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Vitamin D in normal and pathological parathyroid glands: new prospects for treating hyperparathyroidism (review).
Int J Mol Med 2005; 15(4):701-6IJ

Abstract

The secosteroid hormone active vitamin D [1,25(OH)2D3] is a key player in the regulation of calcium homeostasis and bone mineralization. In addition, it has antiproliferative and prodifferentiating effects on various cells in vitro and in vivo. The action of 1,25(OH)2D3 is mediated through the vitamin D receptor (VDR), which belongs to the superfamily of steroid/thyroid hormone nuclear receptors. VDR is expressed in the intestine, bone, kidney, parathyroid glands, and in many other tissues and cell types. In the parathyroid glands, 1,25(OH)2D3 markedly decreases parathyroid hormone gene transcription and parathyroid cell proliferation and induces parathyroid cell differentiation. Diminished VDR expression is frequent in parathyroid tumors and probably contributes to parathyroid tumorigenesis. The enzyme responsible for catalyzing synthesis of 1,25(OH)2D3 (1alpha-hydroxylase) has lately been demonstrated in the parathyroid glands. This indicates a new role for 1alpha-hydroxylase as an intracrine modulator of vitamin D function in non-renal tissues, which recently has been recognized as crucial in parathyroid tumor development. The growth-inhibitory properties of 1,25(OH)2D3 are prospects for treatment of hyperparathyroidism.

Authors+Show Affiliations

Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE-751 85 Uppsala, Sweden. pamela.correa@surgsci.uu.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15754035

Citation

Buchwald, Pamela Correa, et al. "Vitamin D in Normal and Pathological Parathyroid Glands: New Prospects for Treating Hyperparathyroidism (review)." International Journal of Molecular Medicine, vol. 15, no. 4, 2005, pp. 701-6.
Buchwald PC, Westin G, Akerström G. Vitamin D in normal and pathological parathyroid glands: new prospects for treating hyperparathyroidism (review). Int J Mol Med. 2005;15(4):701-6.
Buchwald, P. C., Westin, G., & Akerström, G. (2005). Vitamin D in normal and pathological parathyroid glands: new prospects for treating hyperparathyroidism (review). International Journal of Molecular Medicine, 15(4), pp. 701-6.
Buchwald PC, Westin G, Akerström G. Vitamin D in Normal and Pathological Parathyroid Glands: New Prospects for Treating Hyperparathyroidism (review). Int J Mol Med. 2005;15(4):701-6. PubMed PMID: 15754035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D in normal and pathological parathyroid glands: new prospects for treating hyperparathyroidism (review). AU - Buchwald,Pamela Correa, AU - Westin,Gunnar, AU - Akerström,Göran, PY - 2005/3/9/pubmed PY - 2005/8/5/medline PY - 2005/3/9/entrez SP - 701 EP - 6 JF - International journal of molecular medicine JO - Int. J. Mol. Med. VL - 15 IS - 4 N2 - The secosteroid hormone active vitamin D [1,25(OH)2D3] is a key player in the regulation of calcium homeostasis and bone mineralization. In addition, it has antiproliferative and prodifferentiating effects on various cells in vitro and in vivo. The action of 1,25(OH)2D3 is mediated through the vitamin D receptor (VDR), which belongs to the superfamily of steroid/thyroid hormone nuclear receptors. VDR is expressed in the intestine, bone, kidney, parathyroid glands, and in many other tissues and cell types. In the parathyroid glands, 1,25(OH)2D3 markedly decreases parathyroid hormone gene transcription and parathyroid cell proliferation and induces parathyroid cell differentiation. Diminished VDR expression is frequent in parathyroid tumors and probably contributes to parathyroid tumorigenesis. The enzyme responsible for catalyzing synthesis of 1,25(OH)2D3 (1alpha-hydroxylase) has lately been demonstrated in the parathyroid glands. This indicates a new role for 1alpha-hydroxylase as an intracrine modulator of vitamin D function in non-renal tissues, which recently has been recognized as crucial in parathyroid tumor development. The growth-inhibitory properties of 1,25(OH)2D3 are prospects for treatment of hyperparathyroidism. SN - 1107-3756 UR - https://www.unboundmedicine.com/medline/citation/15754035/Vitamin_D_in_normal_and_pathological_parathyroid_glands:_new_prospects_for_treating_hyperparathyroidism__review__ L2 - http://www.spandidos-publications.com/ijmm/15/4/701 DB - PRIME DP - Unbound Medicine ER -