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A prospective study of serum insulin-like growth factor-I (IGF-I), IGF-II, IGF-binding protein-3 and breast cancer risk.
Br J Cancer 2005; 92(7):1283-7BJ

Abstract

The associations between serum concentrations of insulin-like growth factor-I (IGF-I), IGF-II and IGF-binding proteins (IGFBP)-3 and risk of breast cancer were investigated in a nested case-control study involving 117 cases (70 premenopausal and 47 postmenopausal at blood collection) and 350 matched controls within a cohort of women from the island of Guernsey, UK. Women using exogenous hormones at the time of blood collection were excluded. Premenopausal women in the top vs bottom third of serum IGF-I concentration had a nonsignificantly increased risk for breast cancer after adjustment for IGFBP-3 (odds ratio (OR) 1.71; 95% confidence interval (CI): 0.74-3.95; test for linear trend, P=0.21). Serum IGFBP-3 was associated with a reduction in risk in premenopausal women after adjustment for IGF-I (top third vs the bottom third: OR 0.49; 95% CI: 0.21-1.12, P for trend=0.07). Neither IGF-I nor IGFBP-3 was associated with risk in postmenopausal women and serum IGF-II concentration was not associated with risk in pre- or postmenopausal women. These data are compatible with the hypothesis that premenopausal women with a relatively high circulating concentration of IGF-I and low IGFBP-3 are at an increased risk of developing breast cancer.

Authors+Show Affiliations

Cancer Research UK Epidemiology Unit, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15756268

Citation

Allen, N E., et al. "A Prospective Study of Serum Insulin-like Growth factor-I (IGF-I), IGF-II, IGF-binding Protein-3 and Breast Cancer Risk." British Journal of Cancer, vol. 92, no. 7, 2005, pp. 1283-7.
Allen NE, Roddam AW, Allen DS, et al. A prospective study of serum insulin-like growth factor-I (IGF-I), IGF-II, IGF-binding protein-3 and breast cancer risk. Br J Cancer. 2005;92(7):1283-7.
Allen, N. E., Roddam, A. W., Allen, D. S., Fentiman, I. S., Dos Santos Silva, I., Peto, J., ... Key, T. J. (2005). A prospective study of serum insulin-like growth factor-I (IGF-I), IGF-II, IGF-binding protein-3 and breast cancer risk. British Journal of Cancer, 92(7), pp. 1283-7.
Allen NE, et al. A Prospective Study of Serum Insulin-like Growth factor-I (IGF-I), IGF-II, IGF-binding Protein-3 and Breast Cancer Risk. Br J Cancer. 2005 Apr 11;92(7):1283-7. PubMed PMID: 15756268.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of serum insulin-like growth factor-I (IGF-I), IGF-II, IGF-binding protein-3 and breast cancer risk. AU - Allen,N E, AU - Roddam,A W, AU - Allen,D S, AU - Fentiman,I S, AU - Dos Santos Silva,I, AU - Peto,J, AU - Holly,J M P, AU - Key,T J, PY - 2005/3/10/pubmed PY - 2005/5/27/medline PY - 2005/3/10/entrez SP - 1283 EP - 7 JF - British journal of cancer JO - Br. J. Cancer VL - 92 IS - 7 N2 - The associations between serum concentrations of insulin-like growth factor-I (IGF-I), IGF-II and IGF-binding proteins (IGFBP)-3 and risk of breast cancer were investigated in a nested case-control study involving 117 cases (70 premenopausal and 47 postmenopausal at blood collection) and 350 matched controls within a cohort of women from the island of Guernsey, UK. Women using exogenous hormones at the time of blood collection were excluded. Premenopausal women in the top vs bottom third of serum IGF-I concentration had a nonsignificantly increased risk for breast cancer after adjustment for IGFBP-3 (odds ratio (OR) 1.71; 95% confidence interval (CI): 0.74-3.95; test for linear trend, P=0.21). Serum IGFBP-3 was associated with a reduction in risk in premenopausal women after adjustment for IGF-I (top third vs the bottom third: OR 0.49; 95% CI: 0.21-1.12, P for trend=0.07). Neither IGF-I nor IGFBP-3 was associated with risk in postmenopausal women and serum IGF-II concentration was not associated with risk in pre- or postmenopausal women. These data are compatible with the hypothesis that premenopausal women with a relatively high circulating concentration of IGF-I and low IGFBP-3 are at an increased risk of developing breast cancer. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/15756268/A_prospective_study_of_serum_insulin_like_growth_factor_I__IGF_I__IGF_II_IGF_binding_protein_3_and_breast_cancer_risk_ L2 - http://dx.doi.org/10.1038/sj.bjc.6602471 DB - PRIME DP - Unbound Medicine ER -