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Increased levels of interleukin-18 in bronchoalveolar lavage fluid of patients with idiopathic nonspecific interstitial pneumonia.
Respiration. 2005 Jan-Feb; 72(1):39-45.R

Abstract

BACKGROUND

Interleukin-18 (IL-18) is a proinflammatory cytokine that can induce interferon-gamma (IFN-gamma), and it plays an important role in T-helper 1 responses. Among idiopathic interstitial pneumonia (IIP), nonspecific interstitial pneumonia (NSIP) has an increased number of lymphocytes in bronchoalveolar lavage (BAL) fluid compared with usual interstitial pneumonia (UIP). However, the difference in their pathogenesis is unclear.

OBJECTIVE

The present study aims to investigate the roles of IL-18 in patients with idiopathic UIP and idiopathic NSIP.

METHODS

We measured the serum and BAL fluid (BALF) levels of IL-18 and IFN-gamma in 22 patients with IIP (12 with UIP, 10 with NSIP) and 9 healthy volunteers.

RESULTS

Lymphocyte proportions in BALF were significantly higher in NSIP than in UIP and healthy subjects. No significant differences were observed in the serum IL-18 levels of all subjects, while the BALF levels of IL-18 in patients with NSIP were significantly higher than in patients with UIP (p < 0.005) and in healthy subjects (p < 0.005). Among all subjects, the levels of IL-18 in BALF correlated significantly with those in serum and the lymphocyte proportions in BALF. The serum IFN-gamma levels of all subjects were below sensitivity, but there was significant reverse correlation between the levels of IFN-gamma and the lymphocyte proportions in BALF.

CONCLUSION

The lymphocytosis in BALF of patients with idiopathic NSIP and a part of idiopathic UIP might be associated with the high levels of IL-18.

Authors+Show Affiliations

Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15753633

Citation

Ishii, Hiroshi, et al. "Increased Levels of Interleukin-18 in Bronchoalveolar Lavage Fluid of Patients With Idiopathic Nonspecific Interstitial Pneumonia." Respiration; International Review of Thoracic Diseases, vol. 72, no. 1, 2005, pp. 39-45.
Ishii H, Mukae H, Kadota J, et al. Increased levels of interleukin-18 in bronchoalveolar lavage fluid of patients with idiopathic nonspecific interstitial pneumonia. Respiration. 2005;72(1):39-45.
Ishii, H., Mukae, H., Kadota, J., Fujii, T., Abe, K., Ashitani, J., & Kohno, S. (2005). Increased levels of interleukin-18 in bronchoalveolar lavage fluid of patients with idiopathic nonspecific interstitial pneumonia. Respiration; International Review of Thoracic Diseases, 72(1), 39-45.
Ishii H, et al. Increased Levels of Interleukin-18 in Bronchoalveolar Lavage Fluid of Patients With Idiopathic Nonspecific Interstitial Pneumonia. Respiration. 2005 Jan-Feb;72(1):39-45. PubMed PMID: 15753633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased levels of interleukin-18 in bronchoalveolar lavage fluid of patients with idiopathic nonspecific interstitial pneumonia. AU - Ishii,Hiroshi, AU - Mukae,Hiroshi, AU - Kadota,Jun-ichi, AU - Fujii,Takeshi, AU - Abe,Koh, AU - Ashitani,Jun-ichi, AU - Kohno,Shigeru, PY - 2003/07/22/received PY - 2004/06/07/accepted PY - 2005/3/9/pubmed PY - 2005/6/1/medline PY - 2005/3/9/entrez SP - 39 EP - 45 JF - Respiration; international review of thoracic diseases JO - Respiration VL - 72 IS - 1 N2 - BACKGROUND: Interleukin-18 (IL-18) is a proinflammatory cytokine that can induce interferon-gamma (IFN-gamma), and it plays an important role in T-helper 1 responses. Among idiopathic interstitial pneumonia (IIP), nonspecific interstitial pneumonia (NSIP) has an increased number of lymphocytes in bronchoalveolar lavage (BAL) fluid compared with usual interstitial pneumonia (UIP). However, the difference in their pathogenesis is unclear. OBJECTIVE: The present study aims to investigate the roles of IL-18 in patients with idiopathic UIP and idiopathic NSIP. METHODS: We measured the serum and BAL fluid (BALF) levels of IL-18 and IFN-gamma in 22 patients with IIP (12 with UIP, 10 with NSIP) and 9 healthy volunteers. RESULTS: Lymphocyte proportions in BALF were significantly higher in NSIP than in UIP and healthy subjects. No significant differences were observed in the serum IL-18 levels of all subjects, while the BALF levels of IL-18 in patients with NSIP were significantly higher than in patients with UIP (p < 0.005) and in healthy subjects (p < 0.005). Among all subjects, the levels of IL-18 in BALF correlated significantly with those in serum and the lymphocyte proportions in BALF. The serum IFN-gamma levels of all subjects were below sensitivity, but there was significant reverse correlation between the levels of IFN-gamma and the lymphocyte proportions in BALF. CONCLUSION: The lymphocytosis in BALF of patients with idiopathic NSIP and a part of idiopathic UIP might be associated with the high levels of IL-18. SN - 0025-7931 UR - https://www.unboundmedicine.com/medline/citation/15753633/Increased_levels_of_interleukin_18_in_bronchoalveolar_lavage_fluid_of_patients_with_idiopathic_nonspecific_interstitial_pneumonia_ L2 - https://www.karger.com?DOI=10.1159/000083399 DB - PRIME DP - Unbound Medicine ER -