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The homeopathic preparation Vertigoheel versus Ginkgo biloba in the treatment of vertigo in an elderly population: a double-blinded, randomized, controlled clinical trial.
J Altern Complement Med 2005; 11(1):155-60JA

Abstract

OBJECTIVE

Alternative medical practices are common in the treatment of vertigo. This study compared the effects of Ginkgo biloba treatment with the homeopathic remedy Vertigoheel (Biologische Heilmittel Heel GmbH, Baden-Baden, Germany).

DESIGN

Randomized, double-blinded, parallel group study.

SUBJECTS

One hundred and seventy (170) patients, ages 60-80 years, with atherosclerosis-related vertigo.

INTERVENTIONS

Patients were randomly allocated to receive treatment with either Vertigoheel (n = 87) or G. biloba (n = 83).

OUTCOME MEASURES

The results were analyzed for the non-inferiority of Vertigoheel to G. biloba on the combined endpoint of changes from baseline to week 6 in dizziness score (assessed by questionnaire), frequency, duration, and intensity of vertigo episodes (recorded in patient diaries).

RESULTS

Both treatments improved vertigo status. From a baseline mean value of 26.1 +/- 5.2 (on a 50-point scale) in the Vertigoheel group, the dizziness questionnaire score improved by -10.6 +/- 10.0, and by -10.7 +/- 9.0 from 25.8 - 4.7 in the G. biloba group. Statistical analysis of this endpoint showed that Vertigoheel was not inferior to G. biloba. The 95% confidence interval for the difference between treatment did not reach the inferiority threshold of 0.36 at any of the time points tested. The results were supported by the results of a line walking test, Unterberger's stepping test, and patient and physician global assessments of therapeutic effect. Both treatments were well tolerated.

CONCLUSIONS

Vertigoheel is an appealing alternative to established G. biloba therapy for atherosclerosis-related vertigo.

Authors+Show Affiliations

The Freeman Hospital, Newcastle upon Tyne, United Kingdom.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15750375

Citation

Issing, Wolfgang, et al. "The Homeopathic Preparation Vertigoheel Versus Ginkgo Biloba in the Treatment of Vertigo in an Elderly Population: a Double-blinded, Randomized, Controlled Clinical Trial." Journal of Alternative and Complementary Medicine (New York, N.Y.), vol. 11, no. 1, 2005, pp. 155-60.
Issing W, Klein P, Weiser M. The homeopathic preparation Vertigoheel versus Ginkgo biloba in the treatment of vertigo in an elderly population: a double-blinded, randomized, controlled clinical trial. J Altern Complement Med. 2005;11(1):155-60.
Issing, W., Klein, P., & Weiser, M. (2005). The homeopathic preparation Vertigoheel versus Ginkgo biloba in the treatment of vertigo in an elderly population: a double-blinded, randomized, controlled clinical trial. Journal of Alternative and Complementary Medicine (New York, N.Y.), 11(1), pp. 155-60.
Issing W, Klein P, Weiser M. The Homeopathic Preparation Vertigoheel Versus Ginkgo Biloba in the Treatment of Vertigo in an Elderly Population: a Double-blinded, Randomized, Controlled Clinical Trial. J Altern Complement Med. 2005;11(1):155-60. PubMed PMID: 15750375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The homeopathic preparation Vertigoheel versus Ginkgo biloba in the treatment of vertigo in an elderly population: a double-blinded, randomized, controlled clinical trial. AU - Issing,Wolfgang, AU - Klein,Peter, AU - Weiser,Michael, PY - 2005/3/8/pubmed PY - 2005/5/25/medline PY - 2005/3/8/entrez SP - 155 EP - 60 JF - Journal of alternative and complementary medicine (New York, N.Y.) JO - J Altern Complement Med VL - 11 IS - 1 N2 - OBJECTIVE: Alternative medical practices are common in the treatment of vertigo. This study compared the effects of Ginkgo biloba treatment with the homeopathic remedy Vertigoheel (Biologische Heilmittel Heel GmbH, Baden-Baden, Germany). DESIGN: Randomized, double-blinded, parallel group study. SUBJECTS: One hundred and seventy (170) patients, ages 60-80 years, with atherosclerosis-related vertigo. INTERVENTIONS: Patients were randomly allocated to receive treatment with either Vertigoheel (n = 87) or G. biloba (n = 83). OUTCOME MEASURES: The results were analyzed for the non-inferiority of Vertigoheel to G. biloba on the combined endpoint of changes from baseline to week 6 in dizziness score (assessed by questionnaire), frequency, duration, and intensity of vertigo episodes (recorded in patient diaries). RESULTS: Both treatments improved vertigo status. From a baseline mean value of 26.1 +/- 5.2 (on a 50-point scale) in the Vertigoheel group, the dizziness questionnaire score improved by -10.6 +/- 10.0, and by -10.7 +/- 9.0 from 25.8 - 4.7 in the G. biloba group. Statistical analysis of this endpoint showed that Vertigoheel was not inferior to G. biloba. The 95% confidence interval for the difference between treatment did not reach the inferiority threshold of 0.36 at any of the time points tested. The results were supported by the results of a line walking test, Unterberger's stepping test, and patient and physician global assessments of therapeutic effect. Both treatments were well tolerated. CONCLUSIONS: Vertigoheel is an appealing alternative to established G. biloba therapy for atherosclerosis-related vertigo. SN - 1075-5535 UR - https://www.unboundmedicine.com/medline/citation/15750375/The_homeopathic_preparation_Vertigoheel_versus_Ginkgo_biloba_in_the_treatment_of_vertigo_in_an_elderly_population:_a_double_blinded_randomized_controlled_clinical_trial_ L2 - https://www.liebertpub.com/doi/full/10.1089/acm.2005.11.155?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -