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Transepidermal water loss and skin capacitance alterations among workers in an ultra-low humidity environment.
Arch Dermatol Res. 2005 Apr; 296(10):489-95.AD

Abstract

No studies have been performed evaluating skin barrier alterations in humans exposed to ultra-low humidity (ULH) in spite of several lines of evidence from animal experiments suggesting that the skin barrier is altered on exposure to ULH. The objectives of this study were to assess barrier function changes in workers occupationally exposed to ULH (relative humidity 1.5%), and to evaluate whether the exposure duration shows a dose-response relationship with transepidermal water loss (TEWL) and skin capacitance. A total of 49 male workers exposed to ULH for 12 h per working day were classified into five subgroups based on their ULH exposure duration (<0.5 months, 0.5-1.0 month, 1.1-10.0 months, 10.1-20.0 months, and >20.0 months). A group of 12 age-matched male laboratory workers from a normal humidity environment were recruited as a control group. TEWL and skin capacitance were measured to evaluate their skin barrier function. TEWL measurements showed a significant decline (8.3+/-0.4 vs 10.0+/-0.4 g m(-2) h(-1), P < 0.05) but no differences were found in skin capacitance (39.7+/-1.3 a.u. vs 45.0+/-2.4 a.u., P = 0.68) between the whole ULH exposure group and the control group. Maximum decreases in TEWL and skin capacitance were seen in the subgroups exposed for <0.5 months and 0.5-1.0 month, respectively. Almost completely natural recovery occurred in skin capacitance after 20 months ULH exposure, in contrast to less than 90% recovery in TEWL. Three stages were defined according to the pattern of alterations in TEWL and skin capacitance in relation to ULH exposure duration. A positive association between TEWL and skin capacitance occurred in the control group and stage I but a negative correlation in stage II. No correlation was found in stage III. Our study demonstrated that workers exposed to a ULH environment could exhibit skin barrier alterations. Both TEWL and skin capacitance decreased within 2 weeks of ULH exposure. The maximum alterations in TEWL and skin capacitance occurred during 0.5-1.0 months and 2 weeks, respectively. TEWL recovered partially and more slowly than skin capacitance which recovered earlier and almost completely.

Authors+Show Affiliations

Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, 704, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15750803

Citation

Chou, Tzu-Chieh, et al. "Transepidermal Water Loss and Skin Capacitance Alterations Among Workers in an Ultra-low Humidity Environment." Archives of Dermatological Research, vol. 296, no. 10, 2005, pp. 489-95.
Chou TC, Lin KH, Wang SM, et al. Transepidermal water loss and skin capacitance alterations among workers in an ultra-low humidity environment. Arch Dermatol Res. 2005;296(10):489-95.
Chou, T. C., Lin, K. H., Wang, S. M., Lee, C. W., Su, S. B., Shih, T. S., & Chang, H. Y. (2005). Transepidermal water loss and skin capacitance alterations among workers in an ultra-low humidity environment. Archives of Dermatological Research, 296(10), 489-95.
Chou TC, et al. Transepidermal Water Loss and Skin Capacitance Alterations Among Workers in an Ultra-low Humidity Environment. Arch Dermatol Res. 2005;296(10):489-95. PubMed PMID: 15750803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transepidermal water loss and skin capacitance alterations among workers in an ultra-low humidity environment. AU - Chou,Tzu-Chieh, AU - Lin,Kuen-Huei, AU - Wang,Shih-Min, AU - Lee,Chia-Wei, AU - Su,Shih-Bin, AU - Shih,Tung-Sheng, AU - Chang,Ho-Yuan, Y1 - 2005/03/05/ PY - 2004/10/28/received PY - 2005/01/04/accepted PY - 2004/12/21/revised PY - 2005/3/8/pubmed PY - 2005/10/29/medline PY - 2005/3/8/entrez SP - 489 EP - 95 JF - Archives of dermatological research JO - Arch. Dermatol. Res. VL - 296 IS - 10 N2 - No studies have been performed evaluating skin barrier alterations in humans exposed to ultra-low humidity (ULH) in spite of several lines of evidence from animal experiments suggesting that the skin barrier is altered on exposure to ULH. The objectives of this study were to assess barrier function changes in workers occupationally exposed to ULH (relative humidity 1.5%), and to evaluate whether the exposure duration shows a dose-response relationship with transepidermal water loss (TEWL) and skin capacitance. A total of 49 male workers exposed to ULH for 12 h per working day were classified into five subgroups based on their ULH exposure duration (<0.5 months, 0.5-1.0 month, 1.1-10.0 months, 10.1-20.0 months, and >20.0 months). A group of 12 age-matched male laboratory workers from a normal humidity environment were recruited as a control group. TEWL and skin capacitance were measured to evaluate their skin barrier function. TEWL measurements showed a significant decline (8.3+/-0.4 vs 10.0+/-0.4 g m(-2) h(-1), P < 0.05) but no differences were found in skin capacitance (39.7+/-1.3 a.u. vs 45.0+/-2.4 a.u., P = 0.68) between the whole ULH exposure group and the control group. Maximum decreases in TEWL and skin capacitance were seen in the subgroups exposed for <0.5 months and 0.5-1.0 month, respectively. Almost completely natural recovery occurred in skin capacitance after 20 months ULH exposure, in contrast to less than 90% recovery in TEWL. Three stages were defined according to the pattern of alterations in TEWL and skin capacitance in relation to ULH exposure duration. A positive association between TEWL and skin capacitance occurred in the control group and stage I but a negative correlation in stage II. No correlation was found in stage III. Our study demonstrated that workers exposed to a ULH environment could exhibit skin barrier alterations. Both TEWL and skin capacitance decreased within 2 weeks of ULH exposure. The maximum alterations in TEWL and skin capacitance occurred during 0.5-1.0 months and 2 weeks, respectively. TEWL recovered partially and more slowly than skin capacitance which recovered earlier and almost completely. SN - 0340-3696 UR - https://www.unboundmedicine.com/medline/citation/15750803/Transepidermal_water_loss_and_skin_capacitance_alterations_among_workers_in_an_ultra_low_humidity_environment_ L2 - https://link.springer.com/article/10.1007/s00403-005-0541-4 DB - PRIME DP - Unbound Medicine ER -