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Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer.
Clin Cancer Res. 2005 Mar 01; 11(5):1743-50.CC

Abstract

PURPOSE

The expression of chemokine receptors CXCR4 and CCR7 has been associated with tumor dissemination and poor prognosis in a limited number of tumor entities. However, no data are currently available on the impact of chemokine receptor expression on disease progression and prognosis in human colorectal cancer.

EXPERIMENTAL DESIGN

The expression of CXCR4 and CCR7 was evaluated in 96 patients with histologically confirmed colorectal cancers and in four colorectal cancer cell lines by immunohistochemical staining. Furthermore, cell migration assays were done with SW480, SW620, and LS174T cancer cells to confirm the effect of the CXCR4 ligand stromal cell-derived factor 1alpha on migration.

RESULTS

Human colorectal cancer specimens and cell lines displayed a CXCR4 and CCR7 expression with variable intensities. Interestingly, strong expression of CXCR4, but not of CCR7, was significantly associated with higher Union International Contre Cancer stages 3/4 (P = 0.0017), lymph node metastasis (P = 0.00375), and distant metastasis (P = 0.00003) and further correlated with a reduced 3-year survival rate (P = 0.1). Strong CXCR4 and CCR7 expression positively correlated with the location of the primary tumor in the rectum (P < 0.01). Furthermore, activation of CXCR4-expressing cancer cells by stromal cell-derived factor 1alpha resulted in a significant increase of cell migration (P < 0.014).

CONCLUSION

Strong expression of CXCR4 by colorectal cancer cells is significantly associated with lymphatic and distant dissemination in patients with colorectal cancer as well as with cancer cell migration in vitro.

Authors+Show Affiliations

First Department of Internal Medicine and Institutes of Pathology and Surgery, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany. dr_schimanski@yahoo.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15755995

Citation

Schimanski, Carl C., et al. "Effect of Chemokine Receptors CXCR4 and CCR7 On the Metastatic Behavior of Human Colorectal Cancer." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, vol. 11, no. 5, 2005, pp. 1743-50.
Schimanski CC, Schwald S, Simiantonaki N, et al. Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer. Clin Cancer Res. 2005;11(5):1743-50.
Schimanski, C. C., Schwald, S., Simiantonaki, N., Jayasinghe, C., Gönner, U., Wilsberg, V., Junginger, T., Berger, M. R., Galle, P. R., & Moehler, M. (2005). Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 11(5), 1743-50.
Schimanski CC, et al. Effect of Chemokine Receptors CXCR4 and CCR7 On the Metastatic Behavior of Human Colorectal Cancer. Clin Cancer Res. 2005 Mar 1;11(5):1743-50. PubMed PMID: 15755995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer. AU - Schimanski,Carl C, AU - Schwald,Stefan, AU - Simiantonaki,Nektaria, AU - Jayasinghe,Caren, AU - Gönner,Ursula, AU - Wilsberg,Vanessa, AU - Junginger,Theodor, AU - Berger,Martin R, AU - Galle,Peter R, AU - Moehler,Markus, PY - 2005/3/10/pubmed PY - 2005/6/21/medline PY - 2005/3/10/entrez SP - 1743 EP - 50 JF - Clinical cancer research : an official journal of the American Association for Cancer Research JO - Clin Cancer Res VL - 11 IS - 5 N2 - PURPOSE: The expression of chemokine receptors CXCR4 and CCR7 has been associated with tumor dissemination and poor prognosis in a limited number of tumor entities. However, no data are currently available on the impact of chemokine receptor expression on disease progression and prognosis in human colorectal cancer. EXPERIMENTAL DESIGN: The expression of CXCR4 and CCR7 was evaluated in 96 patients with histologically confirmed colorectal cancers and in four colorectal cancer cell lines by immunohistochemical staining. Furthermore, cell migration assays were done with SW480, SW620, and LS174T cancer cells to confirm the effect of the CXCR4 ligand stromal cell-derived factor 1alpha on migration. RESULTS: Human colorectal cancer specimens and cell lines displayed a CXCR4 and CCR7 expression with variable intensities. Interestingly, strong expression of CXCR4, but not of CCR7, was significantly associated with higher Union International Contre Cancer stages 3/4 (P = 0.0017), lymph node metastasis (P = 0.00375), and distant metastasis (P = 0.00003) and further correlated with a reduced 3-year survival rate (P = 0.1). Strong CXCR4 and CCR7 expression positively correlated with the location of the primary tumor in the rectum (P < 0.01). Furthermore, activation of CXCR4-expressing cancer cells by stromal cell-derived factor 1alpha resulted in a significant increase of cell migration (P < 0.014). CONCLUSION: Strong expression of CXCR4 by colorectal cancer cells is significantly associated with lymphatic and distant dissemination in patients with colorectal cancer as well as with cancer cell migration in vitro. SN - 1078-0432 UR - https://www.unboundmedicine.com/medline/citation/15755995/Effect_of_chemokine_receptors_CXCR4_and_CCR7_on_the_metastatic_behavior_of_human_colorectal_cancer_ L2 - http://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=15755995 DB - PRIME DP - Unbound Medicine ER -