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Spectrum of neural-tube defects in 34 infants prenatally exposed to antiepileptic drugs.
Neurology 1992; 42(4 Suppl 5):111-8Neur

Abstract

We analyzed the spectrum of neural-tube defects associated with maternal exposure to antiepileptic drugs (AEDs) and the possible contribution of familial and genetic factors to epilepsy or neural-tube defects. No specific association with maternal family history of neural-tube defects or epilepsy was seen. The ratio of spina bifida to anencephaly (33:1) suggested a specific association with caudal defects. Hydrocephaly was documented in at least 21 cases. Other midline defects, all associated with valproate (VPA), were hypospadias (two), hypertelorism (two), partial agenesis of corpus callosum, agenesis of septum pellucidum with lissencephaly of medial sides of occipital lobes, Dandy-Walker anomaly, and ventricular septal defect. This study shows that most neural-tube defects following maternal VPA use are severe open defects. They are frequently complicated by hydrocephaly and other midline defects. Prenatal diagnosis is possible.

Authors+Show Affiliations

Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1574164

Citation

Lindhout, D, et al. "Spectrum of Neural-tube Defects in 34 Infants Prenatally Exposed to Antiepileptic Drugs." Neurology, vol. 42, no. 4 Suppl 5, 1992, pp. 111-8.
Lindhout D, Omtzigt JG, Cornel MC. Spectrum of neural-tube defects in 34 infants prenatally exposed to antiepileptic drugs. Neurology. 1992;42(4 Suppl 5):111-8.
Lindhout, D., Omtzigt, J. G., & Cornel, M. C. (1992). Spectrum of neural-tube defects in 34 infants prenatally exposed to antiepileptic drugs. Neurology, 42(4 Suppl 5), pp. 111-8.
Lindhout D, Omtzigt JG, Cornel MC. Spectrum of Neural-tube Defects in 34 Infants Prenatally Exposed to Antiepileptic Drugs. Neurology. 1992;42(4 Suppl 5):111-8. PubMed PMID: 1574164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spectrum of neural-tube defects in 34 infants prenatally exposed to antiepileptic drugs. AU - Lindhout,D, AU - Omtzigt,J G, AU - Cornel,M C, PY - 1992/4/1/pubmed PY - 1992/4/1/medline PY - 1992/4/1/entrez SP - 111 EP - 8 JF - Neurology JO - Neurology VL - 42 IS - 4 Suppl 5 N2 - We analyzed the spectrum of neural-tube defects associated with maternal exposure to antiepileptic drugs (AEDs) and the possible contribution of familial and genetic factors to epilepsy or neural-tube defects. No specific association with maternal family history of neural-tube defects or epilepsy was seen. The ratio of spina bifida to anencephaly (33:1) suggested a specific association with caudal defects. Hydrocephaly was documented in at least 21 cases. Other midline defects, all associated with valproate (VPA), were hypospadias (two), hypertelorism (two), partial agenesis of corpus callosum, agenesis of septum pellucidum with lissencephaly of medial sides of occipital lobes, Dandy-Walker anomaly, and ventricular septal defect. This study shows that most neural-tube defects following maternal VPA use are severe open defects. They are frequently complicated by hydrocephaly and other midline defects. Prenatal diagnosis is possible. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/1574164/Spectrum_of_neural_tube_defects_in_34_infants_prenatally_exposed_to_antiepileptic_drugs_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=1574164.ui DB - PRIME DP - Unbound Medicine ER -