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Inner City Asthma Study: relationships among sensitivity, allergen exposure, and asthma morbidity.
J Allergy Clin Immunol 2005; 115(3):478-85JA

Abstract

BACKGROUND

Asthma-associated morbidity is rising, especially in inner city children.

OBJECTIVE

We evaluated the allergen sensitivities, allergen exposures, and associated morbidity for participants in the Inner City Asthma Study. We also determined geographic variations of indoor allergen levels.

METHODS

Nine hundred thirty-seven inner city children 5 to 11 years old with moderate to severe asthma underwent allergen skin testing. Bedroom dust samples were evaluated for Der p 1, Der f 1, Bla g 1, Fel d 1, and Can f 1.

RESULTS

Skin test sensitivities to cockroach (69%), dust mites (62%), and molds (50%) predominated, with marked study site-specific differences. Cockroach sensitivity was highest in the Bronx, New York, and Dallas (81.2%, 78.7%, and 78.5%, respectively), and dust mite sensitivity was highest in Dallas and Seattle (83.7% and 78.0%, respectively). A majority of homes in Chicago, New York, and the Bronx had cockroach allergen levels greater than 2 U/g, and a majority of those in Dallas and Seattle had dust mite allergen levels greater than 2 microg/g. Levels of both of these allergens were influenced by housing type. Cockroach allergen levels were highest in high-rise apartments, whereas dust mite allergen levels were highest in detached homes. Children who were both sensitive and exposed to cockroach allergen had significantly more asthma symptom days, more caretaker interrupted sleep, and more school days missed than children who were not sensitive or exposed.

CONCLUSION

Geographic differences in allergen exposure and sensitivity exist among inner city children. Cockroach exposure and sensitivity predominate in the Northeast, whereas dust mite exposure and sensitivity are highest in the South and Northwest. Cockroach allergen appears to have a greater effect on asthma morbidity than dust mite or pet allergen in these children.

Authors+Show Affiliations

University of Texas Southwestern Medical Center at Dallas, 75390-8859, USA. Rebecca.Gruchalla@utsouthwestern.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15753892

Citation

Gruchalla, Rebecca S., et al. "Inner City Asthma Study: Relationships Among Sensitivity, Allergen Exposure, and Asthma Morbidity." The Journal of Allergy and Clinical Immunology, vol. 115, no. 3, 2005, pp. 478-85.
Gruchalla RS, Pongracic J, Plaut M, et al. Inner City Asthma Study: relationships among sensitivity, allergen exposure, and asthma morbidity. J Allergy Clin Immunol. 2005;115(3):478-85.
Gruchalla, R. S., Pongracic, J., Plaut, M., Evans, R., Visness, C. M., Walter, M., ... Mitchell, H. (2005). Inner City Asthma Study: relationships among sensitivity, allergen exposure, and asthma morbidity. The Journal of Allergy and Clinical Immunology, 115(3), pp. 478-85.
Gruchalla RS, et al. Inner City Asthma Study: Relationships Among Sensitivity, Allergen Exposure, and Asthma Morbidity. J Allergy Clin Immunol. 2005;115(3):478-85. PubMed PMID: 15753892.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inner City Asthma Study: relationships among sensitivity, allergen exposure, and asthma morbidity. AU - Gruchalla,Rebecca S, AU - Pongracic,Jacqueline, AU - Plaut,Marshall, AU - Evans,Richard,3rd AU - Visness,Cynthia M, AU - Walter,Michelle, AU - Crain,Ellen F, AU - Kattan,Meyer, AU - Morgan,Wayne J, AU - Steinbach,Suzanne, AU - Stout,James, AU - Malindzak,George, AU - Smartt,Ernestine, AU - Mitchell,Herman, PY - 2005/3/9/pubmed PY - 2005/4/22/medline PY - 2005/3/9/entrez SP - 478 EP - 85 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 115 IS - 3 N2 - BACKGROUND: Asthma-associated morbidity is rising, especially in inner city children. OBJECTIVE: We evaluated the allergen sensitivities, allergen exposures, and associated morbidity for participants in the Inner City Asthma Study. We also determined geographic variations of indoor allergen levels. METHODS: Nine hundred thirty-seven inner city children 5 to 11 years old with moderate to severe asthma underwent allergen skin testing. Bedroom dust samples were evaluated for Der p 1, Der f 1, Bla g 1, Fel d 1, and Can f 1. RESULTS: Skin test sensitivities to cockroach (69%), dust mites (62%), and molds (50%) predominated, with marked study site-specific differences. Cockroach sensitivity was highest in the Bronx, New York, and Dallas (81.2%, 78.7%, and 78.5%, respectively), and dust mite sensitivity was highest in Dallas and Seattle (83.7% and 78.0%, respectively). A majority of homes in Chicago, New York, and the Bronx had cockroach allergen levels greater than 2 U/g, and a majority of those in Dallas and Seattle had dust mite allergen levels greater than 2 microg/g. Levels of both of these allergens were influenced by housing type. Cockroach allergen levels were highest in high-rise apartments, whereas dust mite allergen levels were highest in detached homes. Children who were both sensitive and exposed to cockroach allergen had significantly more asthma symptom days, more caretaker interrupted sleep, and more school days missed than children who were not sensitive or exposed. CONCLUSION: Geographic differences in allergen exposure and sensitivity exist among inner city children. Cockroach exposure and sensitivity predominate in the Northeast, whereas dust mite exposure and sensitivity are highest in the South and Northwest. Cockroach allergen appears to have a greater effect on asthma morbidity than dust mite or pet allergen in these children. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/15753892/Inner_City_Asthma_Study:_relationships_among_sensitivity_allergen_exposure_and_asthma_morbidity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091674904032270 DB - PRIME DP - Unbound Medicine ER -