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Food intolerance in rheumatoid arthritis. I. A double blind, controlled trial of the clinical effects of elimination of milk allergens and azo dyes.

Abstract

The hypothetically negative influence of food on the clinical activity of seropositive rheumatoid arthritis was studied using two types of artificial elementary food. One diet was allergen free, the other allergen restricted, containing only lactoproteins and yellow dyes. Ninety four patients entered the study, which lasted 12 weeks. During the second four week period they were randomly assigned to one of the two artificial foods. Comparison between baseline and subsequent periods showed only subjective improvements. No differences were seen between the clinical effects of the two tested diets. Nine patients (three in the allergen restricted group, six in the allergen free group) showed favourable responses, followed by marked disease exacerbation during rechallenge. Dietary manipulation also brought about changes in objective disease activity parameters in these patients. The existence of a subgroup of patients in whom food intolerance influences the activity of rheumatoid factor seropositive rheumatoid arthritis deserves serious consideration.

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  • Authors+Show Affiliations

    ,

    Department of Rheumatology, Jan van Breemen Instituut and Academisch, Medisch Centrum, University of Amsterdam, The Netherlands.

    Source

    Annals of the rheumatic diseases 51:3 1992 Mar pg 298-302

    MeSH

    Allergens
    Animals
    Arthritis, Rheumatoid
    Azo Compounds
    Double-Blind Method
    Female
    Food Hypersensitivity
    Food, Formulated
    Humans
    Male
    Middle Aged
    Milk
    Treatment Outcome

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    1575571

    Citation

    van de Laar, M A., and J K. van der Korst. "Food Intolerance in Rheumatoid Arthritis. I. a Double Blind, Controlled Trial of the Clinical Effects of Elimination of Milk Allergens and Azo Dyes." Annals of the Rheumatic Diseases, vol. 51, no. 3, 1992, pp. 298-302.
    van de Laar MA, van der Korst JK. Food intolerance in rheumatoid arthritis. I. A double blind, controlled trial of the clinical effects of elimination of milk allergens and azo dyes. Ann Rheum Dis. 1992;51(3):298-302.
    van de Laar, M. A., & van der Korst, J. K. (1992). Food intolerance in rheumatoid arthritis. I. A double blind, controlled trial of the clinical effects of elimination of milk allergens and azo dyes. Annals of the Rheumatic Diseases, 51(3), pp. 298-302.
    van de Laar MA, van der Korst JK. Food Intolerance in Rheumatoid Arthritis. I. a Double Blind, Controlled Trial of the Clinical Effects of Elimination of Milk Allergens and Azo Dyes. Ann Rheum Dis. 1992;51(3):298-302. PubMed PMID: 1575571.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Food intolerance in rheumatoid arthritis. I. A double blind, controlled trial of the clinical effects of elimination of milk allergens and azo dyes. AU - van de Laar,M A, AU - van der Korst,J K, PY - 1992/3/1/pubmed PY - 1992/3/1/medline PY - 1992/3/1/entrez SP - 298 EP - 302 JF - Annals of the rheumatic diseases JO - Ann. Rheum. Dis. VL - 51 IS - 3 N2 - The hypothetically negative influence of food on the clinical activity of seropositive rheumatoid arthritis was studied using two types of artificial elementary food. One diet was allergen free, the other allergen restricted, containing only lactoproteins and yellow dyes. Ninety four patients entered the study, which lasted 12 weeks. During the second four week period they were randomly assigned to one of the two artificial foods. Comparison between baseline and subsequent periods showed only subjective improvements. No differences were seen between the clinical effects of the two tested diets. Nine patients (three in the allergen restricted group, six in the allergen free group) showed favourable responses, followed by marked disease exacerbation during rechallenge. Dietary manipulation also brought about changes in objective disease activity parameters in these patients. The existence of a subgroup of patients in whom food intolerance influences the activity of rheumatoid factor seropositive rheumatoid arthritis deserves serious consideration. SN - 0003-4967 UR - https://www.unboundmedicine.com/medline/citation/1575571/full_citation L2 - http://ard.bmj.com/cgi/pmidlookup?view=long&pmid=1575571 DB - PRIME DP - Unbound Medicine ER -