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Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European Prospective Cohort on Thrombophilia (EPCOT).
J Thromb Haemost 2005; 3(3):459-64JT

Abstract

BACKGROUND

Reliable risk estimates for venous thrombosis in families with inherited thrombophilia are scarce but necessary for determining optimal screening and treatment policies.

OBJECTIVES

In the present analysis, we determined the risk of a first venous thrombotic event in carriers of a thrombophilic defect (i.e. antithrombin-, protein C- or protein S deficiency, or factor V Leiden).

PATIENTS AND METHODS

The asymptomatic carriers had been tested prior to this study in nine European thrombosis centers because of a symptomatic carrier in the family, and were followed prospectively for 5.7 years on average between March 1994 and January 2001. Annually, data were recorded on the occurrence of risk situations for venous thrombosis and events (e.g. venous thrombosis, death).

RESULTS

Twenty-six of the 575 asymptomatic carriers (4.5%) and seven of the 1118 controls (0.6%) experienced a first deep venous thrombosis or pulmonary embolism during follow-up. Of these events, 58% occurred spontaneously in the carriers compared with 43% in the controls. The incidence of first events was 0.8% per year (95% CI 0.5-1.2) in the carriers compared with 0.1% per year (95% CI 0.0-0.2) in the controls. The highest incidence was associated with antithrombin deficiency or combined defects, and the lowest incidence with factor V Leiden.

CONCLUSIONS

The incidence of venous events in asymptomatic individuals from thrombophilic families does not exceed the risk of bleeding associated with long-term anticoagulant treatment in the literature (1-3%).

Authors+Show Affiliations

Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15748234

Citation

Vossen, C Y., et al. "Risk of a First Venous Thrombotic Event in Carriers of a Familial Thrombophilic Defect. the European Prospective Cohort On Thrombophilia (EPCOT)." Journal of Thrombosis and Haemostasis : JTH, vol. 3, no. 3, 2005, pp. 459-64.
Vossen CY, Conard J, Fontcuberta J, et al. Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European Prospective Cohort on Thrombophilia (EPCOT). J Thromb Haemost. 2005;3(3):459-64.
Vossen, C. Y., Conard, J., Fontcuberta, J., Makris, M., VAN DER Meer, F. J., Pabinger, I., ... Rosendaal, F. R. (2005). Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European Prospective Cohort on Thrombophilia (EPCOT). Journal of Thrombosis and Haemostasis : JTH, 3(3), pp. 459-64.
Vossen CY, et al. Risk of a First Venous Thrombotic Event in Carriers of a Familial Thrombophilic Defect. the European Prospective Cohort On Thrombophilia (EPCOT). J Thromb Haemost. 2005;3(3):459-64. PubMed PMID: 15748234.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European Prospective Cohort on Thrombophilia (EPCOT). AU - Vossen,C Y, AU - Conard,J, AU - Fontcuberta,J, AU - Makris,M, AU - VAN DER Meer,F J M, AU - Pabinger,I, AU - Palareti,G, AU - Preston,F E, AU - Scharrer,I, AU - Souto,J C, AU - Svensson,P, AU - Walker,I D, AU - Rosendaal,F R, PY - 2005/3/8/pubmed PY - 2005/9/1/medline PY - 2005/3/8/entrez SP - 459 EP - 64 JF - Journal of thrombosis and haemostasis : JTH JO - J. Thromb. Haemost. VL - 3 IS - 3 N2 - BACKGROUND: Reliable risk estimates for venous thrombosis in families with inherited thrombophilia are scarce but necessary for determining optimal screening and treatment policies. OBJECTIVES: In the present analysis, we determined the risk of a first venous thrombotic event in carriers of a thrombophilic defect (i.e. antithrombin-, protein C- or protein S deficiency, or factor V Leiden). PATIENTS AND METHODS: The asymptomatic carriers had been tested prior to this study in nine European thrombosis centers because of a symptomatic carrier in the family, and were followed prospectively for 5.7 years on average between March 1994 and January 2001. Annually, data were recorded on the occurrence of risk situations for venous thrombosis and events (e.g. venous thrombosis, death). RESULTS: Twenty-six of the 575 asymptomatic carriers (4.5%) and seven of the 1118 controls (0.6%) experienced a first deep venous thrombosis or pulmonary embolism during follow-up. Of these events, 58% occurred spontaneously in the carriers compared with 43% in the controls. The incidence of first events was 0.8% per year (95% CI 0.5-1.2) in the carriers compared with 0.1% per year (95% CI 0.0-0.2) in the controls. The highest incidence was associated with antithrombin deficiency or combined defects, and the lowest incidence with factor V Leiden. CONCLUSIONS: The incidence of venous events in asymptomatic individuals from thrombophilic families does not exceed the risk of bleeding associated with long-term anticoagulant treatment in the literature (1-3%). SN - 1538-7933 UR - https://www.unboundmedicine.com/medline/citation/15748234/Risk_of_a_first_venous_thrombotic_event_in_carriers_of_a_familial_thrombophilic_defect__The_European_Prospective_Cohort_on_Thrombophilia__EPCOT__ L2 - https://doi.org/10.1111/j.1538-7836.2005.01197.x DB - PRIME DP - Unbound Medicine ER -