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Vitamin E and cardiovascular disease: observational studies.
Ann N Y Acad Sci 2004; 1031:280-91AN

Abstract

Basic research suggests that oxidative stress may play an important role in many chronic diseases and provides plausible mechanisms by which natural antioxidants such as vitamin E may delay or prevent steps in atherogenesis. Dietary research has shown that those who consume higher amounts of fruits and vegetables have lower rates of heart disease and stroke, raising the possibility that antioxidants are protective. Results from large-scale human observational studies suggest that antioxidant consumption reduces the risk of developing cardiovascular disease (CVD). Both case-control and prospective cohort studies have carefully explored the relationship between vitamin E intake and plasma and tissue vitamin E levels and the risk of CVD. In many, but not all, of these studies vitamin E intake over an extended period was associated with decreased risk of cardiovascular events. Results from studies of blood levels are more limited and less consistent. This presentation summarizes data from the major observational studies. Overall, they support the possibility that vitamin E intake either from food or supplements may reduce risk of CVD; however, these studies have important limitations. For example, uncontrolled confounding can be similar in magnitude to the observed health effects, and antioxidant consumption may be merely a marker for a different cardioprotective factor (such as exercise or diet) that is responsible for these effects. In the search for small to moderate effects, randomized trials may be helpful, although to date, data from large-scale trials have been inconsistent. Several large-scale trials currently under way will help identify the potential benefits of vitamin E in the primary prevention of CVD and other chronic illness. Some are designed to test vitamin E alone as well as in combination with other antioxidant supplements because it is possible that antioxidants may be most effective if taken in particular combinations. Currently, the American Heart Association maintains that there are insufficient efficacy data from completed randomized trials to justify population-wide recommendations for use of vitamin E supplements in disease prevention.

Authors+Show Affiliations

Brigham and Women's Hospital, Division of Aging, 1620 Tremont Street, Boston MA 02120, USA. jmgaziano@partners.org

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15753154

Citation

Gaziano, J Michael. "Vitamin E and Cardiovascular Disease: Observational Studies." Annals of the New York Academy of Sciences, vol. 1031, 2004, pp. 280-91.
Gaziano JM. Vitamin E and cardiovascular disease: observational studies. Ann N Y Acad Sci. 2004;1031:280-91.
Gaziano, J. M. (2004). Vitamin E and cardiovascular disease: observational studies. Annals of the New York Academy of Sciences, 1031, pp. 280-91.
Gaziano JM. Vitamin E and Cardiovascular Disease: Observational Studies. Ann N Y Acad Sci. 2004;1031:280-91. PubMed PMID: 15753154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin E and cardiovascular disease: observational studies. A1 - Gaziano,J Michael, PY - 2005/3/9/pubmed PY - 2005/6/16/medline PY - 2005/3/9/entrez SP - 280 EP - 91 JF - Annals of the New York Academy of Sciences JO - Ann. N. Y. Acad. Sci. VL - 1031 N2 - Basic research suggests that oxidative stress may play an important role in many chronic diseases and provides plausible mechanisms by which natural antioxidants such as vitamin E may delay or prevent steps in atherogenesis. Dietary research has shown that those who consume higher amounts of fruits and vegetables have lower rates of heart disease and stroke, raising the possibility that antioxidants are protective. Results from large-scale human observational studies suggest that antioxidant consumption reduces the risk of developing cardiovascular disease (CVD). Both case-control and prospective cohort studies have carefully explored the relationship between vitamin E intake and plasma and tissue vitamin E levels and the risk of CVD. In many, but not all, of these studies vitamin E intake over an extended period was associated with decreased risk of cardiovascular events. Results from studies of blood levels are more limited and less consistent. This presentation summarizes data from the major observational studies. Overall, they support the possibility that vitamin E intake either from food or supplements may reduce risk of CVD; however, these studies have important limitations. For example, uncontrolled confounding can be similar in magnitude to the observed health effects, and antioxidant consumption may be merely a marker for a different cardioprotective factor (such as exercise or diet) that is responsible for these effects. In the search for small to moderate effects, randomized trials may be helpful, although to date, data from large-scale trials have been inconsistent. Several large-scale trials currently under way will help identify the potential benefits of vitamin E in the primary prevention of CVD and other chronic illness. Some are designed to test vitamin E alone as well as in combination with other antioxidant supplements because it is possible that antioxidants may be most effective if taken in particular combinations. Currently, the American Heart Association maintains that there are insufficient efficacy data from completed randomized trials to justify population-wide recommendations for use of vitamin E supplements in disease prevention. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/15753154/Vitamin_E_and_cardiovascular_disease:_observational_studies_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0077-8923&date=2004&volume=1031&spage=280 DB - PRIME DP - Unbound Medicine ER -