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Screening of Indonesian medicinal plants for inhibitor activity on nitric oxide production of RAW264.7 cells and antioxidant activity.
Fitoterapia. 2005 Mar; 76(2):194-203.F

Abstract

Traditional Indonesian medicinal plants were screened for their inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and for the antioxidant activity through the evaluation of free radical scavenging effect and reducing power. The results of screening indicated that 50 methanolic extracts inhibited (>50%) lipopolysaccharides (LPS)-induced NO release from RAW264.7 cells at 50 microg/ml, with 18 having greater than 100% inhibition. At 200 microg/ml, 61 methanol extracts exhibited inhibitory activity (>50%), with 45 showing greater than 100% inhibition. In addition, the free radical scavenging effects of 6 methanolic extracts were found to be more than 50% for extract concentration of 0.5 mug/ml. The results indicate that the extracts contain active compounds that inhibit NO release and scavenge free radical.

Authors+Show Affiliations

Department of Biotechnology and Bioproducts Research Center, Yonsei University, Shinchon-dong 134, Seodaemun-gu, Seoul, 120-749, Korea.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15752630

Citation

Choi, Eun-Mi, and Jae-Kwan Hwang. "Screening of Indonesian Medicinal Plants for Inhibitor Activity On Nitric Oxide Production of RAW264.7 Cells and Antioxidant Activity." Fitoterapia, vol. 76, no. 2, 2005, pp. 194-203.
Choi EM, Hwang JK. Screening of Indonesian medicinal plants for inhibitor activity on nitric oxide production of RAW264.7 cells and antioxidant activity. Fitoterapia. 2005;76(2):194-203.
Choi, E. M., & Hwang, J. K. (2005). Screening of Indonesian medicinal plants for inhibitor activity on nitric oxide production of RAW264.7 cells and antioxidant activity. Fitoterapia, 76(2), 194-203.
Choi EM, Hwang JK. Screening of Indonesian Medicinal Plants for Inhibitor Activity On Nitric Oxide Production of RAW264.7 Cells and Antioxidant Activity. Fitoterapia. 2005;76(2):194-203. PubMed PMID: 15752630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Screening of Indonesian medicinal plants for inhibitor activity on nitric oxide production of RAW264.7 cells and antioxidant activity. AU - Choi,Eun-Mi, AU - Hwang,Jae-Kwan, PY - 2004/07/29/received PY - 2004/11/29/accepted PY - 2005/3/9/pubmed PY - 2005/4/22/medline PY - 2005/3/9/entrez SP - 194 EP - 203 JF - Fitoterapia JO - Fitoterapia VL - 76 IS - 2 N2 - Traditional Indonesian medicinal plants were screened for their inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and for the antioxidant activity through the evaluation of free radical scavenging effect and reducing power. The results of screening indicated that 50 methanolic extracts inhibited (>50%) lipopolysaccharides (LPS)-induced NO release from RAW264.7 cells at 50 microg/ml, with 18 having greater than 100% inhibition. At 200 microg/ml, 61 methanol extracts exhibited inhibitory activity (>50%), with 45 showing greater than 100% inhibition. In addition, the free radical scavenging effects of 6 methanolic extracts were found to be more than 50% for extract concentration of 0.5 mug/ml. The results indicate that the extracts contain active compounds that inhibit NO release and scavenge free radical. SN - 0367-326X UR - https://www.unboundmedicine.com/medline/citation/15752630/Screening_of_Indonesian_medicinal_plants_for_inhibitor_activity_on_nitric_oxide_production_of_RAW264_7_cells_and_antioxidant_activity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367-326X(04)00266-7 DB - PRIME DP - Unbound Medicine ER -