for_peruvian_cutaneous_leishmaniasis_ L2 - https://ClinicalTrials.gov/search/term=15741547 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -