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The macular xanthophylls.
Surv Ophthalmol. 2005 Mar-Apr; 50(2):183-93.SO

Abstract

The macular pigments are predominantly composed of three carotenoids: lutein, zeaxanthin, and meso-zeaxanthin. These carotenoids are concentrated and distributed in a selective manner. The properties of these pigments are further explored along with their methods of uptake, stabilization, and storage. The dual nature of these pigments as filters and antioxidants are elaborated upon in relation to their protective effects upon the macula, specifically in age-related macular degeneration. Evidence suggests that increased levels of macular pigment are correlated with a decreased risk of age-related macular degeneration. Many have sought to exploit this therapeutic relation. Studies reveal that oral supplementation with lutein and zeaxanthin can increase the levels of macular pigments in the retina and plasma. The effects of such supplementation on actual ocular function have yet to be fully addressed. New and standardized methods of assessing macular pigment density are discussed and future areas of research to further our understanding of macular xanthophylls as they pertain to age-related macular degeneration are highlighted.

Authors+Show Affiliations

Department of Ophthalmology, Medical College of Georgia, Augusta, Georgia 30912-3400, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15749308

Citation

Ahmed, Shazia S., et al. "The Macular Xanthophylls." Survey of Ophthalmology, vol. 50, no. 2, 2005, pp. 183-93.
Ahmed SS, Lott MN, Marcus DM. The macular xanthophylls. Surv Ophthalmol. 2005;50(2):183-93.
Ahmed, S. S., Lott, M. N., & Marcus, D. M. (2005). The macular xanthophylls. Survey of Ophthalmology, 50(2), 183-93.
Ahmed SS, Lott MN, Marcus DM. The Macular Xanthophylls. Surv Ophthalmol. 2005 Mar-Apr;50(2):183-93. PubMed PMID: 15749308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The macular xanthophylls. AU - Ahmed,Shazia S, AU - Lott,McGregor N, AU - Marcus,Dennis M, PY - 2005/3/8/pubmed PY - 2005/4/20/medline PY - 2005/3/8/entrez SP - 183 EP - 93 JF - Survey of ophthalmology JO - Surv Ophthalmol VL - 50 IS - 2 N2 - The macular pigments are predominantly composed of three carotenoids: lutein, zeaxanthin, and meso-zeaxanthin. These carotenoids are concentrated and distributed in a selective manner. The properties of these pigments are further explored along with their methods of uptake, stabilization, and storage. The dual nature of these pigments as filters and antioxidants are elaborated upon in relation to their protective effects upon the macula, specifically in age-related macular degeneration. Evidence suggests that increased levels of macular pigment are correlated with a decreased risk of age-related macular degeneration. Many have sought to exploit this therapeutic relation. Studies reveal that oral supplementation with lutein and zeaxanthin can increase the levels of macular pigments in the retina and plasma. The effects of such supplementation on actual ocular function have yet to be fully addressed. New and standardized methods of assessing macular pigment density are discussed and future areas of research to further our understanding of macular xanthophylls as they pertain to age-related macular degeneration are highlighted. SN - 0039-6257 UR - https://www.unboundmedicine.com/medline/citation/15749308/The_macular_xanthophylls_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-6257(04)00189-4 DB - PRIME DP - Unbound Medicine ER -