Tags

Type your tag names separated by a space and hit enter

Caffeine effects on recovery sleep following 27 h total sleep deprivation.
Aviat Space Environ Med. 2005 Feb; 76(2):108-13.AS

Abstract

INTRODUCTION

Caffeine is widely used to reverse alertness and performance decrements. However, caffeine's effects on subsequent recovery sleep and post-recovery performance are not well documented and, therefore, were evaluated.

METHODS

Six habitually low (LC: < or = 100 mg x d(-1)) and three habitually high (HC: > or = 400 mg x d(-1)) caffeine users completed a randomized crossover design. After 20 h of wakefulness, repeated doses of caffeine gum [0 (placebo) mg, 100 (low dose) mg, or 300 (high dose) mg] were administered at 03:00, 05:00, and 07:00. At 10:00 (27 h sleep deprivation) subjects slept for 8 h, followed by Psychomotor Vigilance Task (PVT) administration at 33 and 65 min post-awakening.

RESULTS

Low dose caffeine increased stage 1 minutes only. However, high dose caffeine impaired sleep maintenance (reduced total sleep time/increased wake) and reduced sleep depth (increased stage 1 minutes/percentage and slow-wave sleep (SWS) latency, and reduced SWS minutes during the first third of the sleep period). With high dose caffeine, LC users had less SWS percentage as compared with HC users. The HC users had reduced stage 2 percentage with high dose caffeine as compared with placebo and low dose caffeine. Caffeine dose and habitual caffeine use did not influence post-recovery sleep PVT performance.

DISCUSSION

Caffeine exerts mild deleterious dose-response effects on recovery sleep following total sleep deprivation, primarily early in the sleep period, with potential recovery from these effects after sufficient sleep as suggested by lack of post-recovery sleep performance deficits. Habitual caffeine use appears to minimally reduce caffeine effects.

Authors+Show Affiliations

Department of Behavioral Biology, Division of Neurosciences, Walter Reed Army Institute of Research, Silver Spring, MD, USA. CML149@psu.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15742825

Citation

LaJambe, Cynthia M., et al. "Caffeine Effects On Recovery Sleep Following 27 H Total Sleep Deprivation." Aviation, Space, and Environmental Medicine, vol. 76, no. 2, 2005, pp. 108-13.
LaJambe CM, Kamimori GH, Belenky G, et al. Caffeine effects on recovery sleep following 27 h total sleep deprivation. Aviat Space Environ Med. 2005;76(2):108-13.
LaJambe, C. M., Kamimori, G. H., Belenky, G., & Balkin, T. J. (2005). Caffeine effects on recovery sleep following 27 h total sleep deprivation. Aviation, Space, and Environmental Medicine, 76(2), 108-13.
LaJambe CM, et al. Caffeine Effects On Recovery Sleep Following 27 H Total Sleep Deprivation. Aviat Space Environ Med. 2005;76(2):108-13. PubMed PMID: 15742825.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Caffeine effects on recovery sleep following 27 h total sleep deprivation. AU - LaJambe,Cynthia M, AU - Kamimori,Gary H, AU - Belenky,Gregory, AU - Balkin,Thomas J, PY - 2005/3/4/pubmed PY - 2005/6/2/medline PY - 2005/3/4/entrez SP - 108 EP - 13 JF - Aviation, space, and environmental medicine JO - Aviat Space Environ Med VL - 76 IS - 2 N2 - INTRODUCTION: Caffeine is widely used to reverse alertness and performance decrements. However, caffeine's effects on subsequent recovery sleep and post-recovery performance are not well documented and, therefore, were evaluated. METHODS: Six habitually low (LC: < or = 100 mg x d(-1)) and three habitually high (HC: > or = 400 mg x d(-1)) caffeine users completed a randomized crossover design. After 20 h of wakefulness, repeated doses of caffeine gum [0 (placebo) mg, 100 (low dose) mg, or 300 (high dose) mg] were administered at 03:00, 05:00, and 07:00. At 10:00 (27 h sleep deprivation) subjects slept for 8 h, followed by Psychomotor Vigilance Task (PVT) administration at 33 and 65 min post-awakening. RESULTS: Low dose caffeine increased stage 1 minutes only. However, high dose caffeine impaired sleep maintenance (reduced total sleep time/increased wake) and reduced sleep depth (increased stage 1 minutes/percentage and slow-wave sleep (SWS) latency, and reduced SWS minutes during the first third of the sleep period). With high dose caffeine, LC users had less SWS percentage as compared with HC users. The HC users had reduced stage 2 percentage with high dose caffeine as compared with placebo and low dose caffeine. Caffeine dose and habitual caffeine use did not influence post-recovery sleep PVT performance. DISCUSSION: Caffeine exerts mild deleterious dose-response effects on recovery sleep following total sleep deprivation, primarily early in the sleep period, with potential recovery from these effects after sufficient sleep as suggested by lack of post-recovery sleep performance deficits. Habitual caffeine use appears to minimally reduce caffeine effects. SN - 0095-6562 UR - https://www.unboundmedicine.com/medline/citation/15742825/Caffeine_effects_on_recovery_sleep_following_27_h_total_sleep_deprivation_ L2 - https://www.ingentaconnect.com/openurl?genre=article&amp;issn=0095-6562&amp;volume=76&amp;issue=2&amp;spage=108&amp;aulast=LaJambe DB - PRIME DP - Unbound Medicine ER -