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Periconceptional dietary intake of myo-inositol and neural tube defects in offspring.
Birth Defects Res A Clin Mol Teratol. 2005 Mar; 73(3):184-7.BD

Abstract

BACKGROUND

Periconceptional intake of nutrients in addition to folic acid may contribute to neural tube defect (NTD) etiologies; a likely candidate is myo-inositol. We investigated whether maternal periconceptional dietary intake of myo-inositol influenced NTD risk.

METHODS

Data were derived from a case-control study of fetuses and infants with NTDs among 1989-1991 California births. Interviews were conducted with mothers of 454 NTD cases and with mothers of 462 nonmalformed controls. A standard 100-item food frequency questionnaire was used to assess nutrient intake.

RESULTS

We observed small increases in risk, with increases slightly more evident for anencephaly, associated with intakes of myo-inositol less than the highest intake quartile, e.g., risk of anencephaly was 1.3 (0.7-2.4) among fetuses whose mothers consumed lowest versus highest intakes of myo-inositol. These small increases, however, were imprecise, and also did not indicate increasing risk with decreasing level of myo-inositol intake. Adjusted risk estimates did not differ considerably from their unadjusted counterparts.

CONCLUSIONS

Our results do not indicate that myo-inositol intake, as measured in this study, is strongly associated with risk of human NTDs.

Authors+Show Affiliations

March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, 1917 Fifth St., Berkeley, CA 94710, USA. gsh@cbdmp.orgNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15744734

Citation

Shaw, Gary M., et al. "Periconceptional Dietary Intake of Myo-inositol and Neural Tube Defects in Offspring." Birth Defects Research. Part A, Clinical and Molecular Teratology, vol. 73, no. 3, 2005, pp. 184-7.
Shaw GM, Carmichael SL, Yang W, et al. Periconceptional dietary intake of myo-inositol and neural tube defects in offspring. Birth Defects Res A Clin Mol Teratol. 2005;73(3):184-7.
Shaw, G. M., Carmichael, S. L., Yang, W., & Schaffer, D. M. (2005). Periconceptional dietary intake of myo-inositol and neural tube defects in offspring. Birth Defects Research. Part A, Clinical and Molecular Teratology, 73(3), 184-7.
Shaw GM, et al. Periconceptional Dietary Intake of Myo-inositol and Neural Tube Defects in Offspring. Birth Defects Res A Clin Mol Teratol. 2005;73(3):184-7. PubMed PMID: 15744734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Periconceptional dietary intake of myo-inositol and neural tube defects in offspring. AU - Shaw,Gary M, AU - Carmichael,Suzan L, AU - Yang,Wei, AU - Schaffer,Donna M, PY - 2005/3/4/pubmed PY - 2005/8/24/medline PY - 2005/3/4/entrez SP - 184 EP - 7 JF - Birth defects research. Part A, Clinical and molecular teratology JO - Birth Defects Res A Clin Mol Teratol VL - 73 IS - 3 N2 - BACKGROUND: Periconceptional intake of nutrients in addition to folic acid may contribute to neural tube defect (NTD) etiologies; a likely candidate is myo-inositol. We investigated whether maternal periconceptional dietary intake of myo-inositol influenced NTD risk. METHODS: Data were derived from a case-control study of fetuses and infants with NTDs among 1989-1991 California births. Interviews were conducted with mothers of 454 NTD cases and with mothers of 462 nonmalformed controls. A standard 100-item food frequency questionnaire was used to assess nutrient intake. RESULTS: We observed small increases in risk, with increases slightly more evident for anencephaly, associated with intakes of myo-inositol less than the highest intake quartile, e.g., risk of anencephaly was 1.3 (0.7-2.4) among fetuses whose mothers consumed lowest versus highest intakes of myo-inositol. These small increases, however, were imprecise, and also did not indicate increasing risk with decreasing level of myo-inositol intake. Adjusted risk estimates did not differ considerably from their unadjusted counterparts. CONCLUSIONS: Our results do not indicate that myo-inositol intake, as measured in this study, is strongly associated with risk of human NTDs. SN - 1542-0752 UR - https://www.unboundmedicine.com/medline/citation/15744734/Periconceptional_dietary_intake_of_myo_inositol_and_neural_tube_defects_in_offspring_ DB - PRIME DP - Unbound Medicine ER -