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A study of lipoprotein lipase gene intron 8 polymorphisms in Chinese Han race essential hypertension patients.
Int J Cardiol. 2005 Mar 18; 99(2):263-7.IJ

Abstract

OBJECTIVE

To investigate the association of lipoprotein lipase gene intron 8 polymorphisms and Essential Hypertension in Han race Chinese.

METHODS AND RESULTS

116 patients with Essential Hypertension were enrolled and another 116 normal people were served as controls. All cases were examined for the genotypes of intron 8 in lipoprotein lipase gene by the methods of polymerase chain reaction restriction fragment length polymorphism, and the serum lipoprotein levels were also observed. Results showed that body mass index blood pressure and the serum triglyceride level were obviously increased in the Essential Hypertension group. The genotype and allele frequency of intron 8 in lipoprotein lipase in the Essential Hypertension group showed obvious differences compared with the control group. Serum triglyceride levels were higher in the patients with H+H+ genotype than in those in non H+H+ genotype of intron 8 in lipoprotein lipase by HindIII digestion. The systolic blood pressure showed a decreasing tendency among the H+H+ genotype, the H+H- genotype and the H-H- genotype individuals.

CONCLUSION

The results suggest that lipoprotein lipase may be an important genetic factor associated with the Chinese Han race Essential Hypertension patients. The polymorphisms of intron 8 in lipoprotein lipase influence the blood-lipid metabolism, induce blood vessel rebuilding and play an important role in the invasion and development of Essential Hypertension.

Authors+Show Affiliations

Department of Internal Medicine and Cardiology, Renmin Hospital of Wuhan University, Wuhan 430061, PR China. partner@public.wh.hb.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15749185

Citation

Tu, Xin, et al. "A Study of Lipoprotein Lipase Gene Intron 8 Polymorphisms in Chinese Han Race Essential Hypertension Patients." International Journal of Cardiology, vol. 99, no. 2, 2005, pp. 263-7.
Tu X, Tu J, Wen X, et al. A study of lipoprotein lipase gene intron 8 polymorphisms in Chinese Han race essential hypertension patients. Int J Cardiol. 2005;99(2):263-7.
Tu, X., Tu, J., Wen, X., Wang, J., & Zhang, D. (2005). A study of lipoprotein lipase gene intron 8 polymorphisms in Chinese Han race essential hypertension patients. International Journal of Cardiology, 99(2), 263-7.
Tu X, et al. A Study of Lipoprotein Lipase Gene Intron 8 Polymorphisms in Chinese Han Race Essential Hypertension Patients. Int J Cardiol. 2005 Mar 18;99(2):263-7. PubMed PMID: 15749185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A study of lipoprotein lipase gene intron 8 polymorphisms in Chinese Han race essential hypertension patients. AU - Tu,Xin, AU - Tu,Jinwen, AU - Wen,Xiuying, AU - Wang,Jinming, AU - Zhang,Daoliang, PY - 2003/09/20/received PY - 2004/01/04/revised PY - 2004/01/08/accepted PY - 2005/3/8/pubmed PY - 2005/6/17/medline PY - 2005/3/8/entrez SP - 263 EP - 7 JF - International journal of cardiology JO - Int J Cardiol VL - 99 IS - 2 N2 - OBJECTIVE: To investigate the association of lipoprotein lipase gene intron 8 polymorphisms and Essential Hypertension in Han race Chinese. METHODS AND RESULTS: 116 patients with Essential Hypertension were enrolled and another 116 normal people were served as controls. All cases were examined for the genotypes of intron 8 in lipoprotein lipase gene by the methods of polymerase chain reaction restriction fragment length polymorphism, and the serum lipoprotein levels were also observed. Results showed that body mass index blood pressure and the serum triglyceride level were obviously increased in the Essential Hypertension group. The genotype and allele frequency of intron 8 in lipoprotein lipase in the Essential Hypertension group showed obvious differences compared with the control group. Serum triglyceride levels were higher in the patients with H+H+ genotype than in those in non H+H+ genotype of intron 8 in lipoprotein lipase by HindIII digestion. The systolic blood pressure showed a decreasing tendency among the H+H+ genotype, the H+H- genotype and the H-H- genotype individuals. CONCLUSION: The results suggest that lipoprotein lipase may be an important genetic factor associated with the Chinese Han race Essential Hypertension patients. The polymorphisms of intron 8 in lipoprotein lipase influence the blood-lipid metabolism, induce blood vessel rebuilding and play an important role in the invasion and development of Essential Hypertension. SN - 0167-5273 UR - https://www.unboundmedicine.com/medline/citation/15749185/A_study_of_lipoprotein_lipase_gene_intron_8_polymorphisms_in_Chinese_Han_race_essential_hypertension_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S016752730400213X DB - PRIME DP - Unbound Medicine ER -