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Temporal lobe atrophy on MRI in Parkinson disease with dementia: a comparison with Alzheimer disease and dementia with Lewy bodies.
Neurology. 2005 Mar 08; 64(5):861-5.Neur

Abstract

OBJECTIVE

To investigate the extent of medial temporal lobe atrophy (MTA) on MRI in Parkinson disease (PD) with and without dementia compared with Alzheimer disease (AD) and dementia with Lewy bodies (DLB) and to determine whether MTA correlates with cognitive impairment in PD and PD dementia (PDD).

METHODS

Coronal T1-weighted MRI scans were acquired from control subjects (n = 39) and patients with PD (n = 33), PDD (n = 31), DLB (n = 25), and AD (n = 31), diagnosed according to standardized clinical diagnostic criteria. Cognitive function was assessed using the Cambridge Cognitive Examination (CAMCOG), and MTA was rated visually using a standardized (Scheltens) scale.

RESULTS

More severe MTA was seen in PDD (p = 0.007), DLB (p < 0.001), and AD (p < 0.001) vs control subjects. PD subjects had greater hippocampal atrophy than control subjects (p = 0.015) but less than subjects with DLB and AD, though not with PDD. MTA correlated with CAMCOG score and memory scores in the DLB group and with age in control, PDD, and AD groups. There were no correlations between MTA and cognitive impairment in PD, PDD, and AD. PDD and DLB had a similar profile of cognitive impairment and MTA.

CONCLUSIONS

Medial temporal lobe atrophy (MTA) was seen in cognitively intact older subjects with Parkinson disease (PD) and was not more pronounced in Parkinson disease dementia (PDD). Alzheimer disease (AD) and, to a lesser extent, dementia with Lewy bodies (DLB) showed more pronounced MTA. Results suggest early hippocampal involvement in PD and that when dementia develops in PD, anatomic structures apart from the hippocampus are predominantly implicated. Greater hippocampal involvement in AD vs PDD and DLB is consistent with clinical, cognitive, and pathologic differences between the disorders.

Authors+Show Affiliations

Department of Psychiatry, Tai Po Hospital, Hong Kong.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15753423

Citation

Tam, C W C., et al. "Temporal Lobe Atrophy On MRI in Parkinson Disease With Dementia: a Comparison With Alzheimer Disease and Dementia With Lewy Bodies." Neurology, vol. 64, no. 5, 2005, pp. 861-5.
Tam CW, Burton EJ, McKeith IG, et al. Temporal lobe atrophy on MRI in Parkinson disease with dementia: a comparison with Alzheimer disease and dementia with Lewy bodies. Neurology. 2005;64(5):861-5.
Tam, C. W., Burton, E. J., McKeith, I. G., Burn, D. J., & O'Brien, J. T. (2005). Temporal lobe atrophy on MRI in Parkinson disease with dementia: a comparison with Alzheimer disease and dementia with Lewy bodies. Neurology, 64(5), 861-5.
Tam CW, et al. Temporal Lobe Atrophy On MRI in Parkinson Disease With Dementia: a Comparison With Alzheimer Disease and Dementia With Lewy Bodies. Neurology. 2005 Mar 8;64(5):861-5. PubMed PMID: 15753423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Temporal lobe atrophy on MRI in Parkinson disease with dementia: a comparison with Alzheimer disease and dementia with Lewy bodies. AU - Tam,C W C, AU - Burton,E J, AU - McKeith,I G, AU - Burn,D J, AU - O'Brien,J T, PY - 2005/3/9/pubmed PY - 2006/2/10/medline PY - 2005/3/9/entrez SP - 861 EP - 5 JF - Neurology JO - Neurology VL - 64 IS - 5 N2 - OBJECTIVE: To investigate the extent of medial temporal lobe atrophy (MTA) on MRI in Parkinson disease (PD) with and without dementia compared with Alzheimer disease (AD) and dementia with Lewy bodies (DLB) and to determine whether MTA correlates with cognitive impairment in PD and PD dementia (PDD). METHODS: Coronal T1-weighted MRI scans were acquired from control subjects (n = 39) and patients with PD (n = 33), PDD (n = 31), DLB (n = 25), and AD (n = 31), diagnosed according to standardized clinical diagnostic criteria. Cognitive function was assessed using the Cambridge Cognitive Examination (CAMCOG), and MTA was rated visually using a standardized (Scheltens) scale. RESULTS: More severe MTA was seen in PDD (p = 0.007), DLB (p < 0.001), and AD (p < 0.001) vs control subjects. PD subjects had greater hippocampal atrophy than control subjects (p = 0.015) but less than subjects with DLB and AD, though not with PDD. MTA correlated with CAMCOG score and memory scores in the DLB group and with age in control, PDD, and AD groups. There were no correlations between MTA and cognitive impairment in PD, PDD, and AD. PDD and DLB had a similar profile of cognitive impairment and MTA. CONCLUSIONS: Medial temporal lobe atrophy (MTA) was seen in cognitively intact older subjects with Parkinson disease (PD) and was not more pronounced in Parkinson disease dementia (PDD). Alzheimer disease (AD) and, to a lesser extent, dementia with Lewy bodies (DLB) showed more pronounced MTA. Results suggest early hippocampal involvement in PD and that when dementia develops in PD, anatomic structures apart from the hippocampus are predominantly implicated. Greater hippocampal involvement in AD vs PDD and DLB is consistent with clinical, cognitive, and pathologic differences between the disorders. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/15753423/Temporal_lobe_atrophy_on_MRI_in_Parkinson_disease_with_dementia:_a_comparison_with_Alzheimer_disease_and_dementia_with_Lewy_bodies_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&amp;pmid=15753423 DB - PRIME DP - Unbound Medicine ER -