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[Does folic acid have effects on other health problems than neural tube defects?].
Tidsskr Nor Laegeforen. 2005 Feb 17; 125(4):438-41.TN

Abstract

BACKGROUND

While it is widely accepted that periconceptional supplement of 400 microg (microgram) folic acid reduces the risk of neural tube defects in pregnancy, it remains to be established whether folic acid has other beneficial effects on larger population groups. Evidence concerning effect of increased intake on cardiovascular disease, cancer and other diseases has recently been evaluated in a report to the Directorate of Health and Social Welfare in Norway.

MATERIAL AND METHODS

Research reports published mainly from 1998 to 2003 on folic acid intake and disease have been evaluated.

RESULTS

Sufficient evidence that increased folic acid intake may prevent cancer or cardiovascular diseases is not yet available, hence at present there is no indication for recommending augmented intake for other groups than fertile women. However, several intervention studies with folic acid supplementation are in progress to establish its effect on cardiovascular mortality and morbidity.

INTERPRETATION

If the ongoing intervention studies show a beneficial clinical effect on cardiovascular disease, it would be a further argument for fortification of foods, in addition to reducing the risk of neural tube defects in pregnancy.

Authors+Show Affiliations

Kvinnesenteret, Kvinne-barn-divisjonen, Ullevål universitetssykehus, 0450 Oslo. annetine.staff@ulleval.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

nor

PubMed ID

15742017

Citation

Staff, Anne Cathrine, et al. "[Does Folic Acid Have Effects On Other Health Problems Than Neural Tube Defects?]." Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke, vol. 125, no. 4, 2005, pp. 438-41.
Staff AC, Holven K, Løken EB, et al. [Does folic acid have effects on other health problems than neural tube defects?]. Tidsskr Nor Laegeforen. 2005;125(4):438-41.
Staff, A. C., Holven, K., Løken, E. B., Sygnestveit, K., Vollset, S. E., & Smeland, S. (2005). [Does folic acid have effects on other health problems than neural tube defects?]. Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke, 125(4), 438-41.
Staff AC, et al. [Does Folic Acid Have Effects On Other Health Problems Than Neural Tube Defects?]. Tidsskr Nor Laegeforen. 2005 Feb 17;125(4):438-41. PubMed PMID: 15742017.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Does folic acid have effects on other health problems than neural tube defects?]. AU - Staff,Anne Cathrine, AU - Holven,Kirsten, AU - Løken,Elin Bjørge, AU - Sygnestveit,Kari, AU - Vollset,Stein Emil, AU - Smeland,Sigbjørn, PY - 2005/3/3/pubmed PY - 2005/3/8/medline PY - 2005/3/3/entrez SP - 438 EP - 41 JF - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke JO - Tidsskr. Nor. Laegeforen. VL - 125 IS - 4 N2 - BACKGROUND: While it is widely accepted that periconceptional supplement of 400 microg (microgram) folic acid reduces the risk of neural tube defects in pregnancy, it remains to be established whether folic acid has other beneficial effects on larger population groups. Evidence concerning effect of increased intake on cardiovascular disease, cancer and other diseases has recently been evaluated in a report to the Directorate of Health and Social Welfare in Norway. MATERIAL AND METHODS: Research reports published mainly from 1998 to 2003 on folic acid intake and disease have been evaluated. RESULTS: Sufficient evidence that increased folic acid intake may prevent cancer or cardiovascular diseases is not yet available, hence at present there is no indication for recommending augmented intake for other groups than fertile women. However, several intervention studies with folic acid supplementation are in progress to establish its effect on cardiovascular mortality and morbidity. INTERPRETATION: If the ongoing intervention studies show a beneficial clinical effect on cardiovascular disease, it would be a further argument for fortification of foods, in addition to reducing the risk of neural tube defects in pregnancy. SN - 0807-7096 UR - https://www.unboundmedicine.com/medline/citation/15742017/[Does_folic_acid_have_effects_on_other_health_problems_than_neural_tube_defects]_ L2 - http://tidsskriftet.no/article/1147030 DB - PRIME DP - Unbound Medicine ER -