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Preparation and in vitro evaluation of sustained release tablet formulations of diclofenac sodium.
Farmaco. 2005 Feb; 60(2):171-7.F

Abstract

The effects of formulation variables on the release profile of diclofenac sodium (DS) from hydroxypropylmethyl cellulose (HPMC) and chitosan matrix tablets were studied. DS tablets were prepared by wet granulation and direct compression methods and different ratios of HPMC and chitosan were used. Physical properties of the prepared tablets and targeted commercial sustained release (SR) tablet and the drug release were studied in tablets that were placed in 0.1 M HCl for 1 h and phosphate buffer solution was added to reach pH value of 7.5. In vitro studies showed that 20% HPMC contained SR formulation with direct (dry) compression method is the optimum formulation due to its better targeting profile in terms of release. This formulation also exhibited the best-fitted formulation into the zero order kinetics. The precision and accuracy of the analytical method were also checked. The repeatability and reproducibility of the method were also determined.

Authors+Show Affiliations

Department of Pharmaceutical Technology, Gülhane Military Medical Academy, Etlik, 06018 Ankara, Turkey.No affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

15752476

Citation

Savaşer, Ayhan, et al. "Preparation and in Vitro Evaluation of Sustained Release Tablet Formulations of Diclofenac Sodium." Farmaco (Societa Chimica Italiana : 1989), vol. 60, no. 2, 2005, pp. 171-7.
Savaşer A, Ozkan Y, Işimer A. Preparation and in vitro evaluation of sustained release tablet formulations of diclofenac sodium. Farmaco. 2005;60(2):171-7.
Savaşer, A., Ozkan, Y., & Işimer, A. (2005). Preparation and in vitro evaluation of sustained release tablet formulations of diclofenac sodium. Farmaco (Societa Chimica Italiana : 1989), 60(2), 171-7.
Savaşer A, Ozkan Y, Işimer A. Preparation and in Vitro Evaluation of Sustained Release Tablet Formulations of Diclofenac Sodium. Farmaco. 2005;60(2):171-7. PubMed PMID: 15752476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and in vitro evaluation of sustained release tablet formulations of diclofenac sodium. AU - Savaşer,Ayhan, AU - Ozkan,Yalçin, AU - Işimer,Aşkin, Y1 - 2005/01/07/ PY - 2003/11/11/received PY - 2004/10/18/accepted PY - 2005/3/9/pubmed PY - 2005/7/9/medline PY - 2005/3/9/entrez SP - 171 EP - 7 JF - Farmaco (Societa chimica italiana : 1989) JO - Farmaco VL - 60 IS - 2 N2 - The effects of formulation variables on the release profile of diclofenac sodium (DS) from hydroxypropylmethyl cellulose (HPMC) and chitosan matrix tablets were studied. DS tablets were prepared by wet granulation and direct compression methods and different ratios of HPMC and chitosan were used. Physical properties of the prepared tablets and targeted commercial sustained release (SR) tablet and the drug release were studied in tablets that were placed in 0.1 M HCl for 1 h and phosphate buffer solution was added to reach pH value of 7.5. In vitro studies showed that 20% HPMC contained SR formulation with direct (dry) compression method is the optimum formulation due to its better targeting profile in terms of release. This formulation also exhibited the best-fitted formulation into the zero order kinetics. The precision and accuracy of the analytical method were also checked. The repeatability and reproducibility of the method were also determined. SN - 0014-827X UR - https://www.unboundmedicine.com/medline/citation/15752476/Preparation_and_in_vitro_evaluation_of_sustained_release_tablet_formulations_of_diclofenac_sodium_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-827X(04)00212-5 DB - PRIME DP - Unbound Medicine ER -