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Elevation of plasma homocysteine in natural menopause can not be explained by a lack of vitamin coenzyme availability: relevance to the risk of cardiovascular disease.
J Nutr Health Aging. 2005; 9(1):59-64.JN

Abstract

The risk of cardio vascular disease (CVD) doubles after menopause. Plasma homocysteine (hCy) is a risk factor which is influenced by vitamins B12,B6 and folate. The present study was conducted to examine the relationship of plasma hCy to the three vitamins and other contributing variables in early natural menopause.

METHODS

Participants were healthy, non smoking Caucasian women 3 to 5 years postmenopausal (n = 26) or premenopausal between 30 and 45 y(n = 30). Anthropometric data, dietary records and plasma concentrations of hCy, vitamin B6, vitamin B12 and folate were obtained.

RESULTS

The nutritional status of vitamins B6, B12 and folate as measured by dietary intake and blood concentrations was adequate in both groups. Mean fasting plasma total (t) hCy concentration of postmenopausal group was 2-fold higher than the value found for control group (P < 0.0001) without oral methionine loading. The difference between the two groups remained highly significant after adjustment for confounding variables by multivariate analysis, suggesting that the effect of estrogen deficiency was direct.

CONCLUSION

In addition to the loss of the protective effects of estrogen on their cardiovascular physiology and lipid metabolism, postmenopausal women are exposed to higher plasma hCy concentrations and deleterious cardiovascular effects. The exact mechanism is not known but does not seem to be related to coenzyme deficiency.

Authors+Show Affiliations

Masse PG
School of Nutrition, University of Moncton, New Brunswick, Canada E1A 3E9.
Dosy J
No affiliation info available
Cole DE
No affiliation info available
Evrovski J
No affiliation info available
Mahuren JD
No affiliation info available
Coburn SP
No affiliation info available

MeSH

AdultCardiovascular DiseasesCoenzymesDietEstrogensFemaleFolic AcidHomocysteineHumansMenopauseMiddle AgedRisk FactorsVitamin B 12Vitamin B 6

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15750667

Citation

Masse, P G., et al. "Elevation of Plasma Homocysteine in Natural Menopause Can Not Be Explained By a Lack of Vitamin Coenzyme Availability: Relevance to the Risk of Cardiovascular Disease." The Journal of Nutrition, Health & Aging, vol. 9, no. 1, 2005, pp. 59-64.
Masse PG, Dosy J, Cole DE, et al. Elevation of plasma homocysteine in natural menopause can not be explained by a lack of vitamin coenzyme availability: relevance to the risk of cardiovascular disease. J Nutr Health Aging. 2005;9(1):59-64.
Masse, P. G., Dosy, J., Cole, D. E., Evrovski, J., Mahuren, J. D., & Coburn, S. P. (2005). Elevation of plasma homocysteine in natural menopause can not be explained by a lack of vitamin coenzyme availability: relevance to the risk of cardiovascular disease. The Journal of Nutrition, Health & Aging, 9(1), 59-64.
Masse PG, et al. Elevation of Plasma Homocysteine in Natural Menopause Can Not Be Explained By a Lack of Vitamin Coenzyme Availability: Relevance to the Risk of Cardiovascular Disease. J Nutr Health Aging. 2005;9(1):59-64. PubMed PMID: 15750667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevation of plasma homocysteine in natural menopause can not be explained by a lack of vitamin coenzyme availability: relevance to the risk of cardiovascular disease. AU - Masse,P G, AU - Dosy,J, AU - Cole,D E C, AU - Evrovski,J, AU - Mahuren,J D, AU - Coburn,S P, PY - 2005/3/8/pubmed PY - 2005/10/18/medline PY - 2005/3/8/entrez SP - 59 EP - 64 JF - The journal of nutrition, health & aging JO - J Nutr Health Aging VL - 9 IS - 1 N2 - UNLABELLED: The risk of cardio vascular disease (CVD) doubles after menopause. Plasma homocysteine (hCy) is a risk factor which is influenced by vitamins B12,B6 and folate. The present study was conducted to examine the relationship of plasma hCy to the three vitamins and other contributing variables in early natural menopause. METHODS: Participants were healthy, non smoking Caucasian women 3 to 5 years postmenopausal (n = 26) or premenopausal between 30 and 45 y(n = 30). Anthropometric data, dietary records and plasma concentrations of hCy, vitamin B6, vitamin B12 and folate were obtained. RESULTS: The nutritional status of vitamins B6, B12 and folate as measured by dietary intake and blood concentrations was adequate in both groups. Mean fasting plasma total (t) hCy concentration of postmenopausal group was 2-fold higher than the value found for control group (P < 0.0001) without oral methionine loading. The difference between the two groups remained highly significant after adjustment for confounding variables by multivariate analysis, suggesting that the effect of estrogen deficiency was direct. CONCLUSION: In addition to the loss of the protective effects of estrogen on their cardiovascular physiology and lipid metabolism, postmenopausal women are exposed to higher plasma hCy concentrations and deleterious cardiovascular effects. The exact mechanism is not known but does not seem to be related to coenzyme deficiency. SN - 1279-7707 UR - https://www.unboundmedicine.com/medline/citation/15750667/Elevation_of_plasma_homocysteine_in_natural_menopause_can_not_be_explained_by_a_lack_of_vitamin_coenzyme_availability:_relevance_to_the_risk_of_cardiovascular_disease_ DB - PRIME DP - Unbound Medicine ER -