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Food intolerance in rheumatoid arthritis. I. A double blind, controlled trial of the clinical effects of elimination of milk allergens and azo dyes.
Ann Rheum Dis 1992; 51(3):298-302AR

Abstract

The hypothetically negative influence of food on the clinical activity of seropositive rheumatoid arthritis was studied using two types of artificial elementary food. One diet was allergen free, the other allergen restricted, containing only lactoproteins and yellow dyes. Ninety four patients entered the study, which lasted 12 weeks. During the second four week period they were randomly assigned to one of the two artificial foods. Comparison between baseline and subsequent periods showed only subjective improvements. No differences were seen between the clinical effects of the two tested diets. Nine patients (three in the allergen restricted group, six in the allergen free group) showed favourable responses, followed by marked disease exacerbation during rechallenge. Dietary manipulation also brought about changes in objective disease activity parameters in these patients. The existence of a subgroup of patients in whom food intolerance influences the activity of rheumatoid factor seropositive rheumatoid arthritis deserves serious consideration.

Authors+Show Affiliations

Department of Rheumatology, Jan van Breemen Instituut and Academisch, Medisch Centrum, University of Amsterdam, The Netherlands.No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1575571

Citation

van de Laar, M A., and J K. van der Korst. "Food Intolerance in Rheumatoid Arthritis. I. a Double Blind, Controlled Trial of the Clinical Effects of Elimination of Milk Allergens and Azo Dyes." Annals of the Rheumatic Diseases, vol. 51, no. 3, 1992, pp. 298-302.
van de Laar MA, van der Korst JK. Food intolerance in rheumatoid arthritis. I. A double blind, controlled trial of the clinical effects of elimination of milk allergens and azo dyes. Ann Rheum Dis. 1992;51(3):298-302.
van de Laar, M. A., & van der Korst, J. K. (1992). Food intolerance in rheumatoid arthritis. I. A double blind, controlled trial of the clinical effects of elimination of milk allergens and azo dyes. Annals of the Rheumatic Diseases, 51(3), pp. 298-302.
van de Laar MA, van der Korst JK. Food Intolerance in Rheumatoid Arthritis. I. a Double Blind, Controlled Trial of the Clinical Effects of Elimination of Milk Allergens and Azo Dyes. Ann Rheum Dis. 1992;51(3):298-302. PubMed PMID: 1575571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Food intolerance in rheumatoid arthritis. I. A double blind, controlled trial of the clinical effects of elimination of milk allergens and azo dyes. AU - van de Laar,M A, AU - van der Korst,J K, PY - 1992/3/1/pubmed PY - 1992/3/1/medline PY - 1992/3/1/entrez SP - 298 EP - 302 JF - Annals of the rheumatic diseases JO - Ann. Rheum. Dis. VL - 51 IS - 3 N2 - The hypothetically negative influence of food on the clinical activity of seropositive rheumatoid arthritis was studied using two types of artificial elementary food. One diet was allergen free, the other allergen restricted, containing only lactoproteins and yellow dyes. Ninety four patients entered the study, which lasted 12 weeks. During the second four week period they were randomly assigned to one of the two artificial foods. Comparison between baseline and subsequent periods showed only subjective improvements. No differences were seen between the clinical effects of the two tested diets. Nine patients (three in the allergen restricted group, six in the allergen free group) showed favourable responses, followed by marked disease exacerbation during rechallenge. Dietary manipulation also brought about changes in objective disease activity parameters in these patients. The existence of a subgroup of patients in whom food intolerance influences the activity of rheumatoid factor seropositive rheumatoid arthritis deserves serious consideration. SN - 0003-4967 UR - https://www.unboundmedicine.com/medline/citation/1575571/full_citation L2 - http://ard.bmj.com/cgi/pmidlookup?view=long&pmid=1575571 DB - PRIME DP - Unbound Medicine ER -