Tags

Type your tag names separated by a space and hit enter

Dialyzer membrane permeability and survival in hemodialysis patients.
Am J Kidney Dis. 2005 Mar; 45(3):565-71.AJ

Abstract

BACKGROUND

We previously showed that nutritional protein concentrations were predictive of outcome, whereas variables reflecting body composition and dialysis dose were not, in a 30-month prospective follow-up of 1,610 hemodialysis patients. Information on dialysis membrane and erythropoietin use had to be evaluated in an additional follow-up.

METHODS

A subset of 650 patients from the initial cohort of 1,610 was analyzed for survival in a 2-year extension of follow-up. Detailed data were collected: demographics; cause of renal failure; time on dialysis therapy; type of membrane; erythropoietin treatment; body mass index (BMI); predialysis albumin, prealbumin, and bicarbonate levels; and outcome. Normalized protein catabolic rate (nPCR), dialysis adequacy, and lean body mass were computed from predialysis and postdialysis urea and creatinine values.

RESULTS

Patient characteristics were age of 61 +/- 16 years, 58% men, BMI of 22.7 +/- 4.4 kg/m2 , time on dialysis therapy of 102 +/- 73 months, and 8.8% had diabetes. Dialysis parameters were duration of 247 +/- 31 minutes, Kt/V of 1.4 +/- 0.3, and nPCR of 1.2 +/- 0.3 g/kg/d. Albumin level was 3.73 +/- 0.53 g/dL (37.3 +/- 5.3 g/L), and prealbumin level was 31 +/- 8 mg/dL. The survival rate was 78.7% after 2 years. Survival was influenced by age, presence of diabetes, use of high-flux membrane, and serum albumin level, but not other variables, including Kt/V and prealbumin level. Two-year variations in values for urea, creatinine, and weight were predictive of survival in univariate, but not multivariate, analyses.

CONCLUSION

In patients on dialysis therapy for a long period, better survival was observed when high-flux dialysis membranes were used.

Authors+Show Affiliations

Département de Néphrologie, Centre Hospitalier Universitaire and Université Bordeaux 2, Bordeaux, France. ph.chauveau@wanadoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

15754279

Citation

Chauveau, Philippe, et al. "Dialyzer Membrane Permeability and Survival in Hemodialysis Patients." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, vol. 45, no. 3, 2005, pp. 565-71.
Chauveau P, Nguyen H, Combe C, et al. Dialyzer membrane permeability and survival in hemodialysis patients. Am J Kidney Dis. 2005;45(3):565-71.
Chauveau, P., Nguyen, H., Combe, C., Chêne, G., Azar, R., Cano, N., Canaud, B., Fouque, D., Laville, M., Leverve, X., Roth, H., & Aparicio, M. (2005). Dialyzer membrane permeability and survival in hemodialysis patients. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 45(3), 565-71.
Chauveau P, et al. Dialyzer Membrane Permeability and Survival in Hemodialysis Patients. Am J Kidney Dis. 2005;45(3):565-71. PubMed PMID: 15754279.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dialyzer membrane permeability and survival in hemodialysis patients. AU - Chauveau,Philippe, AU - Nguyen,Hiep, AU - Combe,Christian, AU - Chêne,Geneviève, AU - Azar,Raymond, AU - Cano,Noël, AU - Canaud,Bernard, AU - Fouque,Denis, AU - Laville,Maurice, AU - Leverve,Xavier, AU - Roth,Hubert, AU - Aparicio,Michel, AU - ,, PY - 2005/3/9/pubmed PY - 2005/10/14/medline PY - 2005/3/9/entrez SP - 565 EP - 71 JF - American journal of kidney diseases : the official journal of the National Kidney Foundation JO - Am J Kidney Dis VL - 45 IS - 3 N2 - BACKGROUND: We previously showed that nutritional protein concentrations were predictive of outcome, whereas variables reflecting body composition and dialysis dose were not, in a 30-month prospective follow-up of 1,610 hemodialysis patients. Information on dialysis membrane and erythropoietin use had to be evaluated in an additional follow-up. METHODS: A subset of 650 patients from the initial cohort of 1,610 was analyzed for survival in a 2-year extension of follow-up. Detailed data were collected: demographics; cause of renal failure; time on dialysis therapy; type of membrane; erythropoietin treatment; body mass index (BMI); predialysis albumin, prealbumin, and bicarbonate levels; and outcome. Normalized protein catabolic rate (nPCR), dialysis adequacy, and lean body mass were computed from predialysis and postdialysis urea and creatinine values. RESULTS: Patient characteristics were age of 61 +/- 16 years, 58% men, BMI of 22.7 +/- 4.4 kg/m2 , time on dialysis therapy of 102 +/- 73 months, and 8.8% had diabetes. Dialysis parameters were duration of 247 +/- 31 minutes, Kt/V of 1.4 +/- 0.3, and nPCR of 1.2 +/- 0.3 g/kg/d. Albumin level was 3.73 +/- 0.53 g/dL (37.3 +/- 5.3 g/L), and prealbumin level was 31 +/- 8 mg/dL. The survival rate was 78.7% after 2 years. Survival was influenced by age, presence of diabetes, use of high-flux membrane, and serum albumin level, but not other variables, including Kt/V and prealbumin level. Two-year variations in values for urea, creatinine, and weight were predictive of survival in univariate, but not multivariate, analyses. CONCLUSION: In patients on dialysis therapy for a long period, better survival was observed when high-flux dialysis membranes were used. SN - 1523-6838 UR - https://www.unboundmedicine.com/medline/citation/15754279/Dialyzer_membrane_permeability_and_survival_in_hemodialysis_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0272638604015951 DB - PRIME DP - Unbound Medicine ER -