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Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10.
Neurobiol Dis. 2005 Apr; 18(3):618-27.ND

Abstract

Neuronal cells depend on mitochondrial oxidative phosphorylation for most of their energy needs and therefore are at a particular risk for oxidative stress. Mitochondria play an important role in energy production and oxidative stress-induced apoptosis. In the present study, we have demonstrated that external oxidative stress induces mitochondrial dysfunction leading to increased ROS generation and ultimately apoptotic cell death in neuronal cells. Furthermore, we have investigated the role of Coenzyme Q10 as a neuroprotective agent. Coenzyme Q10 is a component of the mitochondrial respiratory chain and a potent anti-oxidant. Our results indicate that total cellular ROS generation was inhibited by Coenzyme Q10. Further, pre-treatment with Coenzyme Q10 maintained mitochondrial membrane potential during oxidative stress and reduced the amount of mitochondrial ROS generation. Our study suggests that water-soluble Coenzyme Q10 acts by stabilizing the mitochondrial membrane when neuronal cells are subjected to oxidative stress. Therefore, Coenzyme Q10 has the potential to be used as a therapeutic intervention for neurodegenerative diseases.

Authors+Show Affiliations

Department of Biochemistry and Chemistry, 277-1 Essex Hall, University of Windsor, 401 Sunset Avenue, Windsor, ON, Canada N9B 3P4.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15755687

Citation

Somayajulu, M, et al. "Role of Mitochondria in Neuronal Cell Death Induced By Oxidative Stress; Neuroprotection By Coenzyme Q10." Neurobiology of Disease, vol. 18, no. 3, 2005, pp. 618-27.
Somayajulu M, McCarthy S, Hung M, et al. Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10. Neurobiol Dis. 2005;18(3):618-27.
Somayajulu, M., McCarthy, S., Hung, M., Sikorska, M., Borowy-Borowski, H., & Pandey, S. (2005). Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10. Neurobiology of Disease, 18(3), 618-27.
Somayajulu M, et al. Role of Mitochondria in Neuronal Cell Death Induced By Oxidative Stress; Neuroprotection By Coenzyme Q10. Neurobiol Dis. 2005;18(3):618-27. PubMed PMID: 15755687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10. AU - Somayajulu,M, AU - McCarthy,S, AU - Hung,M, AU - Sikorska,M, AU - Borowy-Borowski,H, AU - Pandey,S, PY - 2003/12/19/received PY - 2004/06/01/revised PY - 2004/10/26/accepted PY - 2005/3/10/pubmed PY - 2005/5/18/medline PY - 2005/3/10/entrez SP - 618 EP - 27 JF - Neurobiology of disease JO - Neurobiol. Dis. VL - 18 IS - 3 N2 - Neuronal cells depend on mitochondrial oxidative phosphorylation for most of their energy needs and therefore are at a particular risk for oxidative stress. Mitochondria play an important role in energy production and oxidative stress-induced apoptosis. In the present study, we have demonstrated that external oxidative stress induces mitochondrial dysfunction leading to increased ROS generation and ultimately apoptotic cell death in neuronal cells. Furthermore, we have investigated the role of Coenzyme Q10 as a neuroprotective agent. Coenzyme Q10 is a component of the mitochondrial respiratory chain and a potent anti-oxidant. Our results indicate that total cellular ROS generation was inhibited by Coenzyme Q10. Further, pre-treatment with Coenzyme Q10 maintained mitochondrial membrane potential during oxidative stress and reduced the amount of mitochondrial ROS generation. Our study suggests that water-soluble Coenzyme Q10 acts by stabilizing the mitochondrial membrane when neuronal cells are subjected to oxidative stress. Therefore, Coenzyme Q10 has the potential to be used as a therapeutic intervention for neurodegenerative diseases. SN - 0969-9961 UR - https://www.unboundmedicine.com/medline/citation/15755687/Role_of_mitochondria_in_neuronal_cell_death_induced_by_oxidative_stress L2 - https://linkinghub.elsevier.com/retrieve/pii/S0969-9961(04)00271-2 DB - PRIME DP - Unbound Medicine ER -