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Place cells of aged rats in two visually identical compartments.
Neurobiol Aging. 2005 Jul; 26(7):1099-106.NA

Abstract

Aged rats perform poorly on spatial learning tasks, a cognitive impairment which has been linked to the failure of hippocampal networks to fully encode changes in the external environment [Barnes CA, Suster MS, Shen J, McNaughton BL. Multistability of cognitive maps in the hippocampus of old rats. Nature 1997;388(6639):272-5; Wilson IA, Ikonen S, Gureviciene I, McMahan RW, Gallagher M, Eichenbaum H, et al. Cognitive aging and the hippocampus: how old rats represent new environments. J Neurosci 2004;24(15):3870-8]. To examine whether the impairment in hippocampal processing extends to conditions in which self-motion provides the cues for environmental change, we have analyzed spatial firing patterns of hippocampal pyramidal neurons in young and aged rats, as well as in young rats with selective cholinergic lesions, another model of cognitive aging. The rats walked between two visually identical environments, pitting self-motion cues that indicated environmental change against visual inputs that indicated no differences between environments. Our results indicated that place cells in both aged and cholinergic-lesioned rats were equally likely as those of young rats to create new spatial representations in the second compartment. These findings suggest that the hippocampal network of aged rats is able to process changes in internally generated cues without rigidity, but that incomplete processing of external landmark cues may lead to impaired spatial learning.

Authors+Show Affiliations

Department of Neuroscience and Neurology, University of Kuopio, P.O. Box 1627 (Harjulantie 1), Kuopio 70211, Finland. Iain.Wilson@uku.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15748790

Citation

Wilson, Iain A., et al. "Place Cells of Aged Rats in Two Visually Identical Compartments." Neurobiology of Aging, vol. 26, no. 7, 2005, pp. 1099-106.
Wilson IA, Ikonen S, Gurevicius K, et al. Place cells of aged rats in two visually identical compartments. Neurobiol Aging. 2005;26(7):1099-106.
Wilson, I. A., Ikonen, S., Gurevicius, K., McMahan, R. W., Gallagher, M., Eichenbaum, H., & Tanila, H. (2005). Place cells of aged rats in two visually identical compartments. Neurobiology of Aging, 26(7), 1099-106.
Wilson IA, et al. Place Cells of Aged Rats in Two Visually Identical Compartments. Neurobiol Aging. 2005;26(7):1099-106. PubMed PMID: 15748790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Place cells of aged rats in two visually identical compartments. AU - Wilson,Iain A, AU - Ikonen,Sami, AU - Gurevicius,Kestutis, AU - McMahan,Robert W, AU - Gallagher,Michela, AU - Eichenbaum,Howard, AU - Tanila,Heikki, Y1 - 2004/11/21/ PY - 2004/04/26/received PY - 2004/08/11/revised PY - 2004/09/15/accepted PY - 2005/3/8/pubmed PY - 2005/5/21/medline PY - 2005/3/8/entrez SP - 1099 EP - 106 JF - Neurobiology of aging JO - Neurobiol Aging VL - 26 IS - 7 N2 - Aged rats perform poorly on spatial learning tasks, a cognitive impairment which has been linked to the failure of hippocampal networks to fully encode changes in the external environment [Barnes CA, Suster MS, Shen J, McNaughton BL. Multistability of cognitive maps in the hippocampus of old rats. Nature 1997;388(6639):272-5; Wilson IA, Ikonen S, Gureviciene I, McMahan RW, Gallagher M, Eichenbaum H, et al. Cognitive aging and the hippocampus: how old rats represent new environments. J Neurosci 2004;24(15):3870-8]. To examine whether the impairment in hippocampal processing extends to conditions in which self-motion provides the cues for environmental change, we have analyzed spatial firing patterns of hippocampal pyramidal neurons in young and aged rats, as well as in young rats with selective cholinergic lesions, another model of cognitive aging. The rats walked between two visually identical environments, pitting self-motion cues that indicated environmental change against visual inputs that indicated no differences between environments. Our results indicated that place cells in both aged and cholinergic-lesioned rats were equally likely as those of young rats to create new spatial representations in the second compartment. These findings suggest that the hippocampal network of aged rats is able to process changes in internally generated cues without rigidity, but that incomplete processing of external landmark cues may lead to impaired spatial learning. SN - 0197-4580 UR - https://www.unboundmedicine.com/medline/citation/15748790/Place_cells_of_aged_rats_in_two_visually_identical_compartments_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(04)00305-7 DB - PRIME DP - Unbound Medicine ER -