Tags

Type your tag names separated by a space and hit enter

Plasma adiponectin and insulin resistance in Korean type 2 diabetes mellitus.
Yonsei Med J 2005; 46(1):42-50YM

Abstract

Insulin resistance, which implies impairment of insulin signaling in the target tissues, is a common cause of type 2 diabetes. Adipose tissue plays an important role in insulin resistance through the dysregulated production and secretion of adipose-derived proteins, including tumor necrosis factor-alpha, plasminogen activator inhibitor-1, leptin, resistin, angiotensinogen, and adiponectin. Adiponectin was estimated to be a protective adipocytokine against atherosclerosis, and also to have an anti-inflammatory effect. In this study, the relationship between fasting plasma adiponectin concentration and adiposity, body composition, insulin sensitivity (ITT, HOMAIR, QUICK), lipid profile, fasting insulin concentration were examined in Korean type 2 diabetes. The difference in the adiponectin concentrations was also examined in diabetic and non-diabetic subjects, with adjustment for gender, age and body mass index. 102 type 2 diabetics and 50 controls were examined. After a 12-h overnight fast, all subjects underwent a 75 gram oral glucose tolerance test. Baseline blood samples were drawn for the determinations of fasting plasma glucose, insulin, adiponectin, total cholesterol, triglyceride, LDL-cholesterol, and HDL-cholesterol. The body composition was estimated using a bioelectric impedance analyzer (Inbody 2.0). The insulin sensitivity was estimated using the insulin tolerance test (ITT), HOMAIR and QUICK methods. In the diabetic group, the fasting adiponectin concentrations were significantly lower in men than in women. They were negatively correlated with BMI (r=-0.453), hip circumference (r=-0.341), fasting glucose concentrations (r=-0.277) and HOMAIR (r= -0.233). In addition, they were positively correlated with systolic blood pressure (r=0.321) and HDL-cholesterol (r= 0.291). The systolic blood pressure and HDL-cholesterol were found to be independent variables, from a multiple logistic regression analysis, which influenced the adiponectin concentration. Compared with the non-diabetic group, the adiponectin concentrations were significantly lower in the diabetic group, with the exception of obese males. In conclusion, the plasma adiponectin concentrations were closely related to the insulin resistance parameters in Korean type 2 diabetic patients.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Konkuk University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15744804

Citation

Kim, Mi-Jin, et al. "Plasma Adiponectin and Insulin Resistance in Korean Type 2 Diabetes Mellitus." Yonsei Medical Journal, vol. 46, no. 1, 2005, pp. 42-50.
Kim MJ, Yoo KH, Park HS, et al. Plasma adiponectin and insulin resistance in Korean type 2 diabetes mellitus. Yonsei Med J. 2005;46(1):42-50.
Kim, M. J., Yoo, K. H., Park, H. S., Chung, S. M., Jin, C. J., Lee, Y., ... Chung, C. H. (2005). Plasma adiponectin and insulin resistance in Korean type 2 diabetes mellitus. Yonsei Medical Journal, 46(1), pp. 42-50.
Kim MJ, et al. Plasma Adiponectin and Insulin Resistance in Korean Type 2 Diabetes Mellitus. Yonsei Med J. 2005 Feb 28;46(1):42-50. PubMed PMID: 15744804.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma adiponectin and insulin resistance in Korean type 2 diabetes mellitus. AU - Kim,Mi-Jin, AU - Yoo,Kwang-Ha, AU - Park,Hyung-Suk, AU - Chung,Sang-Man, AU - Jin,Choon-Jo, AU - Lee,Yoen, AU - Shin,Young-Goo, AU - Chung,Choon-Hee, PY - 2005/3/4/pubmed PY - 2005/4/29/medline PY - 2005/3/4/entrez SP - 42 EP - 50 JF - Yonsei medical journal JO - Yonsei Med. J. VL - 46 IS - 1 N2 - Insulin resistance, which implies impairment of insulin signaling in the target tissues, is a common cause of type 2 diabetes. Adipose tissue plays an important role in insulin resistance through the dysregulated production and secretion of adipose-derived proteins, including tumor necrosis factor-alpha, plasminogen activator inhibitor-1, leptin, resistin, angiotensinogen, and adiponectin. Adiponectin was estimated to be a protective adipocytokine against atherosclerosis, and also to have an anti-inflammatory effect. In this study, the relationship between fasting plasma adiponectin concentration and adiposity, body composition, insulin sensitivity (ITT, HOMAIR, QUICK), lipid profile, fasting insulin concentration were examined in Korean type 2 diabetes. The difference in the adiponectin concentrations was also examined in diabetic and non-diabetic subjects, with adjustment for gender, age and body mass index. 102 type 2 diabetics and 50 controls were examined. After a 12-h overnight fast, all subjects underwent a 75 gram oral glucose tolerance test. Baseline blood samples were drawn for the determinations of fasting plasma glucose, insulin, adiponectin, total cholesterol, triglyceride, LDL-cholesterol, and HDL-cholesterol. The body composition was estimated using a bioelectric impedance analyzer (Inbody 2.0). The insulin sensitivity was estimated using the insulin tolerance test (ITT), HOMAIR and QUICK methods. In the diabetic group, the fasting adiponectin concentrations were significantly lower in men than in women. They were negatively correlated with BMI (r=-0.453), hip circumference (r=-0.341), fasting glucose concentrations (r=-0.277) and HOMAIR (r= -0.233). In addition, they were positively correlated with systolic blood pressure (r=0.321) and HDL-cholesterol (r= 0.291). The systolic blood pressure and HDL-cholesterol were found to be independent variables, from a multiple logistic regression analysis, which influenced the adiponectin concentration. Compared with the non-diabetic group, the adiponectin concentrations were significantly lower in the diabetic group, with the exception of obese males. In conclusion, the plasma adiponectin concentrations were closely related to the insulin resistance parameters in Korean type 2 diabetic patients. SN - 0513-5796 UR - https://www.unboundmedicine.com/medline/citation/15744804/Plasma_adiponectin_and_insulin_resistance_in_Korean_type_2_diabetes_mellitus_ L2 - https://www.eymj.org/DOIx.php?id=10.3349/ymj.2005.46.1.42 DB - PRIME DP - Unbound Medicine ER -