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Pathogenicity of H5 influenza viruses for ducks.
Arch Virol 2005; 150(7):1383-92AV

Abstract

Four H5N1 highly pathogenic avian influenza (HPAI) viruses and an avirulent reassortant H5N1 virus were tested for their pathogenicity in domestic ducks. A/chicken/Yamaguchi/7/04 (H5N1) (Ck/Yamaguchi/04) isolated from a dead bird during the HPAI outbreak in Japan and A/duck/Yokohama/aq-10/03 (H5N1) (Dk/Yokohama/03) isolated from duck meat at a quarantine inspection for importation from China replicated in multiple organs including the brain of ducks. The ducks infected with Ck/Yamaguchi/04 did not show any clinical signs, while those infected with Dk/Yokohama/03 showed neurological signs. The ducks infected either with A/Hong Kong/483/97 (H5N1) or A/tern/South Africa/61 (H5N3), or with an avirulent H5N1 reassortant, did not show any clinical signs. Virus-specific antibodies were detected in the sera of the ducks infected with each of the five strains tested, indicating that all of the viral strains infected and replicated in the birds. Dk/Yokohama/03 grew in multiple organs more rapidly than did Ck/Yamaguchi/04. Considerable titers of virus were detected in the brain of the ducks infected with Dk/Yokohama/03 and these birds showed neurological signs. The present results demonstrate that the pathogenicity of influenza viruses for ducks does not correlate with that for chickens and that replication of the virus in the brain is critical for ducks to show neurological signs.

Authors+Show Affiliations

Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15747052

Citation

Kishida, N, et al. "Pathogenicity of H5 Influenza Viruses for Ducks." Archives of Virology, vol. 150, no. 7, 2005, pp. 1383-92.
Kishida N, Sakoda Y, Isoda N, et al. Pathogenicity of H5 influenza viruses for ducks. Arch Virol. 2005;150(7):1383-92.
Kishida, N., Sakoda, Y., Isoda, N., Matsuda, K., Eto, M., Sunaga, Y., ... Kida, H. (2005). Pathogenicity of H5 influenza viruses for ducks. Archives of Virology, 150(7), pp. 1383-92.
Kishida N, et al. Pathogenicity of H5 Influenza Viruses for Ducks. Arch Virol. 2005;150(7):1383-92. PubMed PMID: 15747052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathogenicity of H5 influenza viruses for ducks. AU - Kishida,N, AU - Sakoda,Y, AU - Isoda,N, AU - Matsuda,K, AU - Eto,M, AU - Sunaga,Y, AU - Umemura,T, AU - Kida,H, Y1 - 2005/03/03/ PY - 2004/10/12/received PY - 2004/11/22/accepted PY - 2005/3/5/pubmed PY - 2005/10/12/medline PY - 2005/3/5/entrez SP - 1383 EP - 92 JF - Archives of virology JO - Arch. Virol. VL - 150 IS - 7 N2 - Four H5N1 highly pathogenic avian influenza (HPAI) viruses and an avirulent reassortant H5N1 virus were tested for their pathogenicity in domestic ducks. A/chicken/Yamaguchi/7/04 (H5N1) (Ck/Yamaguchi/04) isolated from a dead bird during the HPAI outbreak in Japan and A/duck/Yokohama/aq-10/03 (H5N1) (Dk/Yokohama/03) isolated from duck meat at a quarantine inspection for importation from China replicated in multiple organs including the brain of ducks. The ducks infected with Ck/Yamaguchi/04 did not show any clinical signs, while those infected with Dk/Yokohama/03 showed neurological signs. The ducks infected either with A/Hong Kong/483/97 (H5N1) or A/tern/South Africa/61 (H5N3), or with an avirulent H5N1 reassortant, did not show any clinical signs. Virus-specific antibodies were detected in the sera of the ducks infected with each of the five strains tested, indicating that all of the viral strains infected and replicated in the birds. Dk/Yokohama/03 grew in multiple organs more rapidly than did Ck/Yamaguchi/04. Considerable titers of virus were detected in the brain of the ducks infected with Dk/Yokohama/03 and these birds showed neurological signs. The present results demonstrate that the pathogenicity of influenza viruses for ducks does not correlate with that for chickens and that replication of the virus in the brain is critical for ducks to show neurological signs. SN - 0304-8608 UR - https://www.unboundmedicine.com/medline/citation/15747052/Pathogenicity_of_H5_influenza_viruses_for_ducks_ L2 - https://dx.doi.org/10.1007/s00705-004-0473-x DB - PRIME DP - Unbound Medicine ER -